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TNIP2 binds USP35. 7 / 8

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"USP35 acts as a functional DUB and interacts with ABIN-2."

26348204

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"Further, to examine if endogenous USP35 could bind to endogenous ABIN-2, lysates of LNCaP cells were immunoprecipitated with anti-ABIN-2 antibody and probed for USP35 by anti-USP35 antibody."

26348204

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"Further, to examine if endogenous USP35 could bind to endogenous ABIN-2, lysates of LNCaP cells were immunoprecipitated with anti-ABIN-2 antibody and probed for USP35 by anti-USP35 antibody."

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"In addition, endogenous USP35 binding to ABIN-2 was also observed in HeLa cells (Figure xref )."

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"To validate the interaction between USP35 and ABIN-2, HEK293T cells were transiently transfected with Myc-tagged USP35 alone or in combination with Flag-tagged ABIN-2."

26348204

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"To validate the interaction between USP35 and ABIN-2, HEK293T cells were transiently transfected with Myc tagged USP35 alone or in combination with Flag tagged ABIN-2."

26348204

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"In addition, endogenous USP35 binding to ABIN-2 was also observed in HeLa cells."

26348204

USP35 deubiquitinates TNIP2.

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USP35 deubiquitinates TNIP2. 5 / 5

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"These data illustrated that USP35 could promote ABIN-2 deubiquitination and decrease its proteasomal degradation."

26348204

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"USP35 deubiquitinates and stabilizes ABIN-2 protein."

26348204

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"Collectively, our data indicated that miR let-7a-regulated USP35 can inhibit NF-kappaB activation by deubiquitination and stabilization of ABIN-2 protein and eventually inhibit cell proliferation."

26348204

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"Together, these data illustrated that USP35 could up-regulate the expression of ABIN-2 by promoting ABIN-2 deubiquitination and decreasing its proteasomal degradation."

26348204

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"Subsequently, we presented a serial evidence to show that USP35 could deubiquitinate and stabilize ABIN-2 in cancer cells."

26348204

Modified USP35 leads to the deubiquitination of TNIP2. 1 / 1

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"Immunoprecipitation with Flag-ABIN-2 followed by HA-Ub immunoblotting showed overexpression of USP35 dramatically decreased the ABIN-2 ubiquitination."

26348204

USP35 activates TNIP2.

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"The results showed that overexpression of USP35 significantly extended the half-life of ABIN-2, while silenced expression of USP35 shortened the half-life of ABIN-2, indicating that USP35 promotes ABIN-2 protein stabilization."

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"Furthermore, USP35 can increase the activity of ABIN-2 by stabilizing its protein."

26348204

USP35 increases the amount of TNIP2.

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Modified USP35 increases the amount of TNIP2. 1 / 1

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"The following Western blot analysis showed that USP35 overexpression increased ABIN-2 expression while USP35 knockdown decreased its expression."

26348204

USP35 increases the amount of TNIP2. 1 / 1

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"Together, these data illustrated that USP35 could up-regulate the expression of ABIN-2 by promoting ABIN-2 deubiquitination and decreasing its proteasomal degradation."

26348204

USP35 ubiquitinates TNIP2.

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USP35 leads to the ubiquitination of TNIP2. 1 / 1

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"When activated by miR let-7a, USP35 inhibits NF-kappaB activation by deubiquitinating and stabilizing ABIN-2, which subsequently inhibits tumor growth 14."

29449677

USP35 decreases the amount of TNIP2.

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USP35 decreases the amount of TNIP2. 1 / 1

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"Meanwhile, proteasome inhibition caused a significant increase in ABIN-2 protein level and blocked the USP35 induced different expression of ABIN-2."

26348204

USP35 affects cell population proliferation

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USP35 inhibits cell population proliferation.

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USP35 inhibits cell population proliferation. 10 / 15

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"USP35 inhibits cancer cell proliferation."

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"Ectopic USP35 expression in cancer cells inhibited cell proliferation, while silencing USP35 induced proliferation in vitro."

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"USP35 overexpression inhibited cell proliferation in vitro and inhibited xenograft tumor growth in vivo."

26348204

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"USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaB activation through stabilization of ABIN-2."

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"Liu and colleagues have reported that USP35 inhibits cell proliferation via suppression of NF-kappaB activation by deubiquitination and stabilization of ABIN-2 (Liu C et al (2015) Oncotarget 6, 27891-27906)."

29764563

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"Liu and colleagues have reported that USP35 inhibits cell proliferation via suppression of NF-κB activation by deubiquitination and stabilization of ABIN-2 (Liu C et al (2015) Oncotarget 6, 27891–27906)."

29764563

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"Taking together, these results suggested that USP35 is an inhibitor of proliferation in cancer cells both in vitro and in vivo."

26348204

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"We then determined the roles of USP35 and found that overexpression of USP35 could inhibit cancer cell proliferation in vitro and tumorigenesis in vivo."

