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OTUB1 deubiquitinates BIRC2. 2 / 2
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"The results showed that OTUB1 deubiquitinates c-IAP1 and further facilitates c-IAP1-mediated polyubiquitination of PIPK1 to restrain necroptosis."
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"Here, we describe the identification of <span class="match term0">OTUB1</span> as a c-IAP-associated deubiquitinating enzyme that regulates <span class="match term1">C-IAP1</span> stability. <span class="match term0">OTUB1</span> disassembles K48-linked polyubiquitin chains from <span class="match term1">C-IAP1</span> in vitro and in vivo within the TWEAK receptor-signalling complex."
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