IndraLab

Statements


USP35 inhibits PRKN. 4 / 5
| 4

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"For example, USP15, USP30, and USP35 are known to eliminate the ubiquitin- and parkin-mediated signals, consequently delaying or disrupting mitophagy (5)."

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"Parkin mediated effects are further regulated by de-ubiquitinating enzymes, such as USP30 and USP35, which reportedly de-ubiquitinate Parkin substrates to antagonize mitophagy [XREF_BIBR] or Parkin dependent cell death [XREF_BIBR]."

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"USP8, USP14, USP15, USP30, USP33, and USP35 have been shown to antagonize Parkin activity [[92], [93], [94], [95], [96], [97]]."

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"USP35 Inhibits Parkin-Mediated Mitophagy through Mfn2 Stabilization."