26348204

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"USP35 inhibits cancer cell proliferation."

26348204

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"MTT results showed that overexpression of USP35 inhibited cell proliferation significantly compared with their respective controls in both H1299 and LNCaP cells (Figure xref )."

26348204

USP35 activates cell population proliferation.

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USP35 activates cell population proliferation. 4 / 4

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"Ectopic USP35 expression in cancer cells inhibited cell proliferation, while silencing USP35 induced proliferation in vitro."

26348204

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"Further functional studies showed that enhanced USP35 expression promoted CRC cell proliferation and resistance to oxaliplatin (OXA) and 5-fluorouracil (5-FU), whereas USP35 depletion impeded cell proliferation and sensitized cells to OXA and 5-FU treatments."

36864055

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"Importantly, we demonstrated that FUCA1 was an essential mediator for USP35-induced cell proliferation and chemo-resistance in vitro and in vivo."

36864055

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"USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer."

36864055

USP35 is modified

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USP35 is phosphorylated.

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USP35 is phosphorylated. 5 / 5

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"The result showed that USP35 WT was robustly phosphorylated, whereas USP35 S613A phosphorylation was lost in the presence of activated AKT (Fig. xref )."

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"Similarly, USP35 S613A phosphorylation was reduced compared with USP35 WT in MCF-7 cells."

34131114

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"In addition, AKT, a key effector of PI3K, phosphorylated USP35 at Serine613, which promoted USP35 nuclear translocation, ERα transcriptional activity, and the growth of ER+ breast cancer cells."

34131114

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"Using antibodies recognizing the phosphorylated AKT consensus peptides, we found that there was robust phosphorylation of USP35 WT , whereas phosphorylation of USP35 S613A was greatly diminished in T-47D cells (Fig. xref )."

34131114

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"Importantly, AKT inhibitor MK2206 inhibited USP35 WT phosphorylation in MCF-7 cells (Fig. xref )."

34131114

USP35 is phosphorylated on S613. 4 / 4

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No evidence text available

18669648

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"These data indicate that AKT interacts with USP35 and phosphorylates USP35 at Ser613."

34131114

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"AKT promotes nuclear translocation of USP35 and enhances ERα transcriptional activity by phosphorylating USP35 at Ser613."

34131114

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No evidence text available

18669648

USP35 is ubiquitinated.

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USP35 is ubiquitinated. 3 / 3

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"However, CDH1 had no effect on the levels of USP35 protein and could not induce the ubiquitination of USP35 (Fig. xref )."

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"Compared to vector control, USP35 WT decreased ubiquitination of ERα (Fig. xref ), whereas USP35 C450A did not affect ubiquitination of ERα."

34131114

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"In addition, result from HA-ubiquitin immunoprecipitation followed by immunoblotting with the anti-ERα antibodies also showed that USP35 WT significantly reduced ubiquitination of ERα (Fig. xref )."

34131114

USP35 is degraded.

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USP35 is degraded. 1 / 1

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"The results showed that miR let-7a mimics increased USP35 expression and its inhibitor decreased USP35 expression."

26348204

TNIP2 affects USP35

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TNIP2 binds USP35. 7 / 8

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"USP35 acts as a functional DUB and interacts with ABIN-2."

26348204

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"Further, to examine if endogenous USP35 could bind to endogenous ABIN-2, lysates of LNCaP cells were immunoprecipitated with anti-ABIN-2 antibody and probed for USP35 by anti-USP35 antibody."

26348204

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"Further, to examine if endogenous USP35 could bind to endogenous ABIN-2, lysates of LNCaP cells were immunoprecipitated with anti-ABIN-2 antibody and probed for USP35 by anti-USP35 antibody."

26348204

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"In addition, endogenous USP35 binding to ABIN-2 was also observed in HeLa cells (Figure xref )."

26348204

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"To validate the interaction between USP35 and ABIN-2, HEK293T cells were transiently transfected with Myc-tagged USP35 alone or in combination with Flag-tagged ABIN-2."

26348204

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"To validate the interaction between USP35 and ABIN-2, HEK293T cells were transiently transfected with Myc tagged USP35 alone or in combination with Flag tagged ABIN-2."

26348204

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"In addition, endogenous USP35 binding to ABIN-2 was also observed in HeLa cells."

26348204

USP35 affects ESR1

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USP35 binds ESR1.

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USP35 binds ESR1. 3 / 3

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"In fact, in this dataset USP35 is significantly upregulated in ER+ tumors (FC =4.2, p <10 −5 ), perhaps providing evidence that conflict with the observation that USP35 amplification is associated with ER- tumors."

27029813

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"Using different deletion mutant of USP35, we found that USP35 interacts with ERα via its USP35 domain (data not shown)."

