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OTUB1 leads to the deubiquitination of RAS. 9 / 9
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"In addition, OTUB1 can inhibit the monoubiquitylation of RAS, promote lung cancer progression (58), stabilize Snail protein levels, and promote the metastasis of esophageal squamous carcinoma (59)."
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"OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination."
26881969
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"OTUB1 inhibits RAS ubiquitination independently of its catalytic activity resulting in sequestration of RAS on the plasma membrane."
26881969
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"Therefore, we tested whether the catalytic activity of OTUB1 is essential to promote RAS de-ubiquitination."
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"In fact, invitro ubiquitination of RAS was abolished by wt OTUB1, but not by deltaN (1-30) OTUB1-mutant lacking binding to E2 (Fig XREF_FIG A)."
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"Specifically, OTUB1 prevents ER-associated degradation of PD-L1 to contribute to immune suppression [6], inhibits Ras mono-ubiquitination to trigger lung cancer development [7], promotes RohA activation to induce prostate cancer metastasis [8], stabilizes ATF6 to facilitate bladder cancer growth [9], deubiquitinates and stabilizes FOXM1 to promote renal cell carcinoma progression [10], interacts with and stabilizes SLC7A11 to regulate ferroptosis [11], and stabilizes c-Myc to facilitate Myc-dependent multiple myeloma proliferation [12]."
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"On the other hand, the deubiquitinase OTUB1 inhibits the reversible ubiquitination of all RAS isoforms and promotes their localization to the plasma membrane, causing subsequent activation of MAPK signaling (Baietti et al, 2016)."
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"Consistent with the observation that OTUB1 inhibits RAS ubiquitination, analysis of RAS localization revealed that OTUB1 overexpression augmented the presence of RAS proteins on the plasma membrane (Fig XREF_FIG E and F; XREF_SUPPLEMENTARY)."
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"OTUB1 triggers activation of the MAPK pathway by inhibiting RAS ubiquitination."
26881969