IndraLab

Statements

USP53 affects cell population proliferation

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USP53 inhibits cell population proliferation.

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USP53 inhibits cell population proliferation. 9 / 9

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"BrdU cell proliferation assay was also used to test the proliferative ability of cells, and the proliferation of USP53 overexpression cells was inhibited compared with control (Figure 2G,H).3.3 Knockdown USP53 promotes the growth and proliferation of ccRCC."

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"Then, we performed immunohistochemical staining on the tissues of patients with renal clear cell carcinoma and found that the expression of USP53 in tumor tissues was significantly lower than paracancerous tissues (Figure 1F).3.2 Overexpression USP53 inhibits the growth and proliferation of ccRCC."

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"In summary, our data showed that USP53 inhibits ccRCC proliferation and metastasis through NF‐κB pathway inactivation."

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"Our data indicate that USP53 inhibits cancer cell proliferation and migration."

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"Through CCK‐8 assay, we found that overexpression of USP53 in Caki‐1 and 786‐O cells significantly inhibited cell proliferation (Figure 2C,D)."

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"The proliferation and metastasis of ccRCC were significantly inhibited by USP53 in vitro."

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"Functionally, ectopic USP53 expression reduced cell proliferation and cell migration in vitro and vice versa."

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"USP53 suppresses the proliferation and growth of ESCA cells in vitro and in vivo, whereas its knockdown exerts opposite effects."

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"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

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USP53 activates cell population proliferation.

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USP53 activates cell population proliferation. 1 / 1

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"Downregulation of USP53 also promote cell proliferation in vivo."

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USP53 affects DDB2

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DDB2 binds USP53. 8 / 9

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biogrid

No evidence text available

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"XREF_BIBR USP53 interacts with DDB2, but knockdown of USP53 has no effect on DDB2 stability."

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"Interestingly, we also confirmed that USP53 interacts with DDB2 by co-immunoprecipitation ( xref )."

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"Thus, the physiological relevance of USP53-DDB2 interactions is unclear."

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biogrid

No evidence text available

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"Interestingly, we also confirmed that USP53 interacts with DDB2 by co-immunoprecipitation (XREF_FIG)."

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"USP53 interacts with DDB2, but knockdown of USP53 has no effect on DDB2 stability."

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"Damage-specific DNA binding protein 2 (DDB2) is involved in nucleotide excision repair, which can repair DNA damage, and prevent gene mutation and tumorigenesis. xref Zou et al showed that knockdown of DDB2 expression in human lung cancer cells decreases the G2 phase and the repair efficiency of homologous recombination to increase the sensitivity of lung cancer cells to radiotherapy. xref Damage-specific DNA binding protein has been shown to interact with USP53, although the physiological relevance of USP53–DDB2 interactions remains unclear. xref In this study, we knocked down USP53 to provide evidence that the relationship between USP53 and DDB2 increases the radiosensitivity of cervical squamous cell carcinoma."

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USP53 affects FBXO31

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FBXO31 binds USP53. 6 / 6

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"As shown in Fig. xref , USP53 and FBXO31 bound with each other in hBMSCs."

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"Mass spectrometry showed that USP53 interacted with F-box only protein 31 (FBXO31) to promote proteasomal degradation of beta-catenin."

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"To examine whether USP53 interacted with FBXO31 in hBMSCs, co-IP and western blotting were performed using wild-type and mutant FBXO31 (myc-FBXO31DeltaF), the latter of which harbored a deletion of the F-box domain, which mediates binding to Skp1 and Cul1."

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"Additionally, we confirmed that USP53 overexpression promoted osteogenesis in hBMSCs by activating the Wnt and beta-catenin signaling pathway in vitro and that USP53 bound with FBXO31 during the osteogenic differentiation of hBMSCs."

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"To examine whether USP53 interacted with FBXO31 in hBMSCs, co-IP and western blotting were performed using wild-type and mutant FBXO31 (myc-FBXO31ΔF), the latter of which harbored a deletion of the F-box domain, which mediates binding to Skp1 and Cul1."

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"Additionally, we confirmed that USP53 overexpression promoted osteogenesis in hBMSCs by activating the Wnt/β-catenin signaling pathway in vitro and that USP53 bound with FBXO31 during the osteogenic differentiation of hBMSCs."

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SKP1 binds FBXO31, CTNNB1, and USP53. 1 / 1

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"First, we examined the mechanism through which FBXO31 regulated the stability of β-catenin, a key mediator of the Wnt signaling pathway xref and bone formation during osteogenic differentiation xref , using co-IP and western blot assays with wild-type FBXO31 and myc-FBXO31ΔF. As shown in Fig. xref , FBXO31 specifically interacted with β-catenin, Skp1, and USP53."

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USP53 affects CTNNB1

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USP53 activates CTNNB1.

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USP53 activates CTNNB1. 3 / 3

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"In vitro ubiquitination assays showed that beta-catenin degradation was significantly reduced by USP53 overexpression in a concentration dependent manner, whereas downregulation of USP53 promoted the degradation of beta-catenin."

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"Moreover, USP53 increased the half-life of active beta-catenin compared with that in the control group."

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USP53 inhibits CTNNB1.