34131114

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"Results from immunoprecipitation experiment in MCF-7 cells revealed that USP35 and ERα can be reciprocally coimmunoprecipitated (Figs. xref f, xref ), indicating that USP35 interacted with endogenous ERα."

34131114

USP35 ubiquitinates ESR1.

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USP35 ubiquitinates ESR1. 2 / 2

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"Compared to vector control, USP35 WT decreased ubiquitination of ERα (Fig. xref ), whereas USP35 C450A did not affect ubiquitination of ERα."

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USP35 deubiquitinates ESR1.

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USP35 leads to the deubiquitination of ESR1. 1 / 1

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"Mechanistically, USP35 enhanced ERalpha stability by interacting and deubiquitinating ERalpha, and transcriptional activity of ERalpha by interacting with ERalpha in DNA regions containing estrogen response element."

34131114

USP35 activates ESR1.

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USP35 activates ESR1. 1 / 1

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"USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor alpha."

34131114

USP35 affects CDH1

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USP35 binds CDH1.

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CDH1 binds USP35. 6 / 6

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"Interestingly, USP35 transcript levels were found to be controlled by the FoxM1 transcription factor, and interestingly Cdh1 also interacts with USP35 even though it was shown to not affect its stability."

32201366

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"USP35 can bind to CDH1 and restore Aurora B levels that have been reduced by CDH1-induced ubiquitination, suggesting that USP35 counteracts the APC CDH1 -mediated ubiquitination of Aurora B. This possibility supports the occurrence of mitotic defects in USP35-depleted cells, as dysregulated levels of Aurora B protein may interfere with the progression of mitosis."

29449677

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"Interestingly, we also observed that USP35 could bind to CDH1 (Fig. xref )."

29449677

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"USP35 can bind to CDH1 and restore Aurora B levels that have been reduced by CDH1 induced ubiquitination, suggesting that USP35 counteracts the APC CDH1 -mediated ubiquitination of Aurora B."

29449677

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"Interestingly, we also observed that USP35 could bind to CDH1."

29449677

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"We surmise that Aurora B forms a complex with USP35 and CDH1 during mitosis, whereas USP35 mostly maintains Aurora B levels because the CDK1-dependent ubiquitination of CDH1 inhibits interaction with APC/C in the early phase."

29449677

USP35 inhibits CDH1.

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USP35 inhibits CDH1. 1 / 1

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"USP35 inhibits CDH1 mediated degradation of Aurora B. Having noted the effect of USP35 depletion on the levels of Aurora B protein, we expected that USP35 could deubiquitinate Aurora B, and counteract the ubiquitination activity of APC CDH1 E3 ligase."

29449677

CDH1 affects USP35

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CDH1 binds USP35.

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CDH1 binds USP35. 6 / 6

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32201366

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29449677

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"Interestingly, we also observed that USP35 could bind to CDH1 (Fig. xref )."

29449677

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"USP35 can bind to CDH1 and restore Aurora B levels that have been reduced by CDH1 induced ubiquitination, suggesting that USP35 counteracts the APC CDH1 -mediated ubiquitination of Aurora B."

29449677

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"Interestingly, we also observed that USP35 could bind to CDH1."

29449677

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29449677

CDH1 ubiquitinates USP35.

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CDH1 leads to the ubiquitination of USP35. 1 / 1

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"However, CDH1 had no effect on the levels of USP35 protein and could not induce the ubiquitination of USP35."

29449677

USP35 affects NFkappaB

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USP35 inhibits NFkappaB. 4 / 6

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"USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaB activation through stabilization of ABIN-2."

26348204

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"Functionally, both ABIN-2 and USP35 could inhibit TNFα-induced NF-κB activation and overexpression of ABIN-2 alleviated USP35-loss induced activation of NF-κB. Collectively, our data indicated that miR let-7a-regulated USP35 can inhibit NF-κB activation by deubiquitination and stabilization of ABIN-2 protein and eventually inhibit cell proliferation."

26348204

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"XREF_BIBR In addition, miR-let-7a was shown to regulate USP35 expression, which then inhibited NF-kappaB activation by deubiquitination and stabilization of TNIP2 protein."

32606763

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"Collectively, our data indicated that miR let-7a-regulated USP35 can inhibit NF-kappaB activation by deubiquitination and stabilization of ABIN-2 protein and eventually inhibit cell proliferation."

26348204

MARCHF8 affects USP35

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MARCHF8 activates USP35.

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MARCHF8 activates USP35. 4 / 4

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"In the present study, we first identified USP35, a member of the USP superfamily, can be up-regulated by the miR let-7a."

26348204

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"USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaB activation through stabilization of ABIN-2."

26348204

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"These findings indicate that USP35 up-regulated by miR let-7a potentially functions as a tumor suppressor and inhibits tumor growth."

26348204

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"The molecular pathways by which miR let-7a up-regulates USP35 need to be further investigated."

