IndraLab

Statements

USP51 affects ZEB1
8 1 | 1 22 7
USP51 binds ZEB1.
8 | 1 7
USP51 binds ZEB1. 10 / 16
8 | 1 7
biogrid
No evidence text available
29119051
sparser
"Rather, the co-IP assay demonstrated that USP51 interacted with ZEB1 in A549/DDP cells ( xref ), and that USP51 knockdown promoted the ubiquitination and degradation of the ZEB1 protein ( xref )."
32468048
reach
"By contrast, ubiquitin-specific peptidase 51 (USP51) binds to ZEB1 and promotes its ubiquitination and stability, thus supporting invasion by breast cancer cells [ 96 ]."
37328395
sparser
"USP51 interacted with ZEB1, and knockdown of USP51 markedly induced ubiquitin-mediated degradation of ZEB1."
32468048
sparser
"Additionally, co-immunoprecipitation assays indicated a physical interaction between USP51 and ZEB1 under sparse conditions (Supplementary Fig. xref ), suggesting that USP51 directly interacted with and deubiquitinated ZEB1 protein."
40877392
biogrid
No evidence text available
32296027
sparser
"Additionally, USP51 can interact with ZEB1, and the reduction of USP51 levels increases ZEB1 ubiquitination, significantly lowering cisplatin resistance in lung cancer cells [ xref ]."
38702734
sparser
"Over-expression of CDK6 causes the hyperphosphorylation of USP51 protein, causing its structural alteration and functional inactivation, and hence, USP51 protein cannot interact with ZEB1 protein [105[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35878668
biogrid
No evidence text available
32296027
sparser
"As shown in Fig. 5 L-M, there was a strong positive correlation between USP51, ZEB1, and ACTA2 at the protein level (USP51-ZEB1, r = 0.652, P < 0.001; ACTA2-ZEB1, r = 0.563, P < 0.001)."
36603607
USP51 deubiquitinates ZEB1.
1 | 9
USP51 deubiquitinates ZEB1. 10 / 10
1 | 9
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"However, deubiquitination of ZEB1 by the ubiquitin-specific protease-51 (USP51) promotes its stabilization [96] ."
38503384
ubibrowser
"By screening a human deubiquitinase library, we identified <span class="match term0">USP51</span> as a deubiquitinase that binds, deubiquitinates, and stabilizes <span class="match term1">ZEB1</span>."
29119051
reach
"Additionally, USP51 can interact with ZEB1, and the reduction of USP51 levels increases ZEB1 ubiquitination, significantly lowering cisplatin resistance in lung cancer cells [46]."
38702734
reach
"They found that CDK4/6 phosphorylate and activate the deubiquitinase USP51, which is necessary for ZEB1 deubiquitination and stabilization."
39196911
reach
"Lastly, knockdown of USP51 promoted ZEB1 ubiquitination, leading to ZEB1 degradation."
32468048
reach
"Consistently, USP51 deubiquitinates ZEB1 resulting in a poor prognosis in breast cancer patients [241]."
36694209
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"USP51 promotes deubiquitination and stabilization of ZEB1."
29119051
reach
"In addition, USP51 deubiquitinates and stabilizes the ZEB1 protein."
35454770
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"For example, USP51 promotes the deubiquitylation and stabilization of ZEB1 in breast cancer cells [40], PRMT1 activates the transcription of ZEB1 by mediating dimethylation at arginine 3 of histone H4 (H4R3me2) [41], and the DNA methyltransferase inhibitor 5-Aza-2’-deoxycytidine can effectively restore the expression of ZEB1 target genes [42]."
40038747
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"USP51, as a deubiquitinating enzyme, promotes the proliferation and invasion of endometrial cancer cells [48] and the deubiquitination and stabilization of ZEB1 in breast cancer cells [49] ."
33189611
USP51 activates ZEB1.
| 1 9
USP51 activates ZEB1. 10 / 10
| 1 9
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"Conversely, overexpression of USP51 in epithelial cells resulted in upregulation of ZEB1 and mesenchymal markers."
29119051
reach
"Among DUBs, ubiquitin specific peptidase 51 (USP51) binds to the N-terminal of ZEB1 and increases ZEB1 protein stability in breast cancer cell lines [XREF_BIBR]."
33808323
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"In vitro , ectopic expression of USP51 up-regulates Zeb1 and the mesenchymal markers N-cadherin and Vimentin [ 77 ]."
30453041
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"Unsupervised heatmap clustering revealed cluster 12 and 14 to have close homology in terms of the high expression of USP51 and CASP8AP2 which are both known to promote ZEB1 protein stabilization [30, 31] (Supplementary Fig. 3B)."
38191418
reach
"USP51 depletion inhibited the invasion of mesenchymal-like breast cancer cells by downregulating ZEB1 protein and mesenchymal marker expression and promoting E-cadherin upregulation."
39196911
reach
"On the other hand, overexpression of USP51 led to the upregulation of ZEB1 and mesenchymal markers in epithelial cells [13]."
39196911
eidos
"Thus , the deubiquitinases ( DUBs ) were involved in counteracting polyubiquitination and proteasomal degradation of ZEB1 [ 40 ] ; these DUBs include USP51 , which upregulated ZEB1 and the mesenchymal markers by binding , deubiquitinating , and stabilizing ZEB1 [ 41 ] ."
32014049
reach
"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."
35058607
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"ZEB1 has illustrated to be modulated by USP7, USP22 and USP51 in cancers."
38577450
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"Intriguingly, the loss of USP51 deubiquitinase decreases the half-life of endogenous ZEB1 protein, whereas MG132 induces the polyubiquitination of ZEB1 in LM2 cells (a lung metastatic subline of MDA-MB-231 cells) [91]."
35454770
USP51 increases the amount of ZEB1.
| 2
USP51 increases the amount of ZEB1. 2 / 2
| 2
reach
"It was found that USP51 and constitutively photomorphogenic 9 signalosome subunit 5 promote EMT by stabilizing the expression of ZEB1, leading to increased tumor invasion and metastasis [27]."
38449391
reach
"In addition, knockdown of USP51 in A549 and DDP cells significantly induced apoptosis, decreased ZEB1 expression and increased cleaved poly ADP-ribose polymerase 1 (PARP1) and cleaved caspase-3 levels."
32468048
USP51 inhibits ZEB1.
| 1
USP51 inhibits ZEB1. 1 / 1
| 1
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"It has been reported that the upregulation of USP51 inhibits the degradation of ZEB1 and is correlated with poor survival of breast cancer patients."
35760282
ZEB1 affects USP51
1 8 | 4 7
ZEB1 binds USP51.
8 | 1 7
USP51 binds ZEB1. 10 / 16
8 | 1 7
biogrid
No evidence text available
29119051
sparser
"Rather, the co-IP assay demonstrated that USP51 interacted with ZEB1 in A549/DDP cells ( xref ), and that USP51 knockdown promoted the ubiquitination and degradation of the ZEB1 protein ( xref )."
32468048
reach
"By contrast, ubiquitin-specific peptidase 51 (USP51) binds to ZEB1 and promotes its ubiquitination and stability, thus supporting invasion by breast cancer cells [ 96 ]."
37328395
sparser
"USP51 interacted with ZEB1, and knockdown of USP51 markedly induced ubiquitin-mediated degradation of ZEB1."
32468048
sparser
"Additionally, co-immunoprecipitation assays indicated a physical interaction between USP51 and ZEB1 under sparse conditions (Supplementary Fig. xref ), suggesting that USP51 directly interacted with and deubiquitinated ZEB1 protein."
40877392
biogrid
No evidence text available
32296027
sparser
"Additionally, USP51 can interact with ZEB1, and the reduction of USP51 levels increases ZEB1 ubiquitination, significantly lowering cisplatin resistance in lung cancer cells [ xref ]."
38702734
sparser
"Over-expression of CDK6 causes the hyperphosphorylation of USP51 protein, causing its structural alteration and functional inactivation, and hence, USP51 protein cannot interact with ZEB1 protein [105[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35878668
biogrid
No evidence text available
32296027
sparser
"As shown in Fig. 5 L-M, there was a strong positive correlation between USP51, ZEB1, and ACTA2 at the protein level (USP51-ZEB1, r = 0.652, P < 0.001; ACTA2-ZEB1, r = 0.563, P < 0.001)."
36603607
ZEB1 activates USP51.
| 2
ZEB1 activates USP51. 2 / 2
| 2
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"Notably, overexpression of ZEB1 in A549 and DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."
32468048
reach
"Notably, ZEB1 overexpression potently diminishes the effects of USP51 knockdown in these cells [95]."
35454770
ZEB1 increases the amount of USP51.
| 1
Unubiquitinated ZEB1 increases the amount of USP51. 1 / 1
| 1
reach
"95 Similarly, Zhou et al. found that USP51 overexpression promoted breast cancer EMT by deubiquitination and stabilization of ZEB1."
36808651
ZEB1 decreases the amount of USP51.
1 |
ZEB1 decreases the amount of USP51. 1 / 1
1 |
biopax:msigdb
No evidence text available
USP51 affects TWIST1
1 | 12 2
USP51 deubiquitinates TWIST1.
| 7
USP51 deubiquitinates TWIST1. 7 / 7
| 7
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"USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1."
37422632
reach
"We found that USP51 deubiquitinates TWIST1, which is significantly upregulated in the tissues of patients with NSCLC and is closely associated with poor prognosis."
37422632
reach
"Our results show that USP51 maintains the stemness of NSCLC cells by deubiquitinating TWIST1."
37422632
reach
"Mechanistically, USP51 interacted with and deubiquitinated TWIST1, leading to TWIST1 protein stabilization."
37422632
reach
"USP51 deubiquitinates TWIST1."
37422632
reach
"USP51 interacted with TWIST1, and the ectopic USP51 expression decreased the polyubiquitination of TWIST1 in HCC827 cells in the presence of MG132 (Sigma, M7449), a specific inhibitor of proteasome activity (Fig. 5A)."
37422632
reach
"Overall, this study shows that USP51 deubiquitinates TWIST1 to maintain NSCLC cells’ stemness."
38139368
USP51 binds TWIST1.
1 | 3 2
TWIST1 binds USP51. 6 / 6
1 | 3 2
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"Mechanistically, USP51 interacted with and deubiquitinated TWIST1, leading to TWIST1 protein stabilization."
37422632
reach
"USP51 binds to TWIST1, and its expression correlates with stemness marker expression in NSCLC patients."
37422632
biogrid
No evidence text available
37422632
reach
"In conclusion, USP51 interacted with and stabilized TWIST1 by suppressing its polyubiquitination and degradation."
37422632
sparser
"USP51 binds to TWIST1, and its expression correlates with stemness marker expression in NSCLC patients."
37422632
sparser
"USP51 interacted with TWIST1, and the ectopic USP51 expression decreased the polyubiquitination of TWIST1 in HCC827 cells in the presence of MG132 (Sigma, M7449), a specific inhibitor of proteasome activity (Fig.  xref A)."
37422632
USP51 increases the amount of TWIST1.
| 1
USP51 increases the amount of TWIST1. 1 / 1
| 1
reach
"In addition, we found that knockdown of USP51 in NSCLC cells did not reduce the TWIST1 mRNA level, but did reduce the TWIST1 protein level, indicating that USP51 is not involved in the transcriptional and pretranslational regulation of TWIST1."
37422632
USP51 activates TWIST1.
| 1
USP51 activates TWIST1. 1 / 1
| 1
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"In summary, USP51 enhances the tumorigenic ability of NSCLC cells in mice by stabilizing TWIST1."
37422632
Cdk-4 affects USP51
| 5 9
Cdk-4 phosphorylates USP51.
| 4 6
Cdk-4 phosphorylates USP51. 9 / 9
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sparser
"Further research showed that CDK4/6 phosphorylation of USP51 is required for ZEB1-mediated metastasis in LUAD and BC in vitro and in vivo xref , xref ."
41208892
sparser
"They found that CDK4/6 phosphorylate and activate the deubiquitinase USP51 , which is necessary for ZEB1 deubiquitination and stabilization."
39196911
sparser
"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."
32195004
sparser
"CDK4/6 kinases phosphorylate and stimulate deubiquitinase USP51, which stabilises ZEB1 [ xref ] (Fig. xref )."