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USP53 bound to FBXO31 inhibits CTNNB1. 1 / 1

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"Mass spectrometry showed that USP53 interacted with F-box only protein 31 (FBXO31) to promote proteasomal degradation of beta-catenin."

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USP53 inhibits CTNNB1. 1 / 1

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USP53 increases the amount of CTNNB1.

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USP53 increases the amount of CTNNB1. 1 / 1

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"In addition, USP53 overexpression increased the level of active beta-catenin and enhanced the osteogenic differentiation of hBMSCs."

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USP53 binds CTNNB1.

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SKP1 binds FBXO31, CTNNB1, and USP53. 1 / 1

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FBXO31 affects USP53

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FBXO31 binds USP53. 6 / 6

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"As shown in Fig. xref , USP53 and FBXO31 bound with each other in hBMSCs."

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"Mass spectrometry showed that USP53 interacted with F-box only protein 31 (FBXO31) to promote proteasomal degradation of beta-catenin."

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SKP1 binds FBXO31, CTNNB1, and USP53. 1 / 1

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USP53 affects cell differentiation

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USP53 activates cell differentiation.

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USP53 activates cell differentiation. 5 / 5

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"We hypothesized that USP53 may positively regulate the osteogenic differentiation of hBMSCs in vitro and that local delivery of AAV2-USP53 to calvarial defects would thus enhance bone formation."

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"In addition, USP53 overexpression increased the level of active beta-catenin and enhanced the osteogenic differentiation of hBMSCs."

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"Thus, USP53 positively regulated the osteogenic differentiation of hBMSCs."

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"These results suggested that knockdown of USP53 decreased the osteogenic differentiation of hBMSCs."

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"Overexpression of USP53 promoted the osteogenic differentiation of hBMSCs in vitro."

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USP53 inhibits cell differentiation.

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USP53 inhibits cell differentiation. 1 / 1

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"Knockdown of USP53 inhibited the osteogenic differentiation of hBMSCs in vitro."

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USP53 affects ccRCC

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USP53 inhibits ccRCC.

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USP53 inhibits ccRCC. 5 / 5

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"EDU cell proliferation imaging assay and BrdU cell proliferation assay also showed that the proliferation of ccRCC after USP53 knockdown was promoted compare with shGFP (Figure 3E–H).3.4 Overexpression USP53 inhibits migration and invasion of ccRCC."

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"In summary, USP53 inhibits the p65 and p50 complex by deubiquitinating IκBα, and further inhibits the activity of the NF‐κB pathway.3.7 Knockdown USP53 promotes the growth of ccRCC in vivo ."

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"Moreover, USP53 knockdown promoted the ability of clone formation of ccRCC in vivo."

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USP53 activates ccRCC.

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USP53 activates ccRCC. 1 / 1

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"The ability of cell migration and invasion was tested via Transwell assays, we found fewer migrated cells on the Transwell chamber surface compared to the controls after overexpression USP53 (Figure 4C,D), the quantitative results are at the bottom of the picture.3.5 Knockdown USP53 promotes migration and invasion of ccRCC."

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USP53 affects Cholestasis

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USP53 activates Cholestasis.

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USP53 activates Cholestasis. 5 / 5

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"Previous studies identified a new type of normal-GGT cholestasis caused by autosomal recessive pathogenic variants in ubiquitin-specific peptidase 53 (USP53)."

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"However, we cannot be sure that hepatic hemangiomas are the specific symptom of cholestasis caused by mutations in USP53 gene because they are the most common benign liver tumor, the incidence of which ranges from 0.4% to 20% of the total population."

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"In this study, we aimed to characterize clinical findings and biological insights on a novel USP53 splice variant causing cholestasis phenotype and provided a review of the literature."

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"Here, we report a novel truncating mutation in the ubiquitin-specific peptidase gene ( USP53 ) causing low-γ-GT (GGT) cholestasis."

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"Here, we report a novel truncating mutation in the ubiquitin-specific peptidase gene (USP53) causing low-gamma-GT (GGT) cholestasis."

| PMC

USP53 inhibits Cholestasis.

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USP53 inhibits Cholestasis. 1 / 1

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"USP53 deficiency leads to cholestasis, and may be accompanied by hearing impairment or hearing loss in severe cases."

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USP53 affects Neoplasm Invasiveness

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USP53 inhibits Neoplasm Invasiveness.

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USP53 inhibits Neoplasm Invasiveness. 4 / 4

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"Therefore, it can be explained that the gene USP53 can inhibit the migration and invasion of renal cancer cells."

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"The results showed that USP53 knockdown significantly promoted the migration and invasion of renal cancer cells Caki‐1 and 786‐O cells (Figure 5C,D)."

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"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

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USP53 activates Neoplasm Invasiveness.

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USP53 activates Neoplasm Invasiveness. 1 / 1

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USP53 affects glycolytic process

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USP53 inhibits glycolytic process. 4 / 4

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"USP53 also inhibits glycolysis, oxidative metabolism, and mitochondrial dynamics."

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"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling."

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"USP53 also inhibits glycolysis , oxidative metabolism , and mitochondrial dynamics ."

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"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling."

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USP53 affects apoptotic process

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USP53 activates apoptotic process. 4 / 4

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"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling ."

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"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling."