26348204

MARCHF8 increases the amount of USP35.

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MARCHF8 increases the amount of USP35. 2 / 2

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"Although, USP35 is not a predicted target of miR let-7a by the web based bioinformatic analysis, the fact from our experiment is that the expression of USP35 can be up-regulated by miR let-7a."

26348204

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"MiR let-7a up-regulates the expression of USP35."

26348204

AKT affects USP35

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AKT phosphorylates USP35.

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AKT phosphorylates USP35 on S613. 3 / 3

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"Collectively, our data indicate that USP35-S613 phosphorylation by AKT is required, but not sufficient, for USP35 enhancement of ERα target gene expression."

34131114

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"In addition, Akt phosphorylating Ser613 in USP35 is critical for USP35 nuclear translocation and enhancing ERα transcriptional activity (Fig. xref )."

34131114

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"Furthermore, phosphorylation of Ser613 in USP35 by AKT, an effector of PI3K, is critical for USP35 nuclear translocation and promoting ERα transcriptional activity and the growth of ER+ breast cancer cells."

34131114

AKT phosphorylates USP35. 2 / 2

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"In addition, AKT, a key effector of PI3K, phosphorylated USP35 at Serine613, which promoted USP35 nuclear translocation, ERalpha transcriptional activity, and the growth of ER+ breast cancer cells."

34131114

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"AKT phosphorylation of USP35 is critical for USP35′s action in ER+ breast cancer cells."

34131114

AKT binds USP35.

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AKT binds USP35. 1 / 1

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"These data indicate that AKT interacts with USP35 and phosphorylates USP35 at Ser613."

34131114

USP35 affects SLC40A1

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SLC40A1 binds USP35. 5 / 5

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"USP35 directly interacts with ferroportin and maintain its protein stability to prevent iron overload and ferroptosis."

33931967

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"Together, these data indicate that USP35 can directly interact with FPN and functions as a deubiquitinase to maintain its protein stability."

33931967

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"First, the specific domain through which USP35 interacts with FPN remains unclear and demands further investigation."

33931967

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"FPN ubiquitination is required for its internalization and degradation, and Zhang et al identified the deubiquitinated role of USP35 in ovarian cancer cells. xref , xref Consistently, we found that USP35 directly interacted with FPN and functioned as a deubiquitinase to maintain its protein stability."

33931967

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"Further studies determined that USP35 directly interacted with ferroportin (FPN) and functioned as a deubiquitinase to maintain its protein stability."

33931967

USP35 affects activation

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USP35 inhibits activation. 4 / 4

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"Taken together, these results suggest that USP35 could inhibit TNFα-induced NF-κB activation by stabilizing ABIN-2 protein."

26348204

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"USP35 inhibits TNFα-induced NF-κB activation through stabilizing ABIN-2 protein."

26348204

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"When activated by miR let-7a, USP35 inhibits NF-κB activation by deubiquitinating and stabilizing ABIN-2, which subsequently inhibits tumor growth xref ."

29449677

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"In addition, overexpression of USP35 inhibited TNFα-induced NF-κB activation by deubiquitination and stabilization of TNFAIP3 interacting protein 2 (ABIN-2)."

26348204

USP35 affects USP35

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USP35 decreases the amount of USP35. 1 / 3

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"The USP35 level was decreased by USP35 siRNA while toxicity by siRNA transfection in the cells was not observed."

29449677

Modified USP35 decreases the amount of USP35. 1 / 1

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"The results showed that miR let-7a mimics increased USP35 expression and its inhibitor decreased USP35 expression."

26348204

USP35 affects STING1

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USP35 inhibits STING1.

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USP35 inhibits STING1. 2 / 2

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"Our data further showed that USP35 can directly deubiquitinate and inactivate STING."

32678307

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"As mentioned above, USP35 can directly deubiquitinate STING with K6/K11/K27/K29/K63-linked polyubiquitin chains and inhibit STING."

35603197

USP35 deubiquitinates STING1.

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USP35 deubiquitinates STING1. 1 / 1

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"Our data further showed that USP35 can directly deubiquitinate and inactivate STING."

32678307

USP35 binds STING1.

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USP35 binds STING1. 1 / 1

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biogrid

No evidence text available

27801882

USP35 affects PRKN

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USP35 inhibits PRKN.

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USP35 inhibits PRKN. 2 / 3

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"Parkin mediated effects are further regulated by de-ubiquitinating enzymes, such as USP30 and USP35, which reportedly de-ubiquitinate Parkin substrates to antagonize mitophagy [24 *] or Parkin depende[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

26896558

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"Parkin mediated effects are further regulated by de-ubiquitinating enzymes, such as USP30 and USP35, which reportedly de-ubiquitinate Parkin substrates to antagonize mitophagy [XREF_BIBR] or Parkin dependent cell death [XREF_BIBR]."

