IndraLab

Statements

OTUB1 leads to the deubiquitination of UBE2N. 4 / 4
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"Although <span class="match term0">OTUB1</span> is not catalytically involved in deubiquitinating these K63-linked chains, it may interact with <span class="match term1">Ubc13</span> and inhibit the E3 ligase RNF168"
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"They showed OTUB1 decreases UBC13 ubiquitination and increases its protein level."
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"Since, OTUB1 inhibits UBC13 dependent polyubiquitylation but not monoubiquitylation, it may be that a single ubiquitin conjugated to another protein at DSBs is sufficient to be recognized by the MIU d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 3e, OTUB1 reduced the K48-linked ubiquitination of UBC13 in TgPFN-stimulated BMDCs."
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