IndraLab

Statements

OTUB1 leads to the deubiquitination of MSH2. 6 / 7
1 | 6
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"Mechanistically, OTUB1 inhibits MSH2 ubiquitination by blocking ubiquitin transfer from E2 (Figure 5A)."
38264570
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"OTUB1 inhibits the ubiquitination of MSH2."
33640455
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"Collectively, these results suggest that MSH2 is a substrate of OTUB1 and that OTUB1 inhibits MSH2 ubiquitination."
33640455
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"These results strongly suggest that OTUB1 blocks MSH2 ubiquitination by inhibiting the E2 ligase activity, rather than by directly deubiquitinating MSH2."
33640455
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"We therefore conclude that OTUB1 prevents MSH2 ubiquitination by suppressing the E2 ligase activity."
33640455
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"It is possible that OTUB1 prevents MSH2 ubiquitination by inhibiting the E2 activity of HDAC6 or by competing with HDAC6 for the MSH2 residues located in the central domain."
33640455