26896558

USP35 deubiquitinates PRKN.

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USP35 deubiquitinates PRKN. 1 / 1

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"Reciprocally, the dequbiquitination enzymes USP30 and USP35 have been shown to antagonize the mitophagy process by deubiquitinating Parkin [138,139]."

30544615

USP35 affects cell death

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USP35 inhibits cell death.

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USP35 inhibits cell death. 2 / 2

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26896558

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"The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma."

37173391

USP35 activates cell death.

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USP35 activates cell death. 1 / 1

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"Taken together, USP35 plays a vital role in resistance to cisplatin-induced cell death through the overexpression of BIRC3."

35022505

USP35 affects Histone_H3

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USP35 phosphorylates Histone_H3.

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USP35 phosphorylates Histone_H3. 1 / 1

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"USP35 increases the phosphorylation of histone H3, indicating that USP35 is involved in the downstream signaling of Aurora B. In conclusion, USP35 is a DUB essential for the faithful progression of mitosis by maintaining the stability and function of Aurora B [ xref ]."

31795161

USP35 increases the amount of Histone_H3.

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USP35 increases the amount of Histone_H3. 1 / 1

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"However, phospho-histone H3 levels were decreased by USP35 knockdown regardless of whether MG132 was present or not."

29449677

USP35 decreases the amount of Histone_H3.

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USP35 decreases the amount of Histone_H3. 1 / 1

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"Western blot analysis also showed that the depletion of USP35 lowered the levels of both phospho-histone H3 and Aurora B protein in nocodazole treated cells."

29449677

USP35 affects Flag

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USP35 binds Flag. 3 / 3

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"Consistent with this, ectopically expressed Flag-USP35 was associated with endogenous Aurora B in HEK293T and HeLa cells, and conversely, endogenous USP35 was precipitated efficiently by HA-Aurora B affinity purification (Supplementary Fig. xref , xref , c)."

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"To test whether Ser613 can be phosphorylated by AKT, Flag-USP35 WT or Flag-USP35 S613A vector was cotransfected with the activated AKT mutant plasmid into 293 T cells."

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"To explore the effects of Ser613 phosphorylation on USP35 localization and function, MCF-7 and T-47D cells were engineered to express vector alone, Flag-USP35 WT , Flag-USP35 S613A , and Flag-USP35 S613E (Fig. xref )."

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ESR1 affects USP35

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USP35 binds ESR1. 3 / 3

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"Using different deletion mutant of USP35, we found that USP35 interacts with ERα via its USP35 domain (data not shown)."

34131114

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USP35 affects growth

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USP35 inhibits growth. 2 / 2

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"These results suggest that USP35 can inhibit cancer cell growth efficiently."

26348204

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"So we speculate that USP35 can inhibit cancer cell growth through inhibiting NF-κB pathway by stabilizing ABIN-2."

26348204

USP35 affects cell

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USP35 activates cell. 2 / 2

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"Further functional studies showed that enhanced USP35 expression promoted CRC cell proliferation and resistance to oxaliplatin ( OXA ) and 5-fluorouracil ( 5-FU ) , whereas USP35 depletion impeded cell proliferation and sensitized cells to OXA and 5-FU treatments ."

36864055

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"USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer ."

36864055

USP35 affects cell growth

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USP35 inhibits cell growth. 2 / 2

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"So we speculate that USP35 can inhibit cancer cell growth through inhibiting NF-kappaB pathway by stabilizing ABIN-2."

26348204

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"These results suggest that USP35 can inhibit cancer cell growth efficiently."

26348204

USP35 affects apoptotic process

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USP35 activates apoptotic process. 2 / 2

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"USP35 iso2 led to ER stress, BAP31 cleavage and activation of caspase-8 and caspase-3, resulting in apoptosis [74] ."

31208841

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"USP35 iso2 led to ER stress, BAP31 cleavage and activation of caspase-8 and caspase-3, resulting in apoptosis [XREF_BIBR]."

31208841

USP35 affects NPPA

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USP35 binds NPPA. 2 / 2

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"The production lots presented in Table xref were also analysed for the presence of the bacterial lipopolysaccharide (LPS), which is a membrane component of Gram‐negative bacteria that could act as endotoxin, according to the US Pharmacopeia method based on the use of amoebocyte lysate from the horseshoe crab (USP35‐NF30, xref ) and all the samples analysed tested negative."

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"At present, CRG has been included in the United States Pharmacopeia 35-National Formulary 30S1 (USP35-NF30S1), the British Pharmacopoeia 2012 (BP2012), and the European Pharmacopoeia 7.0 (EP7.0), implying that CRG may have a promising future as a pharmaceutical excipient."

32397584

USP35 affects FUCA1

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USP35 binds FUCA1.