37259089
reach
"Mechanistically, CDK4/6 deubiquitinates and stabilizes ZEB1 by activating and phosphorylating USP51."
37328395
sparser
"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."
32296027
reach
"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."
32195004
reach
"In terms of molecular mechanism, USP51 is phosphorylated and activated by CDK4/6, thus resulting in the deubiquitination and stabilization of ZEB1 protein."
35058607
reach
"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."
32296027
Cdk-4 phosphorylates USP51 on S26. 1 / 1
| 1
sparser
"CDK4/6 induces the post-translational phosphorylation of USP51 at serine 26 in breast cancer cells, significantly promoting to the acquisition of deubiquitinating activity of USP51 xref ."
40877392
Cdk-4 binds USP51.
| 2
USP51 binds cdk-4. 2 / 2
| 2
sparser
"CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB1."
35058607
sparser
"However, the relationship between CDK4/6-USP51 and ZEB1 remains unclear."
40877392
Cdk-4 activates USP51.
| 1 1
Cdk-4 activates USP51. 2 / 2
| 1 1
sparser
"They found that CDK4/6 phosphorylate and activate the deubiquitinase USP51 , which is necessary for ZEB1 deubiquitination and stabilization."
39196911
reach
"Similarly, ZEB1 was validated as a target of USP51 in NSCLC, and CDK4/6 was found to activate USP51 [21]."
37422632
USP51 is modified
1 | 3 9 1
USP51 is phosphorylated.
1 | 9 1
USP51 is phosphorylated. 9 / 9
| 8 1
rlimsp
"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."
32296027
sparser
"Mechanistically, CDK4/6 deubiquitinates and stabilizes ZEB1 by activating and phosphorylating USP51."
37328395
sparser
"CDK4/6 kinases phosphorylate and stimulate deubiquitinase USP51, which stabilises ZEB1 [ xref ] (Fig. xref )."
37259089
sparser
"Moreover, we found a strong positive correlation between the expression of p -RB (an indicator of CDK4/6 activity), p -USP51 and ZEB1 in metastatic human breast cancer samples."
32195004
sparser
"Notably, the high expression of p -RB, p -USP51, and ZEB1 was significantly correlated with a poor clinical outcome."
32195004
sparser
"They found that CDK4/6 phosphorylate and activate the deubiquitinase USP51 , which is necessary for ZEB1 deubiquitination and stabilization."
39196911
sparser
"In terms of molecular mechanism, USP51 is phosphorylated and activated by CDK4/6, thus resulting in the deubiquitination and stabilization of ZEB1 protein."
35058607
sparser
"Over-expression of CDK6 causes the hyperphosphorylation of USP51 protein, causing its structural alteration and functional inactivation, and hence, USP51 protein cannot interact with ZEB1 protein [105[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35878668
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
USP51 is phosphorylated on S26. 2 / 2
1 | 1
sparser
"CDK4/6 induces the post-translational phosphorylation of USP51 at serine 26 in breast cancer cells, significantly promoting to the acquisition of deubiquitinating activity of USP51 xref ."
40877392
hprd
No evidence text available
19664994
USP51 is deubiquitinated.
| 3
USP51 is deubiquitinated. 3 / 3
| 3
trips
"CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism."
32195004
trips
"CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism."
32296027
trips
"Correction to: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism."
34145216
ATXN7L3 affects USP51
7 | 4 3
ATXN7L3 binds USP51.
7 | 3 3
USP51 binds ATXN7L3. 10 / 10
7 | 3
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"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
24981860
reach
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
33961781
biogrid
No evidence text available
27132940
reach
"Like USP22, USP27X and USP51 also form complexes with ATXN7L3 and ENY2 and harbor virtually identical catalytic domains ( Atanassov et al., 2016 )."
35452621
biogrid
No evidence text available
27132940
ATXN7L3 binds ENY2 and USP51. 2 / 2
| 2
sparser
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
sparser
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
ATXN7L3 deubiquitinates USP51.
| 1
ATXN7L3 deubiquitinates USP51. 1 / 1
| 1
reach
"Our results now reveal that in addition to USP22, ATXN7L3 and ENY2 activate two previously uncharacterized deubiquitinating enzymes, USP27X and USP51, which are not part of SAGA."
27132940
ENY2 affects USP51
5 | 4 3
ENY2 binds USP51.
5 | 3 3
ENY2 binds USP51. 8 / 8
5 | 3
biogrid
No evidence text available
33961781
biogrid
No evidence text available
27132940
biogrid
No evidence text available
27132940
biogrid
No evidence text available
27132940
reach
"Like USP22, USP27X and USP51 also form complexes with ATXN7L3 and ENY2 and harbor virtually identical catalytic domains ( Atanassov et al., 2016 )."
35452621
biogrid
No evidence text available
24981860
reach
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."
27132940
reach
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
ATXN7L3 binds ENY2 and USP51. 2 / 2
| 2
sparser
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
sparser
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
ENY2 deubiquitinates USP51.
| 1
ENY2 deubiquitinates USP51. 1 / 1
| 1
reach
"Our results now reveal that in addition to USP22, ATXN7L3 and ENY2 activate two previously uncharacterized deubiquitinating enzymes, USP27X and USP51, which are not part of SAGA."
27132940
USP51 affects Parkinson Disease
| 9
USP51 deubiquitinates Parkinson Disease.
| 6
USP51 deubiquitinates Parkinson Disease on L1. 2 / 2
| 2
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"Indeed, USP51 was able to deubiquitinate PD‐L1 at either K280 or K281 lysine residue (Figure 5H)."
37386737
reach
"Consistently, the ubiquitination assay revealed that USP51 deubiquitinase inhibition by treatment with DHM led to increased polyubiquitination of PD‐L1 proteins in USP51/A549 cells (Supplementary Figure S20B)."
37386737
USP51 deubiquitinates Parkinson Disease on lysine. 2 / 2
| 2
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"In addition, three deletion constructs of PD‐L1‐C were generated to demonstrate that the deletion variant PD‐L1‐C3, but not PD‐L1‐C1 and PD‐L1‐C2, was able to interact with USP51 (Figure 5E), highlighting that the PD‐L1C‐terminal region (280‐290aa) is critical for the USP51‐PD‐L1 association.Next, we examined whether USP51 could deubiquitinate the lysine residues of PD‐L1‐C3."
37386737
reach
"Indeed, USP51 was able to deubiquitinate PD‐L1 at either K280 or K281 lysine residue (Figure 5H)."
37386737
USP51 deubiquitinates Parkinson Disease on K280. 1 / 1
| 1
reach
"Indeed, USP51 was able to deubiquitinate PD‐L1 at either K280 or K281 lysine residue (Figure 5H)."
37386737
USP51 deubiquitinates Parkinson Disease on C3. 1 / 1
| 1
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"In addition, three deletion constructs of PD‐L1‐C were generated to demonstrate that the deletion variant PD‐L1‐C3, but not PD‐L1‐C1 and PD‐L1‐C2, was able to interact with USP51 (Figure 5E), highlighting that the PD‐L1C‐terminal region (280‐290aa) is critical for the USP51‐PD‐L1 association.Next, we examined whether USP51 could deubiquitinate the lysine residues of PD‐L1‐C3."
37386737
USP51 binds Parkinson Disease and A549. 1 / 1
| 1
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"The results revealed that USP51 directly associated with PD‐L1 in A549 cells, which was further increased in A549 cells (Figure 5A)."
37386737
USP51 binds Parkinson Disease and lysine residues K280. 1 / 1
| 1
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"At the molecular level, USP51 directly bound and deubiquitinated PD‐L1 at lysine residues K280 and K281."
37386737
USP51 inhibits Parkinson Disease.
| 1
USP51 inhibits Parkinson Disease. 1 / 1
| 1
reach
"Based on our ubiquitination assay, USP51 depletion strongly enhanced PD‐L1 protein polyubiquitination in A549 cells (Figure 4F), collectively suggesting that USP51, a deubiquitinase, targeted PD‐L1 protein for deubiquitination and stabilization."
37386737
USP51 affects DGCR8
2 1 | 1 5
USP51 binds DGCR8.
2 | 5
DGCR8 binds USP51. 7 / 7
2 | 5
sparser
"To validate the direct interaction between USP51 and DGCR8, we expressed and purified SFB-USP51 and MBP-DGCR8 proteins, and in vitro pulldown assays demonstrated that USP51 bound to DGCR8 (Fig.  xref ), indicating that DGCR8 may be directly regulated by USP51."
34188037
biogrid
No evidence text available
34188037
sparser
"Moreover, the interaction between DGCR8 and USP51 was enhanced in a time-dependent manner after irradiation of LM2 cells (Supplementary Fig.  xref ), and this increased interaction was observed with endogenous proteins (Fig.  xref )."
34188037
sparser
"Furthermore, our results demonstrate that USP51 directly binds and deubiquitinates DGCR8 in a K48 linkage-specific manner, and that this deubiquitination is enhanced by IR treatment."
34188037
biogrid
No evidence text available
34188037
sparser
"Consistent with the results in Supplementary Fig.  xref , the interaction between WT DGCR8 and USP51 was enhanced at 8 h, but not at 1 h, after IR, and this increased interaction was abolished by the phosphodeficient mutation (S677A), but not by the phosphomimetic mutation (S677D) (Fig.  xref )."
34188037
sparser
"Collectively, these results suggest that after irradiation, ATM-dependent phosphorylation of DGCR8 at S677 is crucial for the recruitment of the DGCR8-RNF168 complex to MDC1 and RNF8 at DSBs, as well as the subsequent interaction of DGCR8 with USP51, DGCR8 deubiquitination, histone ubiquitination, and DSB repair."
34188037
USP51 deubiquitinates DGCR8.
1 |
USP51 deubiquitinates DGCR8. 1 / 1
1 |
ubibrowser
"Upon radiation, the kinase ATM and the deubiquitinase <span class="match term0">USP51</span> mediate the activation and stabilization of <span class="match term1">DGCR8</span> through phosphorylation and deubiquitination"
34188037
USP51 activates DGCR8.
| 1
USP51 activates DGCR8. 1 / 1
| 1
reach
"Upon radiation, the kinase ATM and the deubiquitinase USP51 mediate the activation and stabilization of DGCR8 through phosphorylation and deubiquitination."
34188037
TWIST1 affects USP51
1 | 5 2
TWIST1 binds USP51.
1 | 3 2
TWIST1 binds USP51. 6 / 6
1 | 3 2
reach
"Mechanistically, USP51 interacted with and deubiquitinated TWIST1, leading to TWIST1 protein stabilization."
37422632
reach
"USP51 binds to TWIST1, and its expression correlates with stemness marker expression in NSCLC patients."
37422632
biogrid
No evidence text available
37422632
reach
"In conclusion, USP51 interacted with and stabilized TWIST1 by suppressing its polyubiquitination and degradation."
37422632
sparser
"USP51 binds to TWIST1, and its expression correlates with stemness marker expression in NSCLC patients."
37422632
sparser
"USP51 interacted with TWIST1, and the ectopic USP51 expression decreased the polyubiquitination of TWIST1 in HCC827 cells in the presence of MG132 (Sigma, M7449), a specific inhibitor of proteasome activity (Fig.  xref A)."
37422632
TWIST1 inhibits USP51.
| 2
TWIST1 inhibits USP51. 2 / 2
| 2
reach
"In addition, TWIST1 re-expression in NSCLC cells reversed the inhibitory effect of USP51 knockdown on cell stemness."
37422632
reach
"Overall, these results indicate that overexpression of TWIST1 attenuates the inhibitory effects of USP51 depletion on the proliferation and stemness of NSCLC cells."
37422632
USP51 affects Neoplasms
| 7
USP51 activates Neoplasms.
| 6
USP51 activates Neoplasms. 6 / 6
| 6
reach
"Finally, USP51 knockdown weakened cisplatin resistance in A549/DDP cells and significantly suppressed tumor growth in vivo, suggesting that a USP51 inhibitor combined with cisplatin may be considered as an effective treatment strategy to eliminate drug-resistant lung cancer cells."
35856403
reach
"In line, using BALB/c nude mice xenograft model, we confirmed that USP51 knockdown severely inhibited tumor growth upon DDP treatment, which was suppressed in mice with PD‐L1‐harboring tumors (Figure 4L‐M)."
