IndraLab

Statements

CDH1 binds USP35. 6 / 6
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sparser
"Interestingly, USP35 transcript levels were found to be controlled by the FoxM1 transcription factor, and interestingly Cdh1 also interacts with USP35 even though it was shown to not affect its stability."
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sparser
"USP35 can bind to CDH1 and restore Aurora B levels that have been reduced by CDH1-induced ubiquitination, suggesting that USP35 counteracts the APC CDH1 -mediated ubiquitination of Aurora B. This possibility supports the occurrence of mitotic defects in USP35-depleted cells, as dysregulated levels of Aurora B protein may interfere with the progression of mitosis."
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sparser
"Interestingly, we also observed that USP35 could bind to CDH1 (Fig.  xref )."
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reach
"USP35 can bind to CDH1 and restore Aurora B levels that have been reduced by CDH1 induced ubiquitination, suggesting that USP35 counteracts the APC CDH1 -mediated ubiquitination of Aurora B."
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reach
"Interestingly, we also observed that USP35 could bind to CDH1."
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sparser
"We surmise that Aurora B forms a complex with USP35 and CDH1 during mitosis, whereas USP35 mostly maintains Aurora B levels because the CDK1-dependent ubiquitination of CDH1 inhibits interaction with APC/C in the early phase."
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