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USP35 inhibits NFkappaB. 4 / 6
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"USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaB activation through stabilization of ABIN-2."
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"Functionally, both ABIN-2 and USP35 could inhibit TNFα-induced NF-κB activation and overexpression of ABIN-2 alleviated USP35-loss induced activation of NF-κB. Collectively, our data indicated that miR let-7a-regulated USP35 can inhibit NF-κB activation by deubiquitination and stabilization of ABIN-2 protein and eventually inhibit cell proliferation."
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"XREF_BIBR In addition, miR-let-7a was shown to regulate USP35 expression, which then inhibited NF-kappaB activation by deubiquitination and stabilization of TNIP2 protein."
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"Collectively, our data indicated that miR let-7a-regulated USP35 can inhibit NF-kappaB activation by deubiquitination and stabilization of ABIN-2 protein and eventually inhibit cell proliferation."
26348204