37386737
reach
"The results of loss-of-function studies suggested that USP51 knockdown reduced the expression of stemness markers in NSCLC cells, thereby diminishing the growth and tumor sphere formation of NSCLC cells."
37422632
reach
"Since the above results have shown that USP51 overexpression promotes the transformation of tumors to a mesenchymal-like phenotype, pathological sections directly confirmed that samples with high USP5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
reach
"These findings suggested that increased activation of USP51 signaling could increase the chance of tumor immune escape and resistance to immunotherapy in GC patients.Gastric cancer (GC) is considered [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
reach
"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."
35058607
USP51 inhibits Neoplasms.
| 1
USP51 inhibits Neoplasms. 1 / 1
| 1
reach
"The Overexpression of USP51 mitigated the downregulation of GPX4 induced by BBM.BBM significantly inhibited tumor xenograft growth in nude mice."
39151312
USP51 affects H2AC20
2 1 | 4
USP51 binds H2AC20.
2 | 4
USP51 binds H2AC20. 6 / 6
2 | 4
biogrid
No evidence text available
27083998
biogrid
No evidence text available
27083998
sparser
"To test whether USP51 is an H2AK13,15ub DUB, we first tested whether USP51 can bind to histone H2A. Purified His-tagged USP51 was used to pull down recombinant H2A–H2B dimers in vitro."
27083998
sparser
"His-USP51 bound to H2A, but His-tagged Asf1, a histone H3–H4 chaperone, did not ( xref A), suggesting that USP51 bound to H2A in vitro."
27083998
sparser
"Third, USP51 interacts with H2A and removes H2AK15ub but not H2AK119ub in vitro."
27083998
sparser
"USP51 binds to H2A and deubiquitylates H2AK13,15ub in vitro."
27083998
USP51 deubiquitinates H2AC20.
1 |
USP51 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"<span class="match term0">USP51</span> deubiquitylates H2AK13,15ub and regulates DNA damage response."
27083998
USP51 affects FAT4
2 | 4 1
USP51 binds FAT4.
2 | 2 1
FAT4 binds USP51. 5 / 5
2 | 2 1
biogrid
No evidence text available
31217854
biogrid
No evidence text available
31217854
reach
"FAT4 and USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway."
31217854
sparser
"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4's function in EC."
31217854
reach
"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4 's function in EC."
31217854
USP51 increases the amount of FAT4.
| 1
Modified USP51 increases the amount of FAT4. 1 / 1
| 1
reach
"Ablating USP51 by shRNA decreased cellular FAT4 protein level while overexpression of USP51 increased FAT4 protein level."
31217854
USP51 decreases the amount of FAT4.
| 1
USP51 decreases the amount of FAT4. 1 / 1
| 1
reach
"Ablating USP51 by shRNA decreased cellular FAT4 protein level while overexpression of USP51 increased FAT4 protein level."
31217854
USP51 affects ELOC
4 | 3
USP51 binds ELOC. 7 / 7
4 | 3
reach
"Mechanically, USP51 directly binds to Elongin C (ELOC) and forms a larger functional complex with VHL E3 ligase (USP51/VHL/CUL2/ELOB/ELOC/RBX1) to regulate the ubiquitin-dependent proteasomal degradation of HIF1A."
37816999
reach
"The deSUMOylation of ELOC induced by SENP1 promoted USP51 bind to ELOC and facilitated the deubiquitylation and stabilization of HIF-1α, consequently enhancing colorectal cancer cells stemness (Mu et al., 2023)."
38389923
reach
"SUMO-specific protease 1 (SENP1) mediates the deSUMOylation of ELOC, promoting the binding of USP51 to ELOC and facilitating the deubiquitination and stabilization of HIF1A by USP51."
37816999
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999
DGCR8 affects USP51
2 | 5
DGCR8 binds USP51. 7 / 7
2 | 5
sparser
"To validate the direct interaction between USP51 and DGCR8, we expressed and purified SFB-USP51 and MBP-DGCR8 proteins, and in vitro pulldown assays demonstrated that USP51 bound to DGCR8 (Fig.  xref ), indicating that DGCR8 may be directly regulated by USP51."
34188037
biogrid
No evidence text available
34188037
sparser
"Moreover, the interaction between DGCR8 and USP51 was enhanced in a time-dependent manner after irradiation of LM2 cells (Supplementary Fig.  xref ), and this increased interaction was observed with endogenous proteins (Fig.  xref )."
34188037
sparser
"Furthermore, our results demonstrate that USP51 directly binds and deubiquitinates DGCR8 in a K48 linkage-specific manner, and that this deubiquitination is enhanced by IR treatment."
34188037
biogrid
No evidence text available
34188037
sparser
"Consistent with the results in Supplementary Fig.  xref , the interaction between WT DGCR8 and USP51 was enhanced at 8 h, but not at 1 h, after IR, and this increased interaction was abolished by the phosphodeficient mutation (S677A), but not by the phosphomimetic mutation (S677D) (Fig.  xref )."
34188037
sparser
"Collectively, these results suggest that after irradiation, ATM-dependent phosphorylation of DGCR8 at S677 is crucial for the recruitment of the DGCR8-RNF168 complex to MDC1 and RNF8 at DSBs, as well as the subsequent interaction of DGCR8 with USP51, DGCR8 deubiquitination, histone ubiquitination, and DSB repair."
34188037
USP51 affects USP27X
2 | 4
USP27X binds USP51. 2 / 2
| 2
sparser
"Interestingly, one of the USP27X and USP51 associated proteins, C1QBP, was originally described as a mitochondrial protein ( xref )."
27132940
sparser
"The reduced tumor burden upon depletion of USP27X prompted us to search the The Cancer Genome Atlas (TCGA) database to see if altered expression of USP27X or USP51 is associated with certain cancer phenotypes."
27132940
USP27X binds USP51. 2 / 2
2 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
33961781
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
H2AC20 affects USP51
2 | 4
USP51 binds H2AC20. 6 / 6
2 | 4
biogrid
No evidence text available
27083998
biogrid
No evidence text available
27083998
sparser
"To test whether USP51 is an H2AK13,15ub DUB, we first tested whether USP51 can bind to histone H2A. Purified His-tagged USP51 was used to pull down recombinant H2A–H2B dimers in vitro."
27083998
sparser
"His-USP51 bound to H2A, but His-tagged Asf1, a histone H3–H4 chaperone, did not ( xref A), suggesting that USP51 bound to H2A in vitro."
27083998
sparser
"Third, USP51 interacts with H2A and removes H2AK15ub but not H2AK119ub in vitro."
27083998
sparser
"USP51 binds to H2A and deubiquitylates H2AK13,15ub in vitro."
27083998
USP51 affects PD‐L1
| 5
USP51 binds PD‐L1. 5 / 5
| 5
sparser
"At the molecular level, USP51 directly bound and deubiquitinated PD‐L1 at lysine residues K280 and K281."
37386737
sparser
"These findings also supported our observation that disruption of USP51/PD‐L1‐deployed juxtacrine interaction with a USP51 inhibitor DHM showed a higher chemotherapeutic efficacy in NSCLC in vitro and in vivo, suggesting that chemo‐immunotherapy or a combined treatment of anti‐PD‐1/PD‐L1 with their specific inhibitors could potentially serve a therapeutic role in future anticancer therapies."
37386737
sparser
"We further validated the physical interactions of PD‐L1 with USP51 (Figure  xref ), UCHL1 (Supplementary Figure xref ), RNF31 (Supplementary Figure xref ), and TRIM21 (Supplementary Figure xref ) in PD‐L1‐overexpressing A549 cells."
37386737
sparser
"The results revealed that USP51 directly associated with PD‐L1 in A549 cells, which was further increased in A549 R cells (Figure  xref )."
37386737
sparser
"In addition, three deletion constructs of PD‐L1‐C were generated to demonstrate that the deletion variant PD‐L1‐C3, but not PD‐L1‐C1 and PD‐L1‐C2, was able to interact with USP51 (Figure  xref ), highlighting that the PD‐L1C‐terminal region (280‐290aa) is critical for the USP51‐PD‐L1 association."
37386737
USP51 activates Neoplasm Invasiveness. 4 / 4
| 1 3
reach
"USP51 depletion inhibited the invasion of mesenchymal-like breast cancer cells by downregulating ZEB1 protein and mesenchymal marker expression and promoting E-cadherin upregulation."
39196911
eidos
"Moreover , we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1 , which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma ."
35058607
reach
"According to wound healing ( Fig. 6 F–G) and transwell ( Fig. 6 H–I) assays, overexpression of USP51 considerably enhanced cell migration and invasion."
36603607
reach
"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."
35058607
USP51 bound to ZEB1 activates Neoplasm Invasiveness. 1 / 1
| 1
reach
"By contrast, ubiquitin-specific peptidase 51 (USP51) binds to ZEB1 and promotes its ubiquitination and stability, thus supporting invasion by breast cancer cells [ 96 ]."
37328395
USP22 affects USP51
1 | 2 2
USP22 binds USP51.
1 | 2
USP22 binds USP51. 2 / 2
1 | 1
biogrid
No evidence text available
24981860
sparser
"To test this idea, we expressed wild type (WT) or mutant forms of USP22, USP27X and USP51 in which a conserved cysteine required for activity in USP22 is changed to serine in 293T cells ( xref )."
27132940
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP22 inhibits USP51.
| 1
USP22 inhibits USP51. 1 / 1
| 1
reach
"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5 associated proteins after shRNA mediated depletion of USP22 (XREF_FIG, lanes 2 and 3 and 5 and 6)."
27132940
USP22 activates USP51.
| 1
USP22 activates USP51. 1 / 1
| 1
reach
"Equal numbers of cells expressing shRNAs that specifically target USP27X or USP51, but not USP22 (XREF_FIG), or expressing control shRNA, were seeded and monitored for proliferation by cell counts 72 hours later."
27132940
PD‐L1 affects USP51
| 5
USP51 binds PD‐L1. 5 / 5
| 5
sparser
"At the molecular level, USP51 directly bound and deubiquitinated PD‐L1 at lysine residues K280 and K281."
37386737
sparser
"These findings also supported our observation that disruption of USP51/PD‐L1‐deployed juxtacrine interaction with a USP51 inhibitor DHM showed a higher chemotherapeutic efficacy in NSCLC in vitro and in vivo, suggesting that chemo‐immunotherapy or a combined treatment of anti‐PD‐1/PD‐L1 with their specific inhibitors could potentially serve a therapeutic role in future anticancer therapies."
37386737
sparser
"We further validated the physical interactions of PD‐L1 with USP51 (Figure  xref ), UCHL1 (Supplementary Figure xref ), RNF31 (Supplementary Figure xref ), and TRIM21 (Supplementary Figure xref ) in PD‐L1‐overexpressing A549 cells."
37386737
sparser
"The results revealed that USP51 directly associated with PD‐L1 in A549 cells, which was further increased in A549 R cells (Figure  xref )."
37386737
sparser
"In addition, three deletion constructs of PD‐L1‐C were generated to demonstrate that the deletion variant PD‐L1‐C3, but not PD‐L1‐C1 and PD‐L1‐C2, was able to interact with USP51 (Figure  xref ), highlighting that the PD‐L1C‐terminal region (280‐290aa) is critical for the USP51‐PD‐L1 association."
37386737
FAT4 affects USP51
2 | 2 1
FAT4 binds USP51. 5 / 5
2 | 2 1
biogrid
No evidence text available
31217854
biogrid
No evidence text available
31217854
reach
"FAT4 and USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway."
31217854
sparser
"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4's function in EC."
31217854
reach
"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4 's function in EC."
31217854
CDK4 affects USP51
3 | 2
CDK4 binds USP51.
3 |
USP51 binds CDK4. 3 / 3
3 |
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
CDK4 activates USP51.
| 2
CDK4 activates USP51. 2 / 2
| 2
eidos
"At the molecular level , CDK4 / 6 phosphorylates and activates USP51 , which is then responsible for the deubiquitination and stabilization of ZEB1 ."
32195004
eidos
"The phosphorylation and activation of USP51 by CDK4 / 6 is necessary to deubiquitinate and stabilize ZEB1 ."