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"Finally, the overexpression of CYCS compensated for the decreased apoptotic rates in cells with USP53 knocked down, suggesting that USP53 induced the apoptosis in HCC cells through the deubiquitination of CYCS."

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"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

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USP53 affects TJP2

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TJP2 binds USP53. 3 / 3

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

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"USP53 interacts with the tight-junction constituent TJP2."

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"USP53 interacts with the tight-junction constituent TJP2."

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TJP1 binds TJP2 and USP53. 1 / 1

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

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USP53 affects Neoplasm Metastasis

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USP53 inhibits Neoplasm Metastasis. 4 / 4

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"In addition, USP53 knockdown promoted ccRCC growth and metastasis."

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"In summary, our data showed that USP53 inhibits ccRCC proliferation and metastasis through NF‐κB pathway inactivation."

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"The proliferation and metastasis of ccRCC were significantly inhibited by USP53 in vitro."

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"In addition , USP53 knockdown promoted ccRCC growth and metastasis ."

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USP53 affects NFASC

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USP53 inhibits NFASC.

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USP53 inhibits NFASC. 2 / 2

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"We described a new mechanism by which USP53 inhibits ccRCC survival via the downregulation of the NF‐κB signaling pathway."

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"Here, we can guess that USP53 may inhibit the NF‐κB pathway by inhibiting the degradation of IκBα."

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USP53 activates NFASC.

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USP53 activates NFASC. 2 / 2

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"34 , 36 USP53 mediate NF‐κB signaling pathway is also used for verification in other tumor contexts."

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"The regulation mechanism of USP53 mediated NF‐κB signaling pathway still needs to be explored then ascertain the functional effects of USP53 in ccRCC."

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TJP2 affects USP53

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TJP2 binds USP53. 3 / 3

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

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"USP53 interacts with the tight-junction constituent TJP2."

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"USP53 interacts with the tight-junction constituent TJP2."

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TJP1 binds TJP2 and USP53. 1 / 1

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

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Methylmercury chloride affects USP53

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Methylmercury chloride decreases the amount of USP53. 3 / 3

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ctd

No evidence text available

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No evidence text available

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No evidence text available

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Bisphenol A affects USP53

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Bisphenol A methylates USP53.

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Bisphenol A methylates USP53. 1 / 1

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ctd

No evidence text available

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Bisphenol A increases the amount of USP53.

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Bisphenol A increases the amount of USP53. 1 / 1

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ctd

No evidence text available

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Bisphenol A decreases the amount of USP53.

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Bisphenol A decreases the amount of USP53. 1 / 1

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ctd

No evidence text available

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USP53 affects SYT1

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USP53 leads to the dephosphorylation of SYT1. 3 / 3

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"USP53 overexpression decreased the phosphorylation of IKKβ and P65 and increase the expression of IκBα."

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"The result showed that USP53 overexpression decreased the phosphorylation of IKKβ and P65 in both Caki‐1 and 786‐O cells."

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"USP53 overexpression decreased the phosphorylation of IKKbeta and P65 in both Caki-1 and 786-O cells, and the expression of IkappaBalpha was increased."

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USP53 affects NACA

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USP53 binds NACA.

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USP53 binds NACA. 2 / 2

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"Binding of NACA to the proximal promoter of Usp53 was confirmed by ChIP-PCR on MC3T3-E1 cells stimulated with PTH (1–34) or vehicle under the same conditions (Fig. xref B)."

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"The ChIP-Seq data indicated the binding of NACA to the proximal region of the Usp53 promoter."

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USP53 activates NACA.

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USP53 activates NACA. 1 / 1

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"Using ChIP-Seq against NACA in parallel with RNA sequencing, we report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of PTH activated NACA in osteoblasts."

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CREB affects USP53

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CREB activates USP53. 3 / 3

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"We then assessed the JUN-CREB activation of the Usp53 cloned fragment in Naca -knockdown cells."

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"The transcriptional activation of the Usp53 promoter by CREB alone, CREB/JUN together or NACA/JUN/CREB combined was completely abolished following the overexpression of 100 ng of DN-PKA expression vector (Fig. xref F)."

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"Our data (Fig. xref C–E) have demonstrated the PTH-induced CREB activation of the Usp53 promoter."

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(+)-JQ1 compound affects USP53

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(+)-JQ1 compound increases the amount of USP53. 3 / 3

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No evidence text available

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No evidence text available

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Progesterone affects USP53

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Progesterone increases the amount of USP53.

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Progesterone increases the amount of USP53. 1 / 1

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No evidence text available

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Progesterone decreases the amount of USP53.

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Progesterone decreases the amount of USP53. 1 / 1

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ctd

No evidence text available

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Hsa-miR-16-5p affects USP53

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Hsa-miR-16-5p decreases the amount of USP53. 2 / 2

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biopax:mirtarbase

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Folic acid affects USP53

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Folic acid increases the amount of USP53.

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Folic acid increases the amount of USP53. 1 / 1

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No evidence text available

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Folic acid demethylates USP53.

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Folic acid demethylates USP53. 1 / 1

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ctd

No evidence text available

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Ethanol affects USP53

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Ethanol increases the amount of USP53. 2 / 2

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No evidence text available

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Dexamethasone affects USP53

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Dexamethasone increases the amount of USP53. 2 / 2

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No evidence text available

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Cisplatin affects USP53

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Cisplatin increases the amount of USP53.

