IndraLab

Statements

USP35 inhibits STING1. 6 / 6
| 4 2
reach
"As mentioned above, USP35 can directly deubiquitinate STING with K6/K11/K27/K29/K63-linked polyubiquitin chains and inhibit STING."
35603197
sparser
"Our data further showed that USP35 can directly deubiquitinate and inactivate STING."
32678307
reach
"Knockdown of USP35 increases the activation of the STING signaling pathway [134] ."
37201875
sparser
"In ovarian cancer, USP35 can directly deubiquitinate and inactivate the stimulator of interferon genes protein, decreasing the sensitivity of tumor cells to cisplatin ( xref )."
37594129
reach
"Of note, USP35 negatively regulates STING activity in the DNA-sensing pathway [17]."
40016186
reach
"Previous authors have demonstrated that USP35 negatively regulates STING in the DNA signaling pathway, and our current work demonstrates that USP35 also interacts with MAVS in the RNA signaling pathway."
40016186