IndraLab

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USP35 inhibits STING1. 7 / 7
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"As mentioned above, USP35 can directly deubiquitinate STING with K6/K11/K27/K29/K63-linked polyubiquitin chains and inhibit STING."
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"Our data further showed that USP35 can directly deubiquitinate and inactivate STING."
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"Literature reports have also confirmed that in ovarian cancer, USP35 can directly de-ubiquitinate and inactivate STING, thereby enhancing the chemoresistance of ovarian cancer cells to chemotherapy drugs and promoting tumor development [ xref ]."
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"Knockdown of USP35 increases the activation of the STING signaling pathway [134] ."
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"In ovarian cancer, USP35 can directly deubiquitinate and inactivate the stimulator of interferon genes protein, decreasing the sensitivity of tumor cells to cisplatin ( xref )."
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"Of note, USP35 negatively regulates STING activity in the DNA-sensing pathway [17]."
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"Previous authors have demonstrated that USP35 negatively regulates STING in the DNA signaling pathway, and our current work demonstrates that USP35 also interacts with MAVS in the RNA signaling pathway."
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