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Cisplatin increases the amount of USP53. 1 / 1

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ctd

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Cisplatin decreases the amount of USP53.

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Cisplatin decreases the amount of USP53. 1 / 1

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ctd

No evidence text available

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Abrine affects USP53

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Abrine increases the amount of USP53.

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Abrine increases the amount of USP53. 1 / 1

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ctd

No evidence text available

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Abrine decreases the amount of USP53.

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Abrine decreases the amount of USP53. 1 / 1

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ctd

No evidence text available

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ZEB1 affects USP53

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ZEB1 binds USP53. 2 / 2

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No evidence text available

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No evidence text available

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USP53 affects cellular respiration

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USP53 inhibits cellular respiration. 2 / 2

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"USP53 also inhibits glycolysis, oxidative metabolism, and mitochondrial dynamics."

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"USP53 also inhibits glycolysis , oxidative metabolism , and mitochondrial dynamics ."

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USP53 affects cell growth

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USP53 inhibits cell growth.

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USP53 inhibits cell growth. 1 / 1

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"Our study reveals that USP53 is activated by H3K27 acetylation and suppresses ESCA progression by regulating cell growth and metabolism."

34919659

USP53 activates cell growth.

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USP53 activates cell growth. 1 / 1

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"To further determine if USP53 mediate cell growth and migration inhibition through NF‐κB signaling pathway, we analyzed the phosphorylation of IKKβ, P65, and IκBα in USP53 overexpression and knockdown cells via immunoblot assays."

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USP53 affects ZEB1

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ZEB1 binds USP53. 2 / 2

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biogrid

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USP53 affects TRAF2

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TRAF2 binds USP53. 2 / 2

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biogrid

No evidence text available

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hprd

No evidence text available

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USP53 affects TJP1

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TJP1 binds TJP2 and USP53. 1 / 1

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

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TJP1 binds USP53. 1 / 1

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

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USP53 affects SLPI

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USP53 activates SLPI. 2 / 2

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"Additionally, knockdown of USP53 decreased ALP and Alizarin Red S staining intensity as well as ALP activity."

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"Overexpression of USP53 enhanced ALP and Alizarin red S staining intensity as well as ALP activity."

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USP53 affects NFKBIA

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USP53 ubiquitinates NFKBIA.

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USP53 leads to the ubiquitination of NFKBIA. 1 / 1

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"In summary, our data indicate that USP53 inhibits the inactivation of the NF-kappaB pathway by reducing the ubiquitination of IkappaBalpha to further inhibit ccRCC proliferation and metastasis."

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USP53 deubiquitinates NFKBIA.

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USP53 leads to the deubiquitination of NFKBIA. 1 / 1

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"As the expression of USP53 increases, the protein expression of IkappaBalpha was also gradually increased and USP53 reduced the ubiquitination of IkappaBalpha."

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USP53 affects NFKB1

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USP53 inhibits NFKB1. 2 / 2

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"USP53 inhibits the p65 and p50 complex by deubiquitinating IκBα, and further inhibits the activity of the NF‐κB pathway."

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"In summary, USP53 inhibits the p65 and p50 complex by deubiquitinating IκBα, and further inhibits the activity of the NF‐κB pathway."

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USP53 affects Mice

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USP53 inhibits Mice.

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USP53 inhibits Mice. 1 / 1

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"USP53 encodes a protein of uncertain function and USP53 deficiency causes deafness in mice."

| PMC

USP53 activates Mice.

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USP53 activates Mice. 1 / 1

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"USP53 encodes a protein of uncertain function and USP53 deficiency causes deafness in mice."

| PMC

USP53 affects IKK_complex

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USP53 leads to the dephosphorylation of IKK_complex. 2 / 2

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"The result showed that USP53 overexpression decreased the phosphorylation of IKKβ and P65 in both Caki‐1 and 786‐O cells."

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"USP53 overexpression decreased the phosphorylation of IKKβ and P65 and increase the expression of IκBα."

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USP53 affects GGT1

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USP53 activates GGT1. 2 / 2

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"Here, we report a novel truncating mutation in the ubiquitin-specific peptidase gene (USP53) causing low-gamma-GT (GGT) cholestasis."

| PMC

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"Here, we report a novel truncating mutation in the ubiquitin-specific peptidase gene ( USP53 ) causing low-γ-GT (GGT) cholestasis."

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USP53 affects Deafness

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USP53 inhibits Deafness.

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USP53 inhibits Deafness. 1 / 1

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"USP53 encodes a protein of uncertain function and USP53 deficiency causes deafness in mice."

| PMC

USP53 activates Deafness.

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USP53 activates Deafness. 1 / 1

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"USP53 encodes a protein of uncertain function and USP53 deficiency causes deafness in mice."

| PMC

TRAF2 affects USP53

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TRAF2 binds USP53. 2 / 2

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biogrid

No evidence text available

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hprd

No evidence text available

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TJP1 affects USP53

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TJP1 binds TJP2 and USP53. 1 / 1

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

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TJP1 binds USP53. 1 / 1

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reach

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

29080116

NACA affects USP53

| 2

USP53 binds NACA. 2 / 2

| 2

➶

sparser

"Binding of NACA to the proximal promoter of Usp53 was confirmed by ChIP-PCR on MC3T3-E1 cells stimulated with PTH (1–34) or vehicle under the same conditions (Fig. xref B)."