32195004
USP51 affects HIF1A
2 | 2
USP51 deubiquitinates HIF1A.
| 2
USP51 deubiquitinates HIF1A. 2 / 2
| 2
reach
"USP51 efficiently deubiquitinates HIF1A and activates hypoxia-induced gene transcription."
37816999
reach
"SUMO-specific protease 1 (SENP1) mediates the deSUMOylation of ELOC, promoting the binding of USP51 to ELOC and facilitating the deubiquitination and stabilization of HIF1A by USP51."
37816999
USP51 binds HIF1A.
2 |
USP51 binds HIF1A. 2 / 2
2 |
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999
USP51 affects H2AK13,15ub
| 4
USP51 deubiquitinates H2AK13,15ub. 4 / 4
| 4
reach
"Here we show that USP51, a previously uncharacterized DUB, deubiquitylates H2AK13,15 ub and regulates DNA damage response."
27083998
reach
"USP51 deubiquitylates H2AK13,15 ub and regulates DNA damage response."
31164001
reach
"USP51 deubiquitylates H2AK13,15 ub and regulates DNA damage response."
27083998
reach
"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15 ub."
27083998
HIF1A affects USP51
2 | 2
HIF1A increases the amount of USP51.
| 2
HIF1A increases the amount of USP51. 2 / 2
| 2
reach
"Conversely, the activation of HIF1A under hypoxia transcriptionally upregulates the expression of USP51."
37816999
reach
"HIF1A upregulates USP51 expression under hypoxic conditions, while USP51 stabilizes HIF1A via deubiquitination, thereby maintaining its activity and supporting the proliferative and migratory capacities of tumor cells."
39995416
HIF1A binds USP51.
2 |
USP51 binds HIF1A. 2 / 2
2 |
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999
HDAC1 affects USP51
| 1 2 1
HDAC1 inhibits USP51. 4 / 4
| 1 2 1
eidos
"USP51 , which is only modestly inhibited by hD1 at very high concentrations , is 70 % identical in sequence to USP22 ."
34936860
sparser
"USP51, which is only modestly inhibited by hD1 at very high concentrations, is 70% identical in sequence to USP22."
34936860
reach
"USP51, which is only modestly inhibited by hD1 at very high concentrations, is 70% identical in sequence to USP22."
34936860
reach
"As shown in Figure 5B, hD1 inhibits the USP27x complex at >25-fold higher inhibitor concentrations and modestly inhibits the USP51 complex only at >2500-fold higher concentration than that needed to inhibit the human DUB module."
34936860
CDK6 affects USP51
3 | 1
CDK6 binds USP51.
3 |
USP51 binds CDK6. 3 / 3
3 |
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
CDK6 phosphorylates USP51.
| 1
CDK6 leads to the phosphorylation of USP51. 1 / 1
| 1
reach
"Over-expression of CDK6 causes the hyperphosphorylation of USP51 protein, causing its structural alteration and functional inactivation, and hence, USP51 protein cannot interact with ZEB1 protein [105[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35878668
Valproic acid affects USP51
3 |
Valproic acid decreases the amount of USP51. 3 / 3
3 |
ctd
No evidence text available
28001369
ctd
No evidence text available
27188386
ctd
No evidence text available
23179753
Hsa-miR-5011-5p affects USP51
3 |
Hsa-miR-5011-5p decreases the amount of USP51. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4798-3p affects USP51
3 |
Hsa-miR-4798-3p decreases the amount of USP51. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-377-3p affects USP51
3 |
Hsa-miR-377-3p decreases the amount of USP51. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-3680-5p affects USP51
3 |
Hsa-miR-3680-5p decreases the amount of USP51. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-342-3p affects USP51
3 |
Hsa-miR-342-3p decreases the amount of USP51. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-190a-3p affects USP51
3 |
Hsa-miR-190a-3p decreases the amount of USP51. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-1277-5p affects USP51
3 |
Hsa-miR-1277-5p decreases the amount of USP51. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
23313552
biopax:mirtarbase
No evidence text available
21572407
USP51 affects USP22
1 | 2
USP22 binds USP51. 2 / 2
1 | 1
biogrid
No evidence text available
24981860
sparser
"To test this idea, we expressed wild type (WT) or mutant forms of USP22, USP27X and USP51 in which a conserved cysteine required for activity in USP22 is changed to serine in 293T cells ( xref )."
27132940
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP51 affects TP53BP1
| 2
USP51 inhibits TP53BP1.
| 1
USP51 inhibits TP53BP1. 1 / 2
| 1
reach
"Overexpression of USP51 suppressed IR-induced foci formation of both 53BP1 and BRCA1 (Wang et al., 2016)."
35757003
USP51 deubiquitinates TP53BP1.
| 1
USP51 leads to the deubiquitination of TP53BP1. 1 / 1
| 1
reach
"Overexpression of USP51 suppresses H2A ubiquitination as well as 53BP1 and BRCA1, but not RNF168 IRIF formation."
33797206
USP51 affects TIMM8A
| 3
USP51 activates TIMM8A.
| 2
USP51 activates TIMM8A. 2 / 2
| 2
reach
"Collectively, the present findings demonstrated that USP51 inhibition attenuated DDP resistance in A549 and DDP cells via ubiquitin mediated degradation of ZEB1."
32468048
reach
"The cell viability (Supplementary Figure S20C), colony formation (Supplementary Figure S20D), cell apoptosis (Supplementary Figure S20E‐F), and DNA damage detection assays (Supplementary Figure S20G‐H) further confirmed that overexpression of USP51 strongly reduced cell proliferation retardation and cell apoptosis but promoted DNA damage repair in response to DDP; however, USP51‐induced chemoresistant phenotypes were weakened by the addition of DHM."
37386737
USP51 inhibits TIMM8A.
| 1
USP51 inhibits TIMM8A. 1 / 1
| 1
reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
35454770
USP51 affects PARP1
1 | 2
USP51 inhibits PARP1.
| 1
USP51 inhibits PARP1. 1 / 1
| 1
reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
35454770
USP51 binds PARP1.
1 |
USP51 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 activates PARP1.
| 1
USP51 activates PARP1. 1 / 1
| 1
reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
35454770
USP51 affects Neoplasm Metastasis
| 2 1
USP51 activates Neoplasm Metastasis. 3 / 3
| 2 1
eidos
"Moreover , we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1 , which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma ."
35058607
reach
"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."
35058607
eidos
"We found that the knockdown of USP51 resulted in significantly decreased lung metastasis ; however , this effect was attenuated in mice carrying ZEB1-expressing tumors ( Fig. 3e , f ) , confirming that the knockdown of USP51 reduces cancer metastasis through the regulation of ZEB1 in vivo ."
32195004
USP51 affects Histone_H2B
| 3
USP51 deubiquitinates Histone_H2B. 3 / 3
| 3
reach
"Remarkably, this inhibitor also showed greater activity on USP22 than on two other DUBs, USP27x and USP51, that also deubiquitinate histone H2B and form complexes with two of the SAGA DUB module adaptor subunits."
34936860
reach
"ATXN7L3 is a limiting factor for the activity of distinct complexes that contain USP22 (SAGA), USP27X, or USP51, which mediate Histone H2B deubiquitylation on different target genes."
38182161
reach
"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that all three use the ATXN7L3 zinc finger to dock the H2A and H2B acidic patch in a manner similar to that shown in the structure of the yeast DUB module bound to ubiquitinated nucleosomes."
27923209
USP51 affects CDK6
3 |
USP51 binds CDK6. 3 / 3
3 |
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
USP51 affects CDK4
3 |
USP51 binds CDK4. 3 / 3
3 |
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
biogrid
No evidence text available
32296027
USP51 affects CD274
3 |
CD274 binds USP51. 3 / 3
3 |
biogrid
No evidence text available
37386737
biogrid
No evidence text available
37386737
biogrid
No evidence text available
37386737
USP51 affects BRCA1
| 2
USP51 inhibits BRCA1.
| 1
USP51 inhibits BRCA1. 1 / 2
| 1
reach
"Overexpression of USP51 suppressed IR-induced foci formation of both 53BP1 and BRCA1 (Wang et al., 2016)."
35757003
USP51 deubiquitinates BRCA1.
| 1
USP51 leads to the deubiquitination of BRCA1. 1 / 1
| 1
reach
"Overexpression of USP51 suppresses H2A ubiquitination as well as 53BP1 and BRCA1, but not RNF168 IRIF formation."
33797206
ENY2 affects ATXN7L3
| 3
ATXN7L3 binds ENY2 and USP51. 2 / 2
| 2
sparser
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
sparser
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
CD274 affects USP51
3 |
CD274 binds USP51. 3 / 3
3 |
biogrid
No evidence text available
37386737
biogrid
No evidence text available
37386737
biogrid
No evidence text available
37386737
ATXN7L3 affects ENY2
| 3
ATXN7L3 binds ENY2 and USP51. 2 / 2
| 2
sparser
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
sparser
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."
27132940
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
6-propyl-2-thiouracil increases the amount of USP51.
2 |
6-propyl-2-thiouracil increases the amount of USP51. 2 / 2
2 |
ctd
No evidence text available
25825206
ctd
No evidence text available
24780913
6-propyl-2-thiouracil decreases the amount of USP51.
1 |
6-propyl-2-thiouracil decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
30047161
Titanium dioxide affects USP51
2 |
Titanium dioxide demethylates USP51.
1 |
Titanium dioxide demethylates USP51. 1 / 1
1 |
ctd
No evidence text available
35295148
Titanium dioxide decreases the amount of USP51.
1 |
Titanium dioxide decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
29264374
Sodium arsenite affects USP51
2 |
Sodium arsenite increases the amount of USP51.
1 |
Sodium arsenite increases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
29301061
Sodium arsenite decreases the amount of USP51.
1 |
Sodium arsenite decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
37682722
Nickel atom affects USP51
2 |
Nickel atom decreases the amount of USP51. 2 / 2
2 |
ctd
No evidence text available
24768652
ctd
No evidence text available
25583101
Hsa-miR-362-3p affects USP51
2 |
Hsa-miR-362-3p decreases the amount of USP51. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-329-3p affects USP51
2 |
Hsa-miR-329-3p decreases the amount of USP51. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Furan affects USP51
2 |
Furan methylates USP51.
1 |
Furan methylates USP51. 1 / 1
1 |
ctd
No evidence text available
22079235
Furan decreases the amount of USP51.
1 |
Furan decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
26194646
End3 affects USP51
| 2
USP51 binds end3. 2 / 2
| 2
sparser
"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5-associated proteins after shRNA-mediated depletion of USP22 ( xref , lanes 2 and 3 and 5 and 6)."
27132940
sparser
"USP27X and USP51 Do Not Associate with SAGA."
27132940
VHL affects USP51
1 | 1
USP51 binds VHL. 2 / 2
1 | 1
sparser
"USP51 associates with VHL through the Elongin C subunit and counteracts HIF-1α ubiquitination [ xref ]."
39584532
biogrid
No evidence text available
37816999
USP51 affects end3
| 2
USP51 binds end3. 2 / 2
| 2
sparser
"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5-associated proteins after shRNA-mediated depletion of USP22 ( xref , lanes 2 and 3 and 5 and 6)."
27132940
sparser
"USP27X and USP51 Do Not Associate with SAGA."
27132940
reach
"In conclusion, suppression of FAT4 by inactivation of deubiquitinating enzyme USP51 promoted proliferation and invasion of EC cells via inhibiting Hippo pathway."
31217854
reach
"Knockdown of USP51 decreases the cell proliferation and halts the cell cycle at G0/G1 phase."
32486158
USP51 affects cdk-4
| 2
USP51 binds cdk-4. 2 / 2
| 2
sparser
"CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB1."
35058607
sparser
"However, the relationship between CDK4/6-USP51 and ZEB1 remains unclear."
40877392
USP51 affects apoptotic process
| 2
reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
35454770
reach
"The cell viability (Supplementary Figure S20C), colony formation (Supplementary Figure S20D), cell apoptosis (Supplementary Figure S20E‐F), and DNA damage detection assays (Supplementary Figure S20G‐H) further confirmed that overexpression of USP51 strongly reduced cell proliferation retardation and cell apoptosis but promoted DNA damage repair in response to DDP; however, USP51‐induced chemoresistant phenotypes were weakened by the addition of DHM."
