IndraLab

Statements


OTUB1 deubiquitinates SMAD3. 3 / 3
1 | 2

reach
"OTUB1 could not directly de-ubiquitinate Smad2 and Smad3, while its effect is dependent on regulating ubiquitin E2 conjugating-enzyme activity."

"OTUB1 enhances TGFbeta signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3."

reach
"OTUB1 prevents SMAD3 ubiquitylation."