33875709

➶

sparser

"The ChIP-Seq data indicated the binding of NACA to the proximal region of the Usp53 promoter."

33875709

H3K27 affects USP53

| 2

H3K27 increases the amount of USP53.

| 1

Acetylated H3K27 increases the amount of USP53. 1 / 1

| 1

➶

reach

"H3K27 acetylation increases USP53 expression by binding to its promoter region."

34919659

H3K27 activates USP53.

| 1

H3K27 activates USP53. 1 / 1

| 1

➶

reach

"USP53 activated by H3K27 acetylation regulates cell viability, apoptosis, and metabolism in esophageal carcinoma via the AMPK signaling pathway."

34919659

H3K27 acetylation affects USP53

| 2

H3K27 acetylation activates USP53. 2 / 2

| 2

➶

eidos

"H3K27 acetylation increases USP53 expression by binding to its promoter region ."

34919659

➶

eidos

"Our study reveals that USP53 is activated by H3K27 acetylation and suppresses ESCA progression by regulating cell growth and metabolism ."

34919659

2,3,7,8-tetrachlorodibenzodioxine affects USP53

2 |

2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP53.

1 |

2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

18691609

2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP53.

1 |

2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

20106945

4,4'-sulfonyldiphenol affects USP53

2 |

4,4'-sulfonyldiphenol increases the amount of USP53. 2 / 2

2 |

➶

ctd

No evidence text available

28628672

➶

ctd

No evidence text available

30951980

Vorinostat affects USP53

1 |

Vorinostat increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Valproic acid affects USP53

1 |

Valproic acid increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

28001369

Urethane affects USP53

1 |

Urethane increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

28818685

Tris(1,3-dichloro-2-propyl)phosphate affects USP53

1 |

Tris(1,3-dichloro-2-propyl)phosphate increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

26179874

Trichostatin A affects USP53

1 |

Trichostatin A increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

26705709

Thioacetamide affects USP53

1 |

Thioacetamide increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

23411599

Silicon dioxide affects USP53

1 |

Silicon dioxide decreases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

25895662

Protein kinase inhibitor affects USP53

| 1

Protein kinase inhibitor inhibits USP53. 1 / 1

| 1

➶

reach

"AMP-activated protein kinase inhibitor reverses the effects of USP53 knockdown."

34919659

Peptidase affects USP53

| 1

Peptidase activates USP53. 1 / 1

| 1

➶

reach

"Retinol binding protein 1 (RBP1) mRNA was upregulated by 2.6-fold in OF, and ubiquitin specific peptidase 53 (USP53) was upregulated by 2.3-fold."

29100496

Paracetamol affects USP53

1 |

Paracetamol increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

26690555

Pantogab affects USP53

1 |

Pantogab increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

17379144

Mercury(0) affects USP53

1 |

Mercury(0) decreases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

25056781

Melphalan affects USP53

1 |

Melphalan decreases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

22363485

Jinfukang affects USP53

1 |

Jinfukang decreases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

27392435

Indometacin affects USP53

1 |

Indometacin increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Hsa-miR-876-3p affects USP53

1 |

Hsa-miR-876-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-6838-5p affects USP53

1 |

Hsa-miR-6838-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-6806-5p affects USP53

1 |

Hsa-miR-6806-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-6792-5p affects USP53

1 |

Hsa-miR-6792-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-6757-3p affects USP53

1 |

Hsa-miR-6757-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-6504-3p affects USP53

1 |

Hsa-miR-6504-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-646 affects USP53

1 |

Hsa-miR-646 decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-5685 affects USP53

1 |

Hsa-miR-5685 decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-559 affects USP53

1 |

Hsa-miR-559 decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548y affects USP53

1 |

Hsa-miR-548y decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548w affects USP53

1 |

Hsa-miR-548w decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548o-5p affects USP53

1 |

Hsa-miR-548o-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548j-5p affects USP53

1 |

Hsa-miR-548j-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548i affects USP53

1 |

Hsa-miR-548i decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548h-5p affects USP53

1 |

Hsa-miR-548h-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548d-5p affects USP53

1 |

Hsa-miR-548d-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548c-5p affects USP53

1 |

Hsa-miR-548c-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548bb-5p affects USP53

1 |

Hsa-miR-548bb-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548b-5p affects USP53

1 |

Hsa-miR-548b-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548ay-5p affects USP53

1 |

Hsa-miR-548ay-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548au-5p affects USP53

1 |

Hsa-miR-548au-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548as-5p affects USP53

1 |

Hsa-miR-548as-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548ar-5p affects USP53

1 |

Hsa-miR-548ar-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548aq-5p affects USP53

1 |

Hsa-miR-548aq-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548ap-5p affects USP53

1 |

Hsa-miR-548ap-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548am-5p affects USP53

1 |

Hsa-miR-548am-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548ak affects USP53

1 |

Hsa-miR-548ak decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548ae-5p affects USP53

1 |

Hsa-miR-548ae-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548ad-5p affects USP53

1 |

Hsa-miR-548ad-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548ab affects USP53

1 |

Hsa-miR-548ab decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-548a-5p affects USP53

