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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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MARCHF8 activates USP35. 4 / 4

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"In the present study, we first identified USP35, a member of the USP superfamily, can be up-regulated by the miR let-7a."

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"USP35 activated by miR let-7a inhibits cell proliferation and NF-kappaB activation through stabilization of ABIN-2."

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"These findings indicate that USP35 up-regulated by miR let-7a potentially functions as a tumor suppressor and inhibits tumor growth."

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"The molecular pathways by which miR let-7a up-regulates USP35 need to be further investigated."

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MARCHF8 activates USP35. 4 / 4

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