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USP35 binds FUCA1. 1 / 1

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"Finally, we observed that nucleotide excision repair (NER) components (e.g., XPC, XPA, ERCC1) were up-regulated by USP35-FUCA1 axis, indicating a potential mechanism for USP35-FUCA1-mediated platinum resistance in CRC."

36864055

USP35 activates FUCA1.

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USP35 activates FUCA1. 1 / 1

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"USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer."

36864055

USP35 affects CPC proteins

| 2

USP35 increases the amount of CPC proteins.

| 1

USP35 increases the amount of CPC proteins. 1 / 1

| 1

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reach

"Indeed, USP35 knockdown could not disrupt the levels of other CPC proteins, such as INCENP or Survivin, indicating that USP35 does not affect other CPC proteins and may only have an effect on Aurora B. Based on these data, we concluded that USP35 induced deubiquitination of Aurora B could affect its downstream signaling, which is required for faithful mitotic progression."

29449677

USP35 binds CPC proteins.

| 1

USP35 binds CPC proteins. 1 / 1

| 1

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reach

"These results showed that USP35 interacts with Aurora B. Next, we examined whether USP35 interacts with other CPC proteins."

29449677

USP35 affects BIRC3

| 2

USP35 inhibits BIRC3.

| 1

USP35 inhibits BIRC3. 1 / 1

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reach

"Overexpression of USP35 in H460 cells increased the abundance of BIRC3, while USP35 knockdown in Anip973 cells decreased BIRC3 abundance."

35022505

USP35 activates BIRC3.

| 1

USP35 activates BIRC3. 1 / 1

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reach

"Overexpression of USP35 in H460 cells increased the abundance of BIRC3, while USP35 knockdown in Anip973 cells decreased BIRC3 abundance."

35022505

STUB1 affects USP35

| 2

STUB1 ubiquitinates USP35.

| 1

STUB1 ubiquitinates USP35. 1 / 1

| 1

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reach

"CHIP bound to HSP90 interacts with and ubiquitinates USP35."

37004621

STUB1 binds USP35.

| 1

STUB1 binds USP35. 1 / 1

| 1

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reach

"CHIP bound to HSP90 interacts with and ubiquitinates USP35."

37004621

NPPA affects USP35

| 2

USP35 binds NPPA. 2 / 2

| 2

➶

sparser

32625902

➶

sparser

32397584

FOXM1 affects USP35

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FOXM1 increases the amount of USP35. 2 / 2

| 2

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reach

"In addition, the mRNA and protein levels of both USP35 and Aurora B were increased by FoxM1 in a dose dependent manner."

29449677

➶

reach

"Finally, the transcription factor FoxM1 promotes the expression of USP35, as well as that of Aurora B, during the cell cycle."

29449677

Valproic acid affects USP35

1 |

Valproic acid demethylates USP35. 1 / 1

1 |

➶

ctd

No evidence text available

29154799

Tris(1,3-dichloro-2-propyl)phosphate affects USP35

1 |

Tris(1,3-dichloro-2-propyl)phosphate increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

26179874

Sunitinib affects USP35

1 |

Sunitinib decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Quercetin affects USP35

1 |

Quercetin increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

21632981

Paracetamol affects USP35

1 |

Paracetamol decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

29067470

Methamphetamine affects USP35

1 |

Methamphetamine decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

29802913

Leflunomide affects USP35

1 |

Leflunomide decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

28988120

Jinfukang affects USP35

1 |

Jinfukang increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

27392435

Hsa-miR-127-3p affects USP35

1 |

Hsa-miR-127-3p decreases the amount of USP35. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24374217

Hsa-let-7a-5p affects USP35

1 |

Hsa-let-7a-5p decreases the amount of USP35. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

26348204

Hexabromocyclododecane affects USP35

1 |

Hexabromocyclododecane decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

29177809

Cyclosporin A affects USP35

1 |

Cyclosporin A increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

25562108

Copper(II) sulfate affects USP35

1 |

Copper(II) sulfate increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

19549813

Cisplatin affects USP35

1 |

Cisplatin increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

27392435

Bisphenol A affects USP35

1 |

Bisphenol A decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

25181051

Benzo[a]pyrene affects USP35

1 |

Benzo[a]pyrene increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

21632981

Azathioprine affects USP35

1 |

Azathioprine increases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

22623647

Aurora subfamily affects USP35

| 1

USP35 binds aurora subfamily. 1 / 1

| 1

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sparser

"Although USP35 did not modify this ubiquitination of Aurora B, it is unclear whether USP35 is associated with the regulation of Aurora B localization during mitosis."