37386737
USP51 affects VHL
1 | 1
USP51 binds VHL. 2 / 2
1 | 1
sparser
"USP51 associates with VHL through the Elongin C subunit and counteracts HIF-1α ubiquitination [ xref ]."
39584532
biogrid
No evidence text available
37816999
USP51 affects USP17L2
| 2
USP51 binds USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
CDK binds USP51 and USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
USP51 affects USP
| 1 1
USP51 inhibits USP.
| 1
USP51 inhibits USP. 1 / 1
| 1
reach
"These analyses revealed a substantial overlap of altered genes between the depletion of each of the three USPs, including 340 commonly affected genes (p-value 1.1e-130 by Fisher 's exact test) in USP27X and USP51 depleted cells, 283 (p-value 3.3e-34) commonly affected genes in USP22 and USP27X depleted cells, 249 commonly affected genes (p-value 1.1e-74) in USP22 and USP51 depleted cells, and 137 commonly altered genes in all three USP depletions (~ 10% of all altered genes) (XREF_FIG)."
27132940
USP51 binds USP.
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP51 affects SOX2
| 2
USP51 increases the amount of SOX2.
| 1
USP51 increases the amount of SOX2. 1 / 1
| 1
reach
"Knockdown of USP51 decreased the expression of CD44, NANOG, SOX2, OCT4, C-MYC, and EPCAM."
37422632
USP51 activates SOX2.
| 1
USP51 activates SOX2. 1 / 1
| 1
reach
"Ectopic TWIST1 expression restored the expression of stemness markers CD44, NANOG, SOX2, OCT4, and C-MYC, that was attenuated by USP51 depletion (Fig. 6A–C)."
37422632
USP51 affects SH3KBP1
2 |
USP51 binds SH3KBP1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
27132940
USP51 affects PRMT2
2 |
PRMT2 binds USP51. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
33961781
USP51 affects POU5F1
| 2
USP51 increases the amount of POU5F1.
| 1
USP51 increases the amount of POU5F1. 1 / 1
| 1
reach
"Knockdown of USP51 decreased the expression of CD44, NANOG, SOX2, OCT4, C-MYC, and EPCAM."
37422632
USP51 activates POU5F1.
| 1
USP51 activates POU5F1. 1 / 1
| 1
reach
"Ectopic TWIST1 expression restored the expression of stemness markers CD44, NANOG, SOX2, OCT4, and C-MYC, that was attenuated by USP51 depletion (Fig. 6A–C)."
37422632
USP51 affects NEK8
| 2
USP51 binds NEK8. 2 / 2
| 2
sparser
"Co-immunoprecipitation, co-immunofluorescence, ubiquitination assays, and functional rescue experiments proved that USP51 directly interacted with NEK8 and lowered the ubiquitination level of NEK8."
41475333
sparser
"Taken together, our study reveals that the USP51-NEK8 axis promotes progression of CRC via the β-catenin pathway and could be a potential target for the treatment of CRC."
41475333
USP51 affects Mice
| 2
USP51 inhibits Mice.
| 1
USP51 inhibits Mice. 1 / 1
| 1
reach
"Absence of USP51 expression reduces the tumorigenic ability of NSCLC cells in mice."
37422632
USP51 activates Mice.
| 1
USP51 activates Mice. 1 / 1
| 1
reach
"In summary, USP51 enhances the tumorigenic ability of NSCLC cells in mice by stabilizing TWIST1."
37422632
USP51 affects MYC
| 2
USP51 increases the amount of MYC.
| 1
USP51 increases the amount of MYC. 1 / 1
| 1
reach
"Knockdown of USP51 decreased the expression of CD44, NANOG, SOX2, OCT4, C-MYC, and EPCAM."
37422632
USP51 activates MYC.
| 1
USP51 activates MYC. 1 / 1
| 1
reach
"Ectopic TWIST1 expression restored the expression of stemness markers CD44, NANOG, SOX2, OCT4, and C-MYC, that was attenuated by USP51 depletion (Fig. 6A–C)."
37422632
USP51 affects MRC1
| 2
USP51 binds MRC1. 2 / 2
| 2
sparser
"USP51 was found to be correlated with the M2 phenotype of TAMs in the microarray data ( Fig. 9 J, mGEO, r = 0.127, P < 0.001), which was further validated in TCGA-STAD ( Fig. 9 K; MRC1-USP51, r = 0.34[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
sparser
"As shown in Fig. 9 L-M, there was a strong positive correlation between the expression of CD163, CD206, and USP51 (CD206-USP51, r = 0.481, P = 0.002; CD163-USP51, r = 0.547, P < 0.001)."
36603607
USP51 affects H2BC3
2 |
USP51 binds H2BC3. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
30192049
USP51 affects H2AC8
2 |
USP51 binds H2AC8. 2 / 2
2 |
biogrid
No evidence text available
30192049
biogrid
No evidence text available
27132940
USP51 affects ELOB
2 |
USP51 binds ELOB. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
37816999
reach
"The role of USP51 in attenuating chemosensitivity of lung cancer cells to cisplatin by regulating DNA damage response."
35856403
reach
"USP51 depletion results in increased spontaneous DNA damage foci and elevated levels of H2AK15ub and impairs DNA damage response."
27083998
USP51 affects CTNNB1
| 1 1
USP51 binds CTNNB1. 2 / 2
| 1 1
reach
"USP51 interacts with beta-catenin and reduces ubiquitination of beta-catenin."
32486158
sparser
"USP51 interacts with β-catenin and reduces ubiquitination of β-catenin."
32486158
USP51 affects CHEK1
| 2
USP51 leads to the phosphorylation of CHEK1. 2 / 2
| 2
reach
"USP51 overexpression in lung cancer cells in vitro reduced γ-H2AX formation and promoted CHK1 phosphorylation, whereas USP51 knockdown showed opposite effects, indicating that USP51 played an important role in promoting DNA damage repair."
35856403
reach
"In lung cancer patients with cisplatin resistance, the upregulation of USP51 diminishes γH2AX formation and increases checkpoint kinase 1 (CHK1) phosphorylation, thereby ensuring an effective cell cycle [29]."
38702734
USP51 affects CD163
| 2
USP51 binds CD163. 2 / 2
| 2
sparser
"USP51 was found to be correlated with the M2 phenotype of TAMs in the microarray data ( Fig. 9 J, mGEO, r = 0.127, P < 0.001), which was further validated in TCGA-STAD ( Fig. 9 K; MRC1-USP51, r = 0.34[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
sparser
"As shown in Fig. 9 L-M, there was a strong positive correlation between the expression of CD163, CD206, and USP51 (CD206-USP51, r = 0.481, P = 0.002; CD163-USP51, r = 0.547, P < 0.001)."
36603607
USP51 affects CASP3
| 2
USP51 inhibits CASP3.
| 1
USP51 inhibits CASP3. 1 / 1
| 1
reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
35454770
USP51 activates CASP3.
| 1
USP51 activates CASP3. 1 / 1
| 1
reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
35454770
USP51 affects C1QBP
2 |
USP51 binds C1QBP. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
27132940
USP17L2 affects USP51
| 2
USP51 binds USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
CDK binds USP51 and USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
SH3KBP1 affects USP51
2 |
USP51 binds SH3KBP1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
27132940
Parkinson Disease affects USP51
| 2
USP51 binds Parkinson Disease and A549. 1 / 1
| 1
reach
"The results revealed that USP51 directly associated with PD‐L1 in A549 cells, which was further increased in A549 cells (Figure 5A)."
37386737
USP51 binds Parkinson Disease and lysine residues K280. 1 / 1
| 1
reach
"At the molecular level, USP51 directly bound and deubiquitinated PD‐L1 at lysine residues K280 and K281."
37386737
PRMT2 affects USP51
2 |
PRMT2 binds USP51. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
33961781
NEK8 affects USP51
| 2
USP51 binds NEK8. 2 / 2
| 2
sparser
"Co-immunoprecipitation, co-immunofluorescence, ubiquitination assays, and functional rescue experiments proved that USP51 directly interacted with NEK8 and lowered the ubiquitination level of NEK8."
41475333
sparser
"Taken together, our study reveals that the USP51-NEK8 axis promotes progression of CRC via the β-catenin pathway and could be a potential target for the treatment of CRC."
41475333
MRC1 affects USP51
| 2
USP51 binds MRC1. 2 / 2
| 2
sparser
"USP51 was found to be correlated with the M2 phenotype of TAMs in the microarray data ( Fig. 9 J, mGEO, r = 0.127, P < 0.001), which was further validated in TCGA-STAD ( Fig. 9 K; MRC1-USP51, r = 0.34[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
sparser
"As shown in Fig. 9 L-M, there was a strong positive correlation between the expression of CD163, CD206, and USP51 (CD206-USP51, r = 0.481, P = 0.002; CD163-USP51, r = 0.547, P < 0.001)."
36603607
H2BC3 affects USP51
2 |
USP51 binds H2BC3. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
30192049
H2AC8 affects USP51
2 |
USP51 binds H2AC8. 2 / 2
2 |
biogrid
No evidence text available
30192049
biogrid
No evidence text available
27132940
ELOB affects USP51
2 |
USP51 binds ELOB. 2 / 2
2 |
biogrid
No evidence text available
27132940
biogrid
No evidence text available
37816999
DHM affects USP51
| 2
DHM inhibits USP51.
| 1
DHM inhibits USP51. 1 / 1
| 1
reach
"Five compounds, dihydromyricetin (DHM), (‐)‐epigallocatechin (EGC), gallic acid, linoleic acid, and tannic acid, were shown to significantly inhibit the deubiquitinase activity of USP51 at a concentration of 1 μmol/L (Supplementary Table S4)."
37386737
DHM binds USP51.
| 1
USP51 binds DHM. 1 / 1
| 1
reach
"In line with this, the SPR binding assay validated a significantly increased binding affinity between USP51 and DHM (Figure 7D)."
37386737
CTNNB1 affects USP51
| 1 1
USP51 binds CTNNB1. 2 / 2
| 1 1
reach
"USP51 interacts with beta-catenin and reduces ubiquitination of beta-catenin."
32486158
sparser
"USP51 interacts with β-catenin and reduces ubiquitination of β-catenin."
32486158
CDK affects USP51
| 2
CDK phosphorylates USP51.
| 1
CDK phosphorylates USP51. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
CDK binds USP51.
| 1
CDK binds USP51 and USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
CD163 affects USP51
| 2
USP51 binds CD163. 2 / 2
| 2
sparser
"USP51 was found to be correlated with the M2 phenotype of TAMs in the microarray data ( Fig. 9 J, mGEO, r = 0.127, P < 0.001), which was further validated in TCGA-STAD ( Fig. 9 K; MRC1-USP51, r = 0.34[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
sparser
"As shown in Fig. 9 L-M, there was a strong positive correlation between the expression of CD163, CD206, and USP51 (CD206-USP51, r = 0.481, P = 0.002; CD163-USP51, r = 0.547, P < 0.001)."
36603607
C1QBP affects USP51
2 |
USP51 binds C1QBP. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
27132940
ATXN7L3 affects ENY2, and USP51
| 2
ATXN7L3 binds ENY2 and USP51. 2 / 2
| 2
sparser
"ATXN7L3 and ENY2 associate with USP27X and USP51."
27132940
sparser
"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."
27132940
Triptonide affects USP51
1 |
Triptonide increases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
33045310
Trichloroethene affects USP51
1 |
Trichloroethene decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
33387578
Treatment palbociclib Lee011 affects USP51
| 1
Treatment palbociclib Lee011 inhibits USP51. 1 / 1
| 1
eidos
"Instead , treatment with palbociclib and Lee011 induced the inactivation of USP51 , the destabilization of ZEB1 protein and a decrease in cell migration , thereby reducing the degree of TNBC metastasis both in vitro and in vivo ."
32195004
Thimerosal affects USP51
1 |
Thimerosal decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
27188386
Terbufos affects USP51
1 |
Terbufos methylates USP51. 1 / 1
1 |
ctd
No evidence text available
22847954
Sunitinib affects USP51
1 |
Sunitinib increases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
31533062
Sulfadimethoxine affects USP51
1 |
Sulfadimethoxine decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
30047161
Silver(0) affects USP51
1 |
Silver(0) decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
27131904
Parathion affects USP51
1 |
Parathion methylates USP51. 1 / 1
1 |
ctd
No evidence text available
22847954
Methylmercury chloride decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
28001369
Methyl methanesulfonate increases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
23649840
Methimazole affects USP51
1 |
Methimazole decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
30047161
Lysine residues K280 affects USP51
| 1
USP51 binds Parkinson Disease and lysine residues K280. 1 / 1
| 1
reach
"At the molecular level, USP51 directly bound and deubiquitinated PD‐L1 at lysine residues K280 and K281."
