IndraLab

Statements


OTUB1 deubiquitinates SMAD2_3. 3 / 3
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"These results imply that OTUB1 inhibits the ubiquitylation of SMAD2/3 rather than directly deubiquitylating them."

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"Interestingly, it was found that the mechanism is non canonical and non catalytic : instead of OTUB1 directly deubiquitinating SMAD2/3 rather it interacts with the E2 ligases prevents the transfer of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"This led us to hypothesize that OTUB1 might inhibit the ubiquitylation of SMAD2/3."