IndraLab

Statements

USP35 binds TNIP2. 8 / 12
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"USP35 acts as a functional DUB and interacts with ABIN-2."
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"The NF-κB inhibition through USP35-ABIN2 interaction leads to the inhibition of cancer cell proliferation in non-small cell lung carcinoma, cervical cancer, and prostate adenocarcinoma ( xref )."
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"To validate the interaction between USP35 and ABIN-2, HEK293T cells were transiently transfected with Myc tagged USP35 alone or in combination with Flag tagged ABIN-2."
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"To validate the interaction between USP35 and ABIN-2, HEK293T cells were transiently transfected with Myc-tagged USP35 alone or in combination with Flag-tagged ABIN-2."
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"Further, to examine if endogenous USP35 could bind to endogenous ABIN-2, lysates of LNCaP cells were immunoprecipitated with anti-ABIN-2 antibody and probed for USP35 by anti-USP35 antibody."
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"In addition, endogenous USP35 binding to ABIN-2 was also observed in HeLa cells."
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"Further, to examine if endogenous USP35 could bind to endogenous ABIN-2, lysates of LNCaP cells were immunoprecipitated with anti-ABIN-2 antibody and probed for USP35 by anti-USP35 antibody."
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"In addition, endogenous USP35 binding to ABIN-2 was also observed in HeLa cells (Figure xref )."
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