37386737
Iron dichloride affects USP51
1 |
Iron dichloride decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
35984750
Hydroquinone affects USP51
1 |
Hydroquinone decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
31256213
Hsa-mir-4719 affects USP51
1 |
Hsa-mir-4719 decreases the amount of USP51. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-mir-4705 affects USP51
1 |
Hsa-mir-4705 decreases the amount of USP51. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-mir-3163 affects USP51
1 |
Hsa-mir-3163 decreases the amount of USP51. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-95-5p affects USP51
1 |
Hsa-miR-95-5p decreases the amount of USP51. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4668-3p affects USP51
1 |
Hsa-miR-4668-3p decreases the amount of USP51. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-338-5p affects USP51
1 |
Hsa-miR-338-5p decreases the amount of USP51. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-187-5p affects USP51
1 |
Hsa-miR-187-5p decreases the amount of USP51. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Fonofos affects USP51
1 |
Fonofos methylates USP51. 1 / 1
1 |
ctd
No evidence text available
22847954
Dihydromyricetin affects USP51
| 1
reach
"Five compounds, dihydromyricetin (DHM), (‐)‐epigallocatechin (EGC), gallic acid, linoleic acid, and tannic acid, were shown to significantly inhibit the deubiquitinase activity of USP51 at a concentration of 1 μmol/L (Supplementary Table S4)."
37386737
Bisphenol A affects USP51
1 |
Bisphenol A decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
25181051
Benzo[a]pyrene affects USP51
1 |
Benzo[a]pyrene demethylates USP51. 1 / 1
1 |
ctd
No evidence text available
27901495
Atrazine affects USP51
1 |
Atrazine increases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
22378314
Amitrole affects USP51
1 |
Amitrole decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
30047161
Abrine affects USP51
1 |
Abrine decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
31054353
ZIC1 affects USP51
1 |
ZIC1 decreases the amount of USP51. 1 / 1
1 |
biopax:msigdb
No evidence text available
ZEB affects USP51
| 1
USP51 binds ZEB. 1 / 1
| 1
reach
"Notably, overexpression of ZEB1 in A549 and DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."
32468048
VAMP3 affects USP51
1 |
VAMP3 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
38334954
VAMP2 affects USP51
1 |
VAMP2 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
38334954
VAMP1 affects USP51
1 |
VAMP1 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
38334954
USP51 affects vimentin MDA-MB-231 SUM-159 cells
| 1
USP51 activates vimentin MDA-MB-231 SUM-159 cells. 1 / 1
| 1
eidos
"Western blotting showed that the downregulation of USP51 resulted in increased E-cadherin expression but decreased vimentin and N-cadherin expression in MDA-MB-231 and SUM-159 cells ( Fig. 3a ) ."
32195004
USP51 affects ubiquitination WT DGCR8 S677D mutant
| 1
USP51 inhibits ubiquitination WT DGCR8 S677D mutant. 1 / 1
| 1
eidos
"Moreover , USP51 markedly reduced the ubiquitination of either WT DGCR8 or the S677D mutant , but had little effect on the ubiquitination of the S677A mutant ( Fig. 8c) ."
34188037
USP51 affects tumor growth
| 1
USP51 activates tumor growth. 1 / 1
| 1
eidos
"Finally , USP51 knockdown weakened cisplatin resistance in A549 / DDP cells and significantly suppressed tumor growth in vivo , suggesting that a USP51 inhibitor combined with cisplatin may be considered as an effective treatment strategy to eliminate drug-resistant lung cancer cells ."
35856403
USP51 affects recruitment RNF168 53BP1 BRCA1 DSBs
| 1
USP51 activates recruitment RNF168 53BP1 BRCA1 DSBs. 1 / 1
| 1
eidos
"Similar to the DGCR8-knockdown effects ( Fig. 3a , b , f ) , knockdown of USP51 not only decreased HR and NHEJ repair efficiency in LM2-DRR cells ( Fig. 5e and Supplementary Fig. 5c , d ) , but also abrogated the recruitment of RNF168 , 53BP1 , and BRCA1 to DSBs after radiation treatment , without affecting the recruitment of MDC1 and RNF8 ( Fig. 5f and Supplementary Fig. 6 ) ."
34188037
reach
"Unsupervised heatmap clustering revealed cluster 12 and 14 to have close homology in terms of the high expression of USP51 and CASP8AP2 which are both known to promote ZEB1 protein stabilization [30, 31] (Supplementary Fig. 3B)."
38191418
USP51 inhibits protein polyubiquitination. 1 / 1
| 1
reach
"Based on our ubiquitination assay, USP51 depletion strongly enhanced PD‐L1 protein polyubiquitination in A549 cells (Figure 4F), collectively suggesting that USP51, a deubiquitinase, targeted PD‐L1 protein for deubiquitination and stabilization."
37386737
USP51 affects polyubiquitination ZEB1 protein
| 1
USP51 inhibits polyubiquitination ZEB1 protein. 1 / 1
| 1
eidos
"Taken together with the results of the ubiquitination assay showing that USP51 knockdown led to increased polyubiquitination of the ZEB1 protein upon MG132 treatment ( Fig. 2i ) , the above observations collectively suggested that USP51 is a bona fide DUB that targets the ZEB1 protein for deubiquitination and stabilization ."
32195004
USP51 affects poly-ubiquitination H2A induced RNF8 RNF168
| 1
USP51 activates poly-ubiquitination H2A induced RNF8 RNF168. 1 / 1
| 1
eidos
"Moreover , the mono - , di - , and poly-ubiquitination of H2A induced by RNF8 and RNF168 upon IR was abolished by USP51 knockdown ( Fig. 5g ) ."
34188037
USP51 affects messenger RNA
| 1
USP51 activates messenger RNA. 1 / 1
| 1
eidos
"USP51 depletion attenuated mRNA , protein , and cell surface expression of stemness markers and the stemness of NSCLC cells ."
37422632
USP51 affects mesenchymal markers
| 1
USP51 activates mesenchymal markers. 1 / 1
| 1
eidos
"Thus , the deubiquitinases ( DUBs ) were involved in counteracting polyubiquitination and proteasomal degradation of ZEB1 [ 40 ] ; these DUBs include USP51 , which upregulated ZEB1 and the mesenchymal markers by binding , deubiquitinating , and stabilizing ZEB1 [ 41 ] ."
32014049
USP51 affects mesenchymal markers including vimentin
| 1
USP51 activates mesenchymal markers including vimentin. 1 / 1
| 1
eidos
"Consequently , USP51 upregulates the mesenchymal markers including N-cadherin and vimentin [ 171 ] ."
33808323
USP51 affects lysine residues K280
| 1
USP51 binds Parkinson Disease and lysine residues K280. 1 / 1
| 1
reach
"At the molecular level, USP51 directly bound and deubiquitinated PD‐L1 at lysine residues K280 and K281."
37386737
USP51 affects lung metastasis
| 1
USP51 activates lung metastasis. 1 / 1
| 1
eidos
"We found that the knockdown of USP51 resulted in significantly decreased lung metastasis ; however , this effect was attenuated in mice carrying ZEB1-expressing tumors ( Fig. 3e , f ) , confirming that the knockdown of USP51 reduces cancer metastasis through the regulation of ZEB1 in vivo ."
32195004
USP51 affects hypersensitivity
| 1
USP51 inhibits hypersensitivity. 1 / 1
| 1
reach
"USP51 depletion leads to ionizing radiation hypersensitivity and dysregulated DNA repair [78]."
33797206
USP51 affects hispidulin TRAIL cells
| 1
USP51 activates hispidulin TRAIL cells. 1 / 1
| 1
eidos
"Inhibition of USP51 partially blocked apoptosis by hispidulin plus TRAIL in Caki , A498 and DU145 cells ( Figure 6F ) ."
31817696
USP51 activates epithelial to mesenchymal transition. 1 / 1
| 1
reach
"Collectively, these findings demonstrate that the inhibition of mTOR or USP51 attenuates the EMT phenotype through the ubiquitin-mediated degradation of ZEB1."
35454770
USP51 affects deubiquitination stabilization ZEB1.33
| 1
USP51 activates deubiquitination stabilization ZEB1.33. 1 / 1
| 1
eidos
"USP51 deubiquitinates and stabilizes ZEB1 It was previously reported that USP51 , a deubiquitinase , could promote the deubiquitination and stabilization of ZEB1.33 Notably , we searched the PhosphoSitePlus ( R ) database and identified Ser26 as a major phosphorylation site on USP51 ( Supplementary Fig. S6a ) , which also matches the CDK consensus motif S / T-P ."
32195004
USP51 affects cisplatin
| 1
USP51 activates cisplatin. 1 / 1
| 1
reach
"Knockout of USP51 may reduce cisplatin resistance in LC cells through ubiquitination of ZEB1 (82)."
37795365
USP51 affects cell migration
| 1
USP51 activates cell migration. 1 / 1
| 1
reach
"According to wound healing ( Fig. 6 F–G) and transwell ( Fig. 6 H–I) assays, overexpression of USP51 considerably enhanced cell migration and invasion."
36603607
USP51 affects cell cycle
| 1
USP51 inhibits cell cycle. 1 / 1
| 1
reach
"Knockdown of USP51 decreases the cell proliferation and halts the cell cycle at G0/G1 phase."
32486158
USP51 affects cancer cell metastasis
| 1
USP51 activates cancer cell metastasis. 1 / 1
| 1
eidos
"USP51 regulates cancer metastasis through ZEB1 We next examined whether USP51 depletion could inhibit cancer cell metastasis through the regulation of ZEB1 ."
32195004
USP51 affects ZEB1 protein
| 1
USP51 activates ZEB1 protein. 1 / 1
| 1
eidos
"Remarkably , USP51 depletion promoted ZEB1 protein degradation in response to treatment with CHX ( Fig. 2g ) ."
32195004
USP51 affects ZEB1 protein stability breast cancer cell lines
| 1
USP51 activates ZEB1 protein stability breast cancer cell lines. 1 / 1
| 1
eidos
"Among DUBs , ubiquitin specific peptidase 51 ( USP51 ) binds to the N-terminal of ZEB1 and increases ZEB1 protein stability in breast cancer cell lines [ 171 ] ."
33808323
USP51 affects ZEB
| 1
USP51 binds ZEB. 1 / 1
| 1
reach
"Notably, overexpression of ZEB1 in A549 and DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."
32468048
USP51 affects VIM
| 1
USP51 activates VIM. 1 / 1
| 1
reach
"In vitro , ectopic expression of USP51 up-regulates Zeb1 and the mesenchymal markers N-cadherin and Vimentin [ 77 ]."
30453041
USP51 affects VAMP3
1 |
VAMP3 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
38334954
USP51 affects VAMP2
1 |
VAMP2 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
38334954
USP51 affects VAMP1
1 |
VAMP1 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
38334954
USP51 affects Ubiquitin
| 1
USP51 inhibits Ubiquitin. 1 / 1
| 1
reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
35454770
USP51 affects USP28
1 |
USP28 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP51 affects USP21
1 |
USP21 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP51 affects USP15
1 |
USP15 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP51 affects U2AF2
1 |
USP51 binds U2AF2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects TRIM28
1 |
USP51 binds TRIM28. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects TARDBP
1 |
USP51 binds TARDBP. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects TAF9B
1 |
TAF9B binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects TAF6L
1 |
USP51 binds TAF6L. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects TAF5L
1 |
TAF5L binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects TADA3
1 |
TADA3 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects TADA2B
1 |
TADA2B binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects TADA1
1 |
TADA1 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects Stomach Neoplasms
| 1
USP51 activates Stomach Neoplasms. 1 / 1
| 1
reach
"Given the significance of USP51 as an upstream initiation factor, disruption of USP51 expression would considerably lower the mesenchymal phenotype of GC."