29764563

Aluminium atom affects USP35

1 |

Aluminium atom decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

21298039

Abrine affects USP35

1 |

Abrine decreases the amount of USP35. 1 / 1

1 |

➶

ctd

No evidence text available

31054353

USP35

1 |

USP35 binds USP35. 1 / 1

1 |

➶

biogrid

No evidence text available

25915564

USP35 affects ubiquitination

| 1

USP35 inhibits ubiquitination. 1 / 1

| 1

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sparser

"USP35 regulates the Aurora B protein levels during mitosis without affecting the localization of Aurora B. In other words, USP35 inhibits APC/C-CDH1-induced ubiquitination of Aurora B by cleaving Lys11-linked polyubiquitin chains and prevents it from proteasomal degradation ( xref d)."

31795161

USP35 affects type I interferons

| 1

USP35 increases the amount of type I interferons. 1 / 1

| 1

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reach

"Mechanistically, we found that silencing USP35 reinforces the activation of STING-TBK1-IRF3 pathway and promotes the expression of type I interferons."

32678307

USP35 affects sensitivity cisplatin-induced apoptosis

| 1

USP35 inhibits sensitivity cisplatin-induced apoptosis. 1 / 1

| 1

➶

eidos

"Depletion of USP35 increased the sensitivity of NSCLC to cisplatin-induced apoptosis ."

35022505

USP35 affects sensitivity ER breast cancer cells endocrine therapies

| 1

USP35 inhibits sensitivity ER breast cancer cells endocrine therapies. 1 / 1

| 1

➶

eidos

"USP35 promoted the growth of ER + breast cancer in vitro and in vivo , and reduced the sensitivity of ER + breast cancer cells to endocrine therapies such as tamoxifen and fulvestrant ."

34131114

USP35 affects oxaliplatin

| 1

USP35 activates oxaliplatin. 1 / 1

| 1

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reach

36864055

USP35 affects miRNA-140-3p

| 1

USP35 activates miRNA-140-3p. 1 / 1

| 1

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reach

"Estrogen enhanced USP35 protein levels by downregulating USP35 targeting miRNA-140-3p and miRNA-26a-5p."

34131114

USP35 affects metabolic process

| 1

USP35 activates metabolic process. 1 / 1

| 1

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reach

"Therefore, USP35/BRPF1 aixs could promote expressions of mevalonate (MVA) metabolism signature in a SREBP2-dependent manner."

36357379

USP35 affects localization

| 1

USP35 inhibits localization. 1 / 1

| 1

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reach

"Since it is known that the ubiquitination of Aurora B regulates its stability or localization XREF_BIBR, XREF_BIBR, we then tested whether USP35 could perturb the protein levels or localization of Aurora B."

29449677

USP35 affects growth ER breast cancer

| 1

USP35 activates growth ER breast cancer. 1 / 1

| 1

➶

eidos

"USP35 promoted the growth of ER + breast cancer in vitro and in vivo , and reduced the sensitivity of ER + breast cancer cells to endocrine therapies such as tamoxifen and fulvestrant ."

34131114

USP35 affects endoplasmic-reticulum-stress-induced apoptosis

| 1

USP35 inhibits endoplasmic-reticulum-stress-induced apoptosis. 1 / 1

| 1

➶

eidos

"USP35 mitigates endoplasmic-reticulum-stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer ."

34618999

USP35 affects degradation

| 1

USP35 inhibits degradation. 1 / 1

| 1

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sparser

"USP35 inhibits CDH1-mediated degradation of Aurora B."

29449677

USP35 affects cytokinesis

| 1

USP35 activates cytokinesis. 1 / 1

| 1

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reach

"We wanted to delineate the molecular mechanism by which the depletion of USP35 increases the frequency of mitotic defects and cytokinesis failures."

29449677

USP35 affects cisplatin-induced cell apoptosis

| 1

USP35 activates cisplatin-induced cell apoptosis. 1 / 1

| 1

➶

eidos

"USP35 alleviated cisplatin-induced cell apoptosis by regulating BIRC3 levels in NSCLC cells ."

35022505

USP35 affects cisplatin-induced apoptosis

| 1

USP35 activates cisplatin-induced apoptosis. 1 / 1

| 1

➶

eidos

"Ubiquitin-specific protease 35 ( USP35 ) mediates cisplatin-induced apoptosis by stabilizing BIRC3 in non-small cell lung cancer ."

35022505

USP35 affects cisplatin

| 1

USP35 inhibits cisplatin. 1 / 1

| 1

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reach

"Silencing USP35 potentiates cisplatin effects in ovarian cancer cells (85)."

35603197

USP35 affects aurora subfamily

| 1

USP35 binds aurora subfamily. 1 / 1

| 1

➶

sparser

"Although USP35 did not modify this ubiquitination of Aurora B, it is unclear whether USP35 is associated with the regulation of Aurora B localization during mitosis."

29764563

USP35 affects VDAC1

1 |

USP35 deubiquitinates VDAC1. 1 / 1

1 |

➶

ubibrowser

"Review"

26445063

USP35 affects TNFRSF10B

| 1

USP35 activates TNFRSF10B. 1 / 1

| 1

➶

reach

"USP35 iso2 upregulated C/EBP homologous protein (CHOP) and DR5 in U2OSFIpIn and HeLa FIpIn cells [74] ."

