IndraLab

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OTUB1 deubiquitinates FOXM1. 6 / 6
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"29 We have shown previously that OTUB1 can specifically limit FOXM1 polyubiquitination and its degradation, through its deubiquitinase enzymatic activity."
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"Conversely, the invitro deubiquitination assays revealed that both OTUB1 (WT) and OTUB1 (D88A), but not OTUB1 (C91A), could efficiently deubiquitinate FOXM1 (XREF_FIG C, invitro Deub, lanes 5-8), as expected."
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"Taken together, the results provided strong evidence that OTUB1 suppresses FOXM1 ubiquitination and degraduation."
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"OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer"
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"Moreover, OTUB1 can deubiquitinate and stabilize the forkhead transcription factor FOXM1, which promotes DNA damage response and genotoxic drug resistance in breast cancer."
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"OTUB1 mediates the deubiquitination of FOXM1 to promote renal cancer tumor progression (Zhou et al., 2020)."
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