1 |

Hsa-miR-548a-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-545-3p affects USP53

1 |

Hsa-miR-545-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-503-5p affects USP53

1 |

Hsa-miR-503-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-497-5p affects USP53

1 |

Hsa-miR-497-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-497-3p affects USP53

1 |

Hsa-miR-497-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-4690-3p affects USP53

1 |

Hsa-miR-4690-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-4524b-5p affects USP53

1 |

Hsa-miR-4524b-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-4524a-5p affects USP53

1 |

Hsa-miR-4524a-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-4456 affects USP53

1 |

Hsa-miR-4456 decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-424-5p affects USP53

1 |

Hsa-miR-424-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-3973 affects USP53

1 |

Hsa-miR-3973 decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-374b-3p affects USP53

1 |

Hsa-miR-374b-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-323a-5p affects USP53

1 |

Hsa-miR-323a-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-3120-3p affects USP53

1 |

Hsa-miR-3120-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23592263

Hsa-miR-30b-5p affects USP53

1 |

Hsa-miR-30b-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-200a-3p affects USP53

1 |

Hsa-miR-200a-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-195-5p affects USP53

1 |

Hsa-miR-195-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-186-3p affects USP53

1 |

Hsa-miR-186-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-15b-5p affects USP53

1 |

Hsa-miR-15b-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-15a-5p affects USP53

1 |

Hsa-miR-15a-5p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

Hsa-miR-141-3p affects USP53

1 |

Hsa-miR-141-3p decreases the amount of USP53. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24398324

HBMSCs affects USP53

| 1

HBMSCs activates USP53. 1 / 1

| 1

➶

reach

"The levels of unphosphorylated beta-catenin were higher in hBMSCs overexpressing USP53 than in the control."

33664230

Formaldehyde affects USP53

1 |

Formaldehyde increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

20655997

Fluoranthene affects USP53

1 |

Fluoranthene increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

28329830

Dioxygen affects USP53

1 |

Dioxygen increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

20880076

Dicrotophos affects USP53

1 |

Dicrotophos decreases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

28302478

Dibutyl phthalate affects USP53

1 |

Dibutyl phthalate increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

21266533

Copper atom affects USP53

1 |

Copper atom increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

20971185

Choline affects USP53

1 |

Choline demethylates USP53. 1 / 1

1 |

➶

ctd

No evidence text available

20938992

Calcitriol affects USP53

1 |

Calcitriol increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

26485663

Bortezomib affects USP53

1 |

Bortezomib increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

20977926

Bisphenol F affects USP53

1 |

Bisphenol F increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

30951980

Aluminium atom affects USP53

1 |

Aluminium atom decreases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

21298039

All-trans-retinoic acid affects USP53

1 |

All-trans-retinoic acid increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

21934132

Aflatoxin B1 affects USP53

1 |

Aflatoxin B1 demethylates USP53. 1 / 1

1 |

➶

ctd

No evidence text available

27153756

Acrylamide affects USP53

1 |

Acrylamide increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

28959563

YAE1 affects USP53

1 |

YAE1 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Ubiquitin affects USP53

| 1

Ubiquitin activates USP53. 1 / 1

| 1

➶

reach

"Retinol binding protein 1 (RBP1) mRNA was upregulated by 2.6-fold in OF, and ubiquitin specific peptidase 53 (USP53) was upregulated by 2.3-fold."

29100496

USP54 affects USP53

| 1

USP54 binds USP53. 1 / 1

| 1

➶

sparser

"Also like Echinus, the USP53 and USP54 long forms are inactive in a deubiquitination assay using a model ubiquitin-β-gal fusion protein substrate [ xref ]."

17612403

USP53 affects wound healing

| 1

USP53 inhibits wound healing. 1 / 1

| 1

➶

reach

"We first examined the repair ability of Caki‐1 and 786‐O cells by wound healing assays; results showed that overexpression of USP53 significantly inhibited the ability of wound healing repair at 12 and 36 h for 786‐O and Caki‐1 (Figure 4A,B)."

33973730

USP53 affects ubiquitination IkappaBalpha

| 1

USP53 inhibits ubiquitination IkappaBalpha. 1 / 1

| 1

➶

eidos

"As the expression of USP53 increases , the protein expression of IkappaBalpha was also gradually increased and USP53 reduced the ubiquitination of IkappaBalpha ."

33973730

USP53 affects proteasome p-catenin

| 1

USP53 inhibits proteasome p-catenin. 1 / 1

| 1

➶

eidos

"USP53 inhibits proteasome degradation of p-catenin by interacting with FBXO31 and enhance Wnt signaling ."

36340031

USP53 affects proteasome beta-catenin

| 1

USP53 inhibits proteasome beta-catenin. 1 / 1

| 1

➶

eidos

"USP53 inhibits proteasome degradation of beta-catenin by interacting with F-box only protein 31 ( FBXO31 ) , thereby promoting osteogenic differentiation of human bone marrow-derived MSCs ( Baek et al ., 2021 ) ."

36340031

USP53 affects osteogenic differentiation human bone marrow-derived MSCs

| 1

USP53 activates osteogenic differentiation human bone marrow-derived MSCs. 1 / 1

| 1

➶

eidos

36340031

USP53 affects metabolic process

| 1

USP53 inhibits metabolic process. 1 / 1

| 1

➶

reach

"Our study reveals that USP53 is activated by H3K27 acetylation and suppresses ESCA progression by regulating cell growth and metabolism."