31208841

USP35 affects STUB1

| 1

STUB1 binds USP35. 1 / 1

| 1

➶

reach

"CHIP bound to HSP90 interacts with and ubiquitinates USP35."

37004621

USP35 affects SREBF2

| 1

USP35 activates SREBF2. 1 / 1

| 1

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reach

"Therefore, USP35/BRPF1 aixs could promote expressions of mevalonate (MVA) metabolism signature in a SREBP2-dependent manner."

36357379

USP35 affects RRBP1

| 1

RRBP1 binds USP35. 1 / 1

| 1

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sparser

"Collectively, these findings indicate that USP35 plays a critical role in resisting ER-stress-induced cell death through deubiquitinating RRBP1, hence providing a rationale to target the USP35-RRBP1 axis as an alternative therapeutic option for NSCLC."

34618999

USP35 affects RP23-170A23.3

1 |

USP35 binds RP23-170A23.3. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP35 affects Neoplasms

| 1

USP35 activates Neoplasms. 1 / 1

| 1

➶

reach

"Through a systematic survey in the association of human ubiquitin-specific proteases with patient prognosis of renal clear cell carcinoma and subsequent phenotypic validation, we uncovered the tumor-promoting role of USP35."

37173391

USP35 affects NOTCH1

| 1

USP35 binds NOTCH1. 1 / 1

| 1

➶

reach

"These results showed that USP35 interacts with Aurora B. Next, we examined whether USP35 interacts with other CPC proteins."

29449677

USP35 affects InR

| 1

USP35 binds InR. 1 / 1

| 1

➶

sparser

"USP35 expression is down-regulated in human cancer tissues and positively associated with miR let-7a expression."

26348204

USP35 affects Histone

| 1

Modified USP35 leads to the phosphorylation of Histone. 1 / 1

| 1

➶

reach

"In addition, the loss of USP35 decreases the phosphorylation of histone H3-Ser10, an Aurora B substrate."

29449677

USP35 affects Endoplasmic Reticulum Stress

| 1

USP35 activates Endoplasmic Reticulum Stress. 1 / 1

| 1

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reach

"USP35 iso2 led to ER stress, BAP31 cleavage and activation of caspase-8 and caspase-3, resulting in apoptosis [74] ."

31208841

USP35 affects ERalpha stability

| 1

USP35 activates ERalpha stability. 1 / 1

| 1

➶

eidos

"Mechanistically , USP35 enhanced ERalpha stability by interacting and deubiquitinating ERalpha , and transcriptional activity of ERalpha by interacting with ERalpha in DNA regions containing estrogen response element ."

34131114

USP35 affects ER-stress-induced cell apoptosis

| 1

USP35 activates ER-stress-induced cell apoptosis. 1 / 1

| 1

➶

eidos

"Functionally , USP35 alleviated ER-stress-induced cell apoptosis by stabilizing RRBP1 in NSCLC cells ."

34618999

USP35 affects DDIT3

| 1

USP35 activates DDIT3. 1 / 1

| 1

➶

reach

"USP35 iso2 upregulated C/EBP homologous protein (CHOP) and DR5 in U2OSFIpIn and HeLa FIpIn cells [74] ."

31208841

USP35 affects Carcinoma

| 1

USP35 inhibits Carcinoma. 1 / 1

| 1

➶

reach

"The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma."

37173391

USP35 affects CPC

| 1

USP35 binds CPC and CPC. 1 / 1

| 1

➶

sparser

"These results showed that USP35 interacts with Aurora B. Next, we examined whether USP35 interacts with other CPC proteins."

29449677

USP35 affects CEBP

| 1

USP35 activates CEBP. 1 / 1

| 1

➶

reach

"USP35 iso2 upregulated C/EBP homologous protein (CHOP) and DR5 in U2OSFIpIn and HeLa FIpIn cells [74] ."

31208841

USP35 affects BRPF1

| 1

USP35 deubiquitinates BRPF1. 1 / 1

| 1

➶

reach

"Mechanistically, we found that USP35 could directly deubiquitinate and stabilize BRPF1 proteins."

36357379

USP35 affects BIRC5

| 1

USP35 leads to the deubiquitination of BIRC5. 1 / 1

| 1

➶

reach

"USP35 interacted with and promoted the deubiquitination of the survivin protein."

34438346

USP35 affects AURKB

1 |

USP35 deubiquitinates AURKB. 1 / 1

1 |

➶

ubibrowser

"Recently, we have found that USP35 acts as a deubiquitinating enzyme (DUB) for Aurora B and affects its stability during cell division, thus being involved in the regulation of mitosis."

29764563