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OTUB1 deubiquitinates FOXM1. 15 / 16
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"OTUB1 has been reported to block FOXM1 ubiquitination; thus, we further investigated this finding."
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"Other experiments confirmed that OTUB1 slowed FOXM1 degradation and reduced the FOXM1 ubiquitination level ( Figs."
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"Therefore, we believe that LINC00857 forms a protein scaffold that enhances the interaction between FOXM1 and OTUB1 and promotes the deubiquitination of FOXM1 by OTUB1."
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"The original cell lysates are shown in Fig. 6 C. Based on these results, we concluded that OTUB1 participates in the deubiquitination of the FOXM1 protein and, consequently, stabilizes the protein and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we showed that OTUB1 was involved in the deubiquitination and stabilization of the FOXM1 protein in one of the HCC cell lines, as in other cancer types [ 36 , 63 , 64 ]."
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"Taken together, the results provided strong evidence that OTUB1 suppresses FOXM1 ubiquitination and degraduation."
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"Moreover, OTUB1 can deubiquitinate and stabilize the forkhead transcription factor FOXM1, which promotes DNA damage response and genotoxic drug resistance in breast cancer."
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"29 We have shown previously that OTUB1 can specifically limit FOXM1 polyubiquitination and its degradation, through its deubiquitinase enzymatic activity."
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"They further showed OTUB1 decreases FOXM1 ubiquitination and promotes FOXM1 protein stability."
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"OTUB1 can also inhibit the ubiquitination of FOXM1, stabilize FOXM1 protein levels, downregulate FOXM1 protein levels in breast cancer, and increase the sensitivity of breast cancer cells to chemotherapeutic agents (57)."
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"Conversely, the invitro deubiquitination assays revealed that both OTUB1 (WT) and OTUB1 (D88A), but not OTUB1 (C91A), could efficiently deubiquitinate FOXM1 (XREF_FIG C, invitro Deub, lanes 5-8), as expected."
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"Although OTUB1 can promote the progression of ovarian cancer by catalyzing the deubiquitination of FoxM1 ( Wang et al., 2016; Karunarathna et al., 2016 ), the downstream molecular network regulated by[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A deubiquitination enzyme, OTUB1 inhibits FOXM1 ubiquitination and degradation, and silencing OTUB1 results in decreased FOXM1 expression, increased breast cancer proliferation and epirubicin resistan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Karunarathna et al. demonstrated that OTUB1 inhibits ubiquitination and degradation of FOXM1, promoting epirubicin resistance in breast cancer 30."
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"OTUB1 mediates the deubiquitination of FOXM1 to promote renal cancer tumor progression (Zhou et al., 2020)."
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