34919659

USP53 affects hBMSCs

| 1

USP53 activates hBMSCs. 1 / 1

| 1

➶

reach

"qRT-PCR and western blot analysis revealed that osteogenic marker expression levels in USP53 overexpressing hBMSCs were upregulated compared with those in control cells."

33664230

USP53 affects growth cells

| 1

USP53 inhibits growth cells. 1 / 1

| 1

➶

eidos

"USP53 suppresses the proliferation and growth of ESCA cells in vitro and in vivo , whereas its knockdown exerts opposite effects ."

34919659

USP53 affects glycolysis lung adenocarcinoma

| 1

USP53 inhibits glycolysis lung adenocarcinoma. 1 / 1

| 1

➶

eidos

"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling ."

32511815

USP53 affects fate mesenchymal cells

| 1

USP53 activates fate mesenchymal cells. 1 / 1

| 1

➶

eidos

"Our data suggest that Usp53 modulates the fate of mesenchymal cells by impacting lineage selection ."

33875709

USP53 affects estrogen

| 1

USP53 activates estrogen. 1 / 1

| 1

➶

reach

"Furthermore, the roles of USP53 in osteoporosis were examined in an OVX mouse model to induce estrogen deficiency related osteoporosis."

33664230

USP53 affects development cell renal cell carcinoma

| 1

USP53 inhibits development cell renal cell carcinoma. 1 / 1

| 1

➶

eidos

"Ubiquitin-specific peptidase 53 inhibits the occurrence and development of clear cell renal cell carcinoma through NF-kappaB pathway inactivation ."

33973730

USP53 affects clone ccRCC

| 1

USP53 inhibits clone ccRCC. 1 / 1

| 1

➶

eidos

"Moreover , USP53 knockdown promoted the ability of clone formation of ccRCC in vivo ."

33973730

USP53 affects cellular senescence

| 1

USP53 activates cellular senescence. 1 / 1

| 1

➶

reach

"Transient depletion of USP12, USP46, and USP53 did not induce a senescence arrest."

27160904

USP53 affects cell migration

| 1

USP53 inhibits cell migration. 1 / 1

| 1

➶

reach

"Functionally, ectopic USP53 expression reduced cell proliferation and cell migration in vitro and vice versa."

33973730

USP53 affects ccRCC growth

| 1

USP53 inhibits ccRCC growth. 1 / 1

| 1

➶

eidos

"In addition , USP53 knockdown promoted ccRCC growth and metastasis ."

33973730

USP53 affects bone remodeling

| 1

USP53 inhibits bone remodeling. 1 / 1

| 1

➶

reach

"At the cellular level, the ablation of Usp53 perturbs bone remodeling, augments osteoblast-dependent osteoclastogenesis, and increases osteoclast numbers."

36726200

USP53 affects apoptosis cells

| 1

USP53 activates apoptosis cells. 1 / 1

| 1

➶

eidos

"Finally , the overexpression of CYCS compensated for the decreased apoptotic rates in cells with USP53 knocked down , suggesting that USP53 induced the apoptosis in HCC cells through the deubiquitination of CYCS ."

35654790

USP53 affects YAE1

1 |

YAE1 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects Wnt

| 1

USP53 activates Wnt. 1 / 1

| 1

➶

reach

33664230

USP53 affects USP54

| 1

USP54 binds USP53. 1 / 1

| 1

➶

sparser

"Also like Echinus, the USP53 and USP54 long forms are inactive in a deubiquitination assay using a model ubiquitin-β-gal fusion protein substrate [ xref ]."

17612403

USP53 affects USP53

| 1

USP53 decreases the amount of USP53. 1 / 1

| 1

➶

reach

"We further analyzed the expression of USP53 in TCGA‐KIRC database, consistent with GEO's results, the expression of USP53 in ccRCC is reduced (Figure 1B)."

33973730

USP53 affects TRIM25

1 |

TRIM25 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

29117863

USP53 affects TNFSF11

| 1

USP53 decreases the amount of TNFSF11. 1 / 1

| 1

➶

reach

"Usp53 null mice displayed increased serum RANKL levels and Usp53 deficient osteoblasts and bone marrow adipocytes have increased expression of Rankl."

36726200

USP53 affects TGM3

1 |

TGM3 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects SKP1

| 1

SKP1 binds FBXO31, CTNNB1, and USP53. 1 / 1

| 1

➶

sparser

33664230

USP53 affects RPL26

1 |

RPL26 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects RAD50

1 |

USP53 binds RAD50. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects PSMA6

1 |

USP53 binds PSMA6. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects PPP2R1B

1 |

USP53 binds PPP2R1B. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects Neuralgia

| 1

USP53 activates Neuralgia. 1 / 1

| 1

➶

reach

"In summary, this study revealed that USP53 exacerbated CCI‑induced neuropathic pain, potentially via regulation of the FKBP51/RhoA/ROCK pathway."

