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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUB1 deubiquitinates SMAD2. 3 / 3

1 | 2

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ubibrowser

"OTUB1 enhances TGFbeta signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3."

24071738

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reach

"OTUB1 could not directly de-ubiquitinate Smad2 and Smad3, while its effect is dependent on regulating ubiquitin E2 conjugating-enzyme activity."

27604640

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reach

"Recently, OTUB1, a DUB, was reported to reduce poly-ubiquitination of Smad2 and Smad3 through inhibition of the E2 ubiquitin conjugating enzymes."

27604640

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...