36603607
USP51 affects SUPT7L
1 |
SUPT7L binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects SUPT20H
1 |
SUPT20H binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects SPIN1
1 |
USP51 binds SPIN1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects SNRPD2
1 |
USP51 binds SNRPD2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects SNAI2
| 1
USP51 decreases the amount of SNAI2. 1 / 1
| 1
reach
"Furthermore, a significant correlation was observed between USP51 and EMT markers in the bulk transcriptome data ( Fig. 6 J, TCGA-STAD; Fig. 6 K, mGEO), and subsequent WB assay showed that in HGC-27 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
USP51 affects SNAI1
| 1
USP51 decreases the amount of SNAI1. 1 / 1
| 1
reach
"Furthermore, a significant correlation was observed between USP51 and EMT markers in the bulk transcriptome data ( Fig. 6 J, TCGA-STAD; Fig. 6 K, mGEO), and subsequent WB assay showed that in HGC-27 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
USP51 affects SLC25A5
1 |
USP51 binds SLC25A5. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects SGF29
1 |
SGF29 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects SESN2
| 1
USP51 increases the amount of SESN2. 1 / 1
| 1
reach
"USP51 efficiently deubiquitinates HIF1A and activates hypoxia-induced gene transcription."
37816999
USP51 activates Radiation, Ionizing. 1 / 1
| 1
reach
"Interestingly, USP51 overexpression also increases sensitivity to IR, suggesting DSB repair needs to be maintained in a delicate balance."
32708614
USP51 affects RUVBL1
1 |
USP51 binds RUVBL1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects RPS9
1 |
USP51 binds RPS9. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects RNF169
| 1
USP51 inhibits RNF169. 1 / 1
| 1
reach
"Conversely, USP51 overexpression does lead to reduced RNF169, 53BP1, and BRCA1 foci, all of which are recruited to RNF168 targets."
32708614
USP51 affects RBX1
1 |
USP51 binds RBX1. 1 / 1
1 |
biogrid
No evidence text available
37816999
USP51 affects RBM39
1 |
USP51 binds RBM39. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects RBFOX2
1 |
USP51 binds RBFOX2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects RBBP7
1 |
USP51 binds RBBP7. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects RBBP4
1 |
USP51 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects PJA1
1 |
PJA1 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP51 affects PCNA
1 |
USP51 binds PCNA. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects PCBP1
1 |
USP51 binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects NPM1
1 |
USP51 binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects NHEJ repair efficiency
| 1
USP51 activates NHEJ repair efficiency. 1 / 1
| 1
eidos
"Similar to the DGCR8-knockdown effects ( Fig. 3a , b , f ) , knockdown of USP51 not only decreased HR and NHEJ repair efficiency in LM2-DRR cells ( Fig. 5e and Supplementary Fig. 5c , d ) , but also abrogated the recruitment of RNF168 , 53BP1 , and BRCA1 to DSBs after radiation treatment , without affecting the recruitment of MDC1 and RNF8 ( Fig. 5f and Supplementary Fig. 6 ) ."
34188037
USP51 affects NHEJ efficiency LM2-DRR cells
| 1
USP51 activates NHEJ efficiency LM2-DRR cells. 1 / 1
| 1
eidos
"e Knockdown of USP51 decreased HR and NHEJ efficiency in LM2-DRR cells ."
34188037
USP51 affects NANOG
| 1
USP51 increases the amount of NANOG. 1 / 1
| 1
reach
"Knockdown of USP51 decreased the expression of CD44, NANOG, SOX2, OCT4, C-MYC, and EPCAM."
37422632
USP51 affects N-calmodulin
| 1
USP51 decreases the amount of N-calmodulin. 1 / 1
| 1
reach
"Furthermore, a significant correlation was observed between USP51 and EMT markers in the bulk transcriptome data ( Fig. 6 J, TCGA-STAD; Fig. 6 K, mGEO), and subsequent WB assay showed that in HGC-27 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
USP51 affects MMP9
| 1
USP51 decreases the amount of MMP9. 1 / 1
| 1
reach
"Furthermore, a significant correlation was observed between USP51 and EMT markers in the bulk transcriptome data ( Fig. 6 J, TCGA-STAD; Fig. 6 K, mGEO), and subsequent WB assay showed that in HGC-27 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
USP51 affects MMP2
| 1
USP51 decreases the amount of MMP2. 1 / 1
| 1
reach
"Furthermore, a significant correlation was observed between USP51 and EMT markers in the bulk transcriptome data ( Fig. 6 J, TCGA-STAD; Fig. 6 K, mGEO), and subsequent WB assay showed that in HGC-27 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
USP51 affects MGA
1 |
USP51 binds MGA. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects MDM2
1 |
USP51 binds MDM2. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP51 affects MATR3
1 |
USP51 binds MATR3. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects LUC7L3
1 |
USP51 binds LUC7L3. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects LBR
1 |
USP51 binds LBR. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP51 affects KAT2B
1 |
KAT2B binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects JMY
1 |
USP51 binds JMY. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP51 affects Histone
| 1
USP51 activates Histone. 1 / 1
| 1
reach
"Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones."
30192049
USP51 affects His2A
| 1
USP51 binds His2A. 1 / 1
| 1
reach
"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15 ub."
27083998
USP51 affects HSPA9
1 |
USP51 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects HSPA8
1 |
USP51 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects HSPA1A
1 |
USP51 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects HNRNPH2
1 |
USP51 binds HNRNPH2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects HNRNPF
1 |
USP51 binds HNRNPF. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects HES1
| 1
USP51 deubiquitinates HES1. 1 / 1
| 1
reach
"Another study demonstrated that USP27x, Usp22, and Usp51 deubiquitinate and stabilize Hes1 protein, a transcriptional repressor necessary for the maintenance of neural stem/progenitor cells."
38952059
USP51 affects H2Bub1
| 1
USP51 deubiquitinates H2Bub1. 1 / 1
| 1
reach
"USP22, USP27X, or USP51 require ATXN7L3 and ENY2 for their full activity and are unable to deubiquitinate H2Bub1 alone."
35806465
USP51 affects H2BK120Ub
| 1
USP51 deubiquitinates H2BK120Ub. 1 / 1
| 1
reach
"Further experiments established that USP51 in vitro could deubiquitinate a nucleosome carrying H2BK120Ub, but not H2BK34Ub."
30192049
USP51 affects H2BC10
1 |
USP51 deubiquitinates H2BC10. 1 / 1
1 |
ubibrowser
"In contrast, depletion of non-enzymatic components, ATXN7L3 or ENY2, results in increased <span class="match term1">H2Bub1</span>. These observations led us to discover two H2Bub1 DUBs, USP27X and <span class="match term0">USP51</span>, which function independently of SAGA and compete with USP22 for ATXN7L3 and ENY2 for activity."
27132940
USP51 affects H2Aub1
| 1
USP51 deubiquitinates H2Aub1. 1 / 1
| 1
reach
"As was previously shown for the USP22 DUBm, both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1 (XREF_FIG and XREF_SUPPLEMENTARY)."
27132940
USP51 affects H2AX
| 1
USP51 deubiquitinates H2AX. 1 / 1
| 1
reach
"USP3, USP51 and USP16 de-ubiquitinate H2A/H2AX with varying degrees of specificity [47–49]."
31769469
USP51 affects H2AK15ub
| 1
USP51 activates H2AK15ub. 1 / 1
| 1
reach
"USP51 directly interacts with the H2A-H2B dimer and modulates H2AK15ub accumulation, promoting the assembly of repair proteins during the initial phase of DNA damage [29]."
39996778
USP51 affects H2AK13/15
| 1
USP51 leads to the deubiquitination of H2AK13/15. 1 / 1
| 1
reach
"Depletion of USP51 also leads to an increase in 53BP1 foci formation, suggesting a role in deubiquitylating H2AK13/15 (Wang et al. 2016)."
31164001
USP51 affects H1-3
1 |
USP51 binds H1-3. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP51 affects GSTA1
1 |
USP51 binds GSTA1. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP51 affects FBL
1 |
USP51 binds FBL. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects EPCAM
| 1
USP51 increases the amount of EPCAM. 1 / 1
| 1
reach
"Knockdown of USP51 decreased the expression of CD44, NANOG, SOX2, OCT4, C-MYC, and EPCAM."
37422632
USP51 affects EIF4A1
1 |
USP51 binds EIF4A1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects EGFP
| 1
USP51 binds EGFP. 1 / 1
| 1
sparser
"In cells, H2A and its modified species could be coimmunoprecipitated with EGFP-USP51 ( xref B)."
27083998
USP51 affects E3_Ub_ligase
| 1
sparser
"Mechanically, USP51 directly binds to Elongin C (ELOC) and forms a larger functional complex with VHL E3 ligase (USP51/VHL/CUL2/ELOB/ELOC/RBX1) to regulate the ubiquitin-dependent proteasomal degradation of HIF1A."
37816999
USP51 affects DNAJA2
1 |
USP51 binds DNAJA2. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects DNA repair
| 1
USP51 inhibits DNA repair. 1 / 1
| 1
reach
"USP51 depletion leads to ionizing radiation hypersensitivity and dysregulated DNA repair [78]."
33797206
USP51 affects DNA Damage
| 1
USP51 activates DNA Damage. 1 / 1
| 1
reach
"The cell viability (Supplementary Figure S20C), colony formation (Supplementary Figure S20D), cell apoptosis (Supplementary Figure S20E‐F), and DNA damage detection assays (Supplementary Figure S20G‐H) further confirmed that overexpression of USP51 strongly reduced cell proliferation retardation and cell apoptosis but promoted DNA damage repair in response to DDP; however, USP51‐induced chemoresistant phenotypes were weakened by the addition of DHM."
37386737
USP51 affects DHM
| 1
USP51 binds DHM. 1 / 1
| 1
reach
"In line with this, the SPR binding assay validated a significantly increased binding affinity between USP51 and DHM (Figure 7D)."
37386737
USP51 affects DDX50
1 |
USP51 binds DDX50. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects DDX39A
1 |
USP51 binds DDX39A. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects DDX17
1 |
USP51 binds DDX17. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects DDB1
1 |
USP51 binds DDB1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects Cebpb
| 1
USP51 binds Cebpb. 1 / 1
| 1
sparser
"To validate the direct interaction between USP51 and DGCR8, we expressed and purified SFB-USP51 and MBP-DGCR8 proteins, and in vitro pulldown assays demonstrated that USP51 bound to DGCR8 (Fig.  xref ), indicating that DGCR8 may be directly regulated by USP51."
34188037
USP51 affects CUL2
1 |
USP51 binds CUL2. 1 / 1
1 |
biogrid
No evidence text available
37816999
USP51 affects CDK
| 1
CDK binds USP51 and USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
USP51 affects CDH2
| 1
USP51 activates CDH2. 1 / 1
| 1
reach
"In vitro , ectopic expression of USP51 up-regulates Zeb1 and the mesenchymal markers N-cadherin and Vimentin [ 77 ]."
30453041
USP51 affects CDH1
| 1
USP51 activates CDH1. 1 / 1
| 1
reach
"USP51 depletion inhibited the invasion of mesenchymal-like breast cancer cells by downregulating ZEB1 protein and mesenchymal marker expression and promoting E-cadherin upregulation."
39196911
USP51 affects CD44
| 1
USP51 increases the amount of CD44. 1 / 1
| 1
reach
"Knockdown of USP51 decreased the expression of CD44, NANOG, SOX2, OCT4, C-MYC, and EPCAM."
37422632
USP51 affects CD2AP
1 |
USP51 binds CD2AP. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP51 affects CBX3
1 |
USP51 binds CBX3. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects Bim stabilization
| 1
USP51 activates Bim stabilization. 1 / 1
| 1
eidos
"However , only knockdown of USP51 blocked up-regulation of Bim stabilization by hispidulin ( Figure 6C ) ."
31817696
USP51 affects BZLF1
| 1
USP51 binds BZLF1. 1 / 1
| 1
sparser
"Notably, overexpression of ZEB1 in A549/DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."
32468048
USP51 affects Actin
| 1
USP51 activates Actin. 1 / 1
| 1
reach
"As shown in Fig. 8 B-C, overexpression of USP51 resulted in significant upregulation of actin, while this effect was abolished after the intervention of ACTA2 expression ( Fig. 7 B-C, P < 0.05)."