36748970

USP53 affects NF-kappaB pathway

| 1

USP53 inhibits NF-kappaB pathway. 1 / 1

| 1

➶

eidos

"In summary , our data indicate that USP53 inhibits the inactivation of the NF-kappaB pathway by reducing the ubiquitination of IkappaBalpha to further inhibit ccRCC proliferation and metastasis ."

33973730

USP53 affects NECTIN2

1 |

USP53 binds NECTIN2. 1 / 1

1 |

➶

biogrid

No evidence text available

21988832

USP53 affects Mitochondrial Dynamics

| 1

USP53 inhibits Mitochondrial Dynamics. 1 / 1

| 1

➶

eidos

"USP53 also inhibits glycolysis , oxidative metabolism , and mitochondrial dynamics ."

34919659

USP53 affects KRT77

1 |

KRT77 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects IREB2

1 |

USP53 binds IREB2. 1 / 1

1 |

➶

biogrid

No evidence text available

21988832

USP53 affects IKBKB

| 1

USP53 leads to the dephosphorylation of IKBKB. 1 / 1

| 1

➶

reach

"USP53 overexpression decreased the phosphorylation of IKKbeta and P65 in both Caki-1 and 786-O cells, and the expression of IkappaBalpha was increased."

33973730

USP53 affects HCFC1

1 |

USP53 binds HCFC1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects GRB2

1 |

USP53 binds GRB2. 1 / 1

1 |

➶

biogrid

No evidence text available

20936779

USP53 affects Flag

| 1

USP53 binds Flag. 1 / 1

| 1

➶

sparser

"In order to figure out why USP53 will affect the expression of IκBα, we transfected Myc‐ub, HA‐IκBα, and Flag‐USP53 into 293 cells, and then tested the effect of USP53 on the ubiquitination of IκBα by co‐immunoprecipitation and WB experiments."

33973730

USP53 affects FLNC

1 |

USP53 binds FLNC. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects FKBP4

| 1

USP53 deubiquitinates FKBP4. 1 / 1

| 1

➶

reach

"Mechanistically, USP53 deubiquitinates FKBP51, which in turn dephosphorylates AKT1, and ultimately inhibits tumor growth in lung adenocarcinoma."

32511815

USP53 affects FAM126A

| 1

USP53 activates FAM126A. 1 / 1

| 1

➶

reach

"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

35654790

USP53 affects ESCA

| 1

USP53 inhibits ESCA. 1 / 1

| 1

➶

reach

"Our study reveals that USP53 is activated by H3K27 acetylation and suppresses ESCA progression by regulating cell growth and metabolism."

34919659

USP53 affects DSG1

1 |

USP53 binds DSG1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects DAB1

1 |

DAB1 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

USP53 affects Carcinoma, Renal Cell

| 1

USP53 inhibits Carcinoma, Renal Cell. 1 / 1

| 1

➶

reach

"Ubiquitin-specific peptidase 53 inhibits the occurrence and development of clear cell renal cell carcinoma through NF-kappaB pathway inactivation."

33973730

USP53 affects CYCS

| 1

USP53 activates CYCS. 1 / 1

| 1

➶

reach

"USP53 overexpression increased the stability of CYCS in HCC cells following cycloheximide treatment."

35654790

USP53 affects CSTA

1 |

CSTA binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects CPNE7

1 |

CPNE7 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects CAT

1 |

CAT binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects CASP14

1 |

CASP14 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects Bglap2

| 1

USP53 decreases the amount of Bglap2. 1 / 1

| 1

➶

reach

"Usp53 knockdown in ST2 stromal cells stimulated expression of the osteoblastic markers Bglap2 (Osteocalcin) and Alpl (Alkaline phosphatase) and inhibited expression of the adipogenic markers Pparg and Cebpa."

33875709

USP53 affects BLMH

1 |

BLMH binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects AZGP1

1 |

USP53 binds AZGP1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects ARG1

1 |

USP53 binds ARG1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects ANXA2P2

1 |

USP53 binds ANXA2P2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP53 affects ALPL

| 1

USP53 decreases the amount of ALPL. 1 / 1

| 1

➶

reach

33875709

USP53 affects 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid

| 1

USP53 activates 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid. 1 / 1

| 1

➶

reach

"Additionally, knockdown of USP53 decreased ALP and Alizarin Red S staining intensity as well as ALP activity."

33664230

Tobacco Smoke Pollution affects USP53

1 |

Tobacco Smoke Pollution increases the amount of USP53. 1 / 1

1 |

➶

ctd

No evidence text available

18087596

TRIM25 affects USP53

1 |

TRIM25 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

29117863

TJP2 affects TJP1

| 1

TJP1 binds TJP2 and USP53. 1 / 1

| 1

➶

sparser

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

29080116

TGM3 affects USP53

1 |

TGM3 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SKP1 affects USP53

| 1

SKP1 binds FBXO31, CTNNB1, and USP53. 1 / 1

| 1

➶

sparser

33664230

RPL26 affects USP53

1 |

RPL26 binds USP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RAD50 affects USP53

1 |

USP53 binds RAD50. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PTH affects USP53

| 1

PTH activates USP53. 1 / 1

| 1

➶

sparser

"The mutation abrogated the PTH-induced activation of the cloned Usp53 fragment, resulting in > 50% reduction in the promoter activity (Fig. xref A, grey bars )."

33875709