IndraLab

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"We then investigated whether USP35 overexpression could potentiate the function of hUC-MSC and hUC-MSC-EV in alleviating apoptosis and reducing ROS stress in SH-SY5Y OGD/R cells."
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"Strikingly, USP35 overexpression markedly reduced cytotoxic agents-induced cell apoptosis (Fig. 2F, G), while USP35 knockdown led to increased drug-induced cell apoptosis (Fig. S3C, D)."
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"USP35 iso2 led to ER stress, BAP31 cleavage and activation of caspase-8 and caspase-3, resulting in apoptosis [XREF_BIBR]."
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