36603607
USP51 affects ATXN7L2
1 |
ATXN7L2 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects ATXN7
1 |
ATXN7 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP51 affects AIFM1
1 |
USP51 binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
USP51 affects AHNAK2
1 |
USP51 binds AHNAK2. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP51 affects ACTA2
| 1
USP51 increases the amount of ACTA2. 1 / 1
| 1
reach
"The current study's findings showed that USP51 promotes ACTA2 transcription via ZEB1 to drive fibroblast activation and recruitment."
36603607
USP51 affects A549
| 1
USP51 binds Parkinson Disease and A549. 1 / 1
| 1
reach
"The results revealed that USP51 directly associated with PD‐L1 in A549 cells, which was further increased in A549 cells (Figure 5A)."
37386737
USP51 affects 53BP1 foci
| 1
USP51 inhibits 53BP1 foci. 1 / 1
| 1
eidos
"Depletion of USP51 also leads to an increase in 53BP1 foci formation , suggesting a role in deubiquitylating H2AK13 / 15 ( Wang et al ., 2016 ) ."
31164001
USP28 affects USP51
1 |
USP28 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP27X affects USP22
| 1
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP27X affects USP
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
USP22 affects USP27X, and USP51
| 1
USP27X binds USP51 and USP22. 1 / 1
| 1
sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
27132940
USP21 affects USP51
1 |
USP21 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP17L2 affects CDK
| 1
CDK binds USP51 and USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
USP15 affects USP51
1 |
USP15 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP affects USP51
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
U2AF2 affects USP51
1 |
USP51 binds U2AF2. 1 / 1
1 |
biogrid
No evidence text available
27132940
Tobacco Smoke Pollution decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
33660061
TRIM28 affects USP51
1 |
USP51 binds TRIM28. 1 / 1
1 |
biogrid
No evidence text available
27132940
TARDBP affects USP51
1 |
USP51 binds TARDBP. 1 / 1
1 |
biogrid
No evidence text available
27132940
TAF9B affects USP51
1 |
TAF9B binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
TAF6L affects USP51
1 |
USP51 binds TAF6L. 1 / 1
1 |
biogrid
No evidence text available
24981860
TAF5L affects USP51
1 |
TAF5L binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
TADA3 affects USP51
1 |
TADA3 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
TADA2B affects USP51
1 |
TADA2B binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
TADA1 affects USP51
1 |
TADA1 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
Stomach Neoplasms affects USP51
| 1
Stomach Neoplasms activates USP51. 1 / 1
| 1
reach
"Finally, it has been shown in vitro that GC cell-upregulated USP51 causes M2 macrophages to proliferate and become activated ( Fig. 9 N-O, P < 0.05)."
36603607
SUPT7L affects USP51
1 |
SUPT7L binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
SUPT20H affects USP51
1 |
SUPT20H binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
SPIN1 affects USP51
1 |
USP51 binds SPIN1. 1 / 1
1 |
biogrid
No evidence text available
27132940
SNRPD2 affects USP51
1 |
USP51 binds SNRPD2. 1 / 1
1 |
biogrid
No evidence text available
27132940
SLC25A5 affects USP51
1 |
USP51 binds SLC25A5. 1 / 1
1 |
biogrid
No evidence text available
27132940
SGF29 affects USP51
1 |
SGF29 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
S-nitrosoglutathione decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
38825487
Radiation affects USP51
| 1
Radiation activates USP51. 1 / 1
| 1
eidos
"The mechanism by which USP51 is upregulated by radiation remains to be determined ."
34188037
RUVBL1 affects USP51
1 |
USP51 binds RUVBL1. 1 / 1
1 |
biogrid
No evidence text available
27132940
RPS9 affects USP51
1 |
USP51 binds RPS9. 1 / 1
1 |
biogrid
No evidence text available
27132940
RBX1 affects USP51
1 |
USP51 binds RBX1. 1 / 1
1 |
biogrid
No evidence text available
37816999
RBM39 affects USP51
1 |
USP51 binds RBM39. 1 / 1
1 |
biogrid
No evidence text available
27132940
RBFOX2 affects USP51
1 |
USP51 binds RBFOX2. 1 / 1
1 |
biogrid
No evidence text available
27132940
RBBP7 affects USP51
1 |
USP51 binds RBBP7. 1 / 1
1 |
biogrid
No evidence text available
27132940
RBBP4 affects USP51
1 |
USP51 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
27132940
Parkinson Disease affects lysine residues K280
| 1
USP51 binds Parkinson Disease and lysine residues K280. 1 / 1
| 1
reach
"At the molecular level, USP51 directly bound and deubiquitinated PD‐L1 at lysine residues K280 and K281."
37386737
Parkinson Disease affects A549
| 1
USP51 binds Parkinson Disease and A549. 1 / 1
| 1
reach
"The results revealed that USP51 directly associated with PD‐L1 in A549 cells, which was further increased in A549 cells (Figure 5A)."
37386737
PLEC affects USP51
| 1
PLEC inhibits USP51. 1 / 1
| 1
sparser
"USP51, which is only modestly inhibited by hD1 at very high concentrations, is 70% identical in sequence to USP22."
34936860
PJA1 affects USP51
1 |
PJA1 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
PCNA affects USP51
1 |
USP51 binds PCNA. 1 / 1
1 |
biogrid
No evidence text available
27132940
PCBP1 affects USP51
1 |
USP51 binds PCBP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
PARP1 affects USP51
1 |
USP51 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
27132940
Neoplasms affects USP51
| 1
Neoplasms activates USP51. 1 / 1
| 1
reach
"According to the obtained data, many USP51-overexpressing tumors are immune exclusion tumors and, in particular, ACTA2 overexpression creates a restrictive barrier to protect tumors from killing by CD[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36603607
NPM1 affects USP51
1 |
USP51 binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
MGA affects USP51
1 |
USP51 binds MGA. 1 / 1
1 |
biogrid
No evidence text available
27132940
MDM2 affects USP51
1 |
USP51 binds MDM2. 1 / 1
1 |
biogrid
No evidence text available
33961781
MAZ affects USP51
1 |
MAZ decreases the amount of USP51. 1 / 1
1 |
biopax:msigdb
No evidence text available
MATR3 affects USP51
1 |
USP51 binds MATR3. 1 / 1
1 |
biogrid
No evidence text available
27132940
LUC7L3 affects USP51
1 |
USP51 binds LUC7L3. 1 / 1
1 |
biogrid
No evidence text available
27132940
LBR affects USP51
1 |
USP51 binds LBR. 1 / 1
1 |
biogrid
No evidence text available
33961781
KAT2B affects USP51
1 |
KAT2B binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
JMY affects USP51
1 |
USP51 binds JMY. 1 / 1
1 |
biogrid
No evidence text available
33961781
His2A affects USP51
| 1
USP51 binds His2A. 1 / 1
| 1
reach
"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15 ub."
27083998
HSPA9 affects USP51
1 |
USP51 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
27132940
HSPA8 affects USP51
1 |
USP51 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
27132940
HSPA1A affects USP51
1 |
USP51 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
27132940
HNRNPH2 affects USP51
1 |
USP51 binds HNRNPH2. 1 / 1
1 |
biogrid
No evidence text available
27132940
HNRNPF affects USP51
1 |
USP51 binds HNRNPF. 1 / 1
1 |
biogrid
No evidence text available
27132940
HNF4A affects USP51
1 |
HNF4A decreases the amount of USP51. 1 / 1
1 |
biopax:msigdb
No evidence text available
HAND1 affects USP51
1 |
HAND1 decreases the amount of USP51. 1 / 1
1 |
biopax:msigdb
No evidence text available
H1-3 affects USP51
1 |
USP51 binds H1-3. 1 / 1
1 |
biogrid
No evidence text available
33961781
Gentamicins affects USP51
1 |
Gentamicins decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
33387578
GSTA1 affects USP51
1 |
USP51 binds GSTA1. 1 / 1
1 |
biogrid
No evidence text available
33961781
FBL affects USP51
1 |
USP51 binds FBL. 1 / 1
1 |
biogrid
No evidence text available
27132940
ESRRA affects USP51
1 |
ESRRA decreases the amount of USP51. 1 / 1
1 |
biopax:msigdb
No evidence text available
ENY2 affects USP27X
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
EIF4A1 affects USP51
1 |
USP51 binds EIF4A1. 1 / 1
1 |
biogrid
No evidence text available
27132940
EGFP affects USP51
| 1
USP51 binds EGFP. 1 / 1
| 1
sparser
"In cells, H2A and its modified species could be coimmunoprecipitated with EGFP-USP51 ( xref B)."
27083998
E3_Ub_ligase affects USP51
| 1
sparser
"Mechanically, USP51 directly binds to Elongin C (ELOC) and forms a larger functional complex with VHL E3 ligase (USP51/VHL/CUL2/ELOB/ELOC/RBX1) to regulate the ubiquitin-dependent proteasomal degradation of HIF1A."
37816999
DNAJA2 affects USP51
1 |
USP51 binds DNAJA2. 1 / 1
1 |
biogrid
No evidence text available
27132940
DDX50 affects USP51
1 |
USP51 binds DDX50. 1 / 1
1 |
biogrid
No evidence text available
27132940
DDX39A affects USP51
1 |
USP51 binds DDX39A. 1 / 1
1 |
biogrid
No evidence text available
27132940
DDX17 affects USP51
1 |
USP51 binds DDX17. 1 / 1
1 |
biogrid
No evidence text available
27132940
DDB1 affects USP51
1 |
USP51 binds DDB1. 1 / 1
1 |
biogrid
No evidence text available
27132940
Cebpb affects USP51
| 1
USP51 binds Cebpb. 1 / 1
| 1
sparser
"To validate the direct interaction between USP51 and DGCR8, we expressed and purified SFB-USP51 and MBP-DGCR8 proteins, and in vitro pulldown assays demonstrated that USP51 bound to DGCR8 (Fig.  xref ), indicating that DGCR8 may be directly regulated by USP51."
34188037
CUL2 affects USP51
1 |
USP51 binds CUL2. 1 / 1
1 |
biogrid
No evidence text available
37816999
CDK4/6 kinases affects USP51
| 1
CDK4/6 kinases activates USP51. 1 / 1
| 1
reach
"CDK4/6 kinases phosphorylate and stimulate deubiquitinase USP51, which stabilises ZEB1 [90] (Fig. 2)."
37259089
CDK affects USP17L2, and USP51
| 1
CDK binds USP51 and USP17L2. 1 / 1
| 1
sparser
"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
34204543
CD2AP affects USP51
1 |
USP51 binds CD2AP. 1 / 1
1 |
biogrid
No evidence text available
33961781
CBX3 affects USP51
1 |
USP51 binds CBX3. 1 / 1
1 |
biogrid
No evidence text available
27132940
BZLF1 affects USP51
| 1
USP51 binds BZLF1. 1 / 1
| 1
sparser
"Notably, overexpression of ZEB1 in A549/DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."
32468048
Acrylamide affects USP51
1 |
Acrylamide increases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
32763439
ATXN7L3 affects USP27X
| 1
ATXN7L3 binds ENY2, USP, USP27X, and USP51. 1 / 1
| 1
sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
27923209
ATXN7L2 affects USP51
1 |
ATXN7L2 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
ATXN7 affects USP51
1 |
ATXN7 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
24981860
AMPK affects USP51
| 1
AMPK increases the amount of USP51. 1 / 1
| 1
sparser
"Therefore, our data suggested that hispidulin increased Bim protein stability via AMPK-induced USP51 expression."
31817696
AIFM1 affects USP51
1 |
USP51 binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
27132940
AHNAK2 affects USP51
1 |
USP51 binds AHNAK2. 1 / 1
1 |
biogrid
No evidence text available
33961781
A549 affects USP51
| 1
USP51 binds Parkinson Disease and A549. 1 / 1
| 1
reach
"The results revealed that USP51 directly associated with PD‐L1 in A549 cells, which was further increased in A549 cells (Figure 5A)."
37386737
2-palmitoylglycerol increases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
37199045
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP51. 1 / 1
1 |
ctd
No evidence text available
33387578