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USP35 activates FUCA1. 4 / 4
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"In parallel with the in vitro data, USP35 overexpression weakened drug-induced cell apoptosis while knockdown of FUCA1 in USP35-overexpressed cells restored drug-induced cell apoptosis, suggesting that USP35 contributes to OXA/5-FU resistance through stabilizing FUCA1 in vivo (Fig. 6D and S13A–C)."
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"We found that overexpression of wild-type USP35 (USP35 WT), not the catalytically inactive mutant USP35 (USP35 C450A), prevented FUCA1 from degradation in LoVo cells, whereas knockdown of USP35 accelerated FUCA1 degradation in DLD-1 cells (Fig. 4C, D)."
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"Resultantly, enhanced USP35 expression increased FUCA1 at protein levels in CRC cells and HEK293T in a dose dependent manner (Fig. S6A, B), while dampened USP35 expression clearly decreased the protein levels of FUCA1 in DLD-1 and HCT116 cells (Fig. S6C)."
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"USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer."
36864055