IndraLab

Statements


OTUB1 leads to the deubiquitination of TP53. 7 / 7
1 | 6

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"Otub1, a DUB from the OTU-domain containing protease family abrogates p53 ubiquitination and stabilizes and activates p53 in cells independent of its deubiquitinating enzyme activity [XREF_BIBR]."

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"OTUB1 blocks p53 ubiquitylation by MDM2 by interacting with and inhibiting UbcH5, and E2 conjugating enzyme for MDM2."

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"Examples for DUBs that might antagonize E4 dependent polyubiquitylation are USP47, a regulator of Base Excision Repair (BER) that controls DNA polymerase beta and OTUB1, which mediates DNA damage dependent deubiquitylation of p53 and MDM2 in the cytoplasm."

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"Interestingly, Otub1 abrogates p53 ubiquitination and stabilizes and activates p53 in cells independently of its deubiquitinating enzyme activity."

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"For example, USP7 regulates the stability of both p53 and Mdm2 and maintains p53 ubiquitination levels; 120 USP2 mediates the stability of Mdm2; 121 USP10 modulates p53 localization and stability; 122 OTUB1 abrogates p53 ubiquitination and activates p53."

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"For example, USP7 modulates the stability of both p53 and MDM2, and maintains the level of p53 ubiquitylation; USP2 affects the stability of MDM2; Otub1 inhibits p53 ubiquitination and activates p53 in cells; USP10 regulates the location and stability of p53, and stabilize both mutated and wild-type p53, thereby having a dual role in tumorigenesis."