IndraLab

Statements

OTUB1 leads to the deubiquitination of RAS. 6 / 6
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"OTUB1 inhibits RAS ubiquitination independently of its catalytic activity resulting in sequestration of RAS on the plasma membrane."
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"In fact, invitro ubiquitination of RAS was abolished by wt OTUB1, but not by deltaN (1-30) OTUB1-mutant lacking binding to E2 (Fig XREF_FIG A)."
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"Consistent with the observation that OTUB1 inhibits RAS ubiquitination, analysis of RAS localization revealed that OTUB1 overexpression augmented the presence of RAS proteins on the plasma membrane (Fig XREF_FIG E and F; XREF_SUPPLEMENTARY)."
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"OTUB1 triggers activation of the MAPK pathway by inhibiting RAS ubiquitination."
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"Therefore, we tested whether the catalytic activity of OTUB1 is essential to promote RAS de-ubiquitination."
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"OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination."
26881969