IndraLab

Statements

ESR1 binds USP35. 3 / 3
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"Results from immunoprecipitation experiment in MCF-7 cells revealed that USP35 and ERα can be reciprocally coimmunoprecipitated (Figs. xref f, xref ), indicating that USP35 interacted with endogenous ERα."
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"Using different deletion mutant of USP35, we found that USP35 interacts with ERα via its USP35 domain (data not shown)."
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"The activated USP35 interacts with ERα, boosting its transcriptional activity, which diminishes the effectiveness of tamoxifen and fulvestrant treatments [ xref ]."
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