IndraLab

"Rather, the co-IP assay demonstrated that USP51 interacted with ZEB1 in A549/DDP cells ( xref ), and that USP51 knockdown promoted the ubiquitination and degradation of the ZEB1 protein ( xref )."

32468048

USP51 activates ZEB1.

| 2 3

USP51 activates ZEB1. 5 / 5

| 2 3

➶

reach

"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."

35058607

➶

eidos

"In addition , knockdown of USP51 in A549 / DDP cells significantly induced apoptosis , decreased ZEB1 expression and increased cleaved poly ADP-ribose polymerase 1 ( PARP1 ) and cleaved caspase-3 levels ."

32468048

➶

reach

"Among DUBs, ubiquitin specific peptidase 51 (USP51) binds to the N-terminal of ZEB1 and increases ZEB1 protein stability in breast cancer cell lines [XREF_BIBR]."

33808323

➶

eidos

"Thus , the deubiquitinases ( DUBs ) were involved in counteracting polyubiquitination and proteasomal degradation of ZEB1 [ 40 ] ; these DUBs include USP51 , which upregulated ZEB1 and the mesenchymal markers by binding , deubiquitinating , and stabilizing ZEB1 [ 41 ] ."

32014049

➶

reach

"Conversely, overexpression of USP51 in epithelial cells resulted in upregulation of ZEB1 and mesenchymal markers."

29119051

USP51 deubiquitinates ZEB1.

1 | 2

USP51 leads to the deubiquitination of ZEB1. 3 / 3

1 | 2

➶

ubibrowser

"By screening a human deubiquitinase library, we identified USP51 as a deubiquitinase that binds, deubiquitinates, and stabilizes ZEB1."

29119051

➶

reach

"Lastly, knockdown of USP51 promoted ZEB1 ubiquitination, leading to ZEB1 degradation."

32468048

➶

reach

"USP51 promotes deubiquitination and stabilization of ZEB1."

29119051

USP51 increases the amount of ZEB1.

| 1

USP51 increases the amount of ZEB1. 1 / 1

| 1

➶

reach

"In addition, knockdown of USP51 in A549 and DDP cells significantly induced apoptosis, decreased ZEB1 expression and increased cleaved poly ADP-ribose polymerase 1 (PARP1) and cleaved caspase-3 levels."

32468048

ENY2 affects USP51

| 4 5

ENY2 binds USP51.

| 3 5

USP51 binds ENY2 and ATXN7L3. 3 / 3

| 3

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."

27132940

➶

sparser

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( Figure 4 C, lanes 5 and 6)."

27132940

USP51 binds ENY2. 3 / 3

| 3

➶

reach

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

27132940

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."

27132940

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

ENY2 deubiquitinates USP51.

| 1

ENY2 deubiquitinates USP51. 1 / 1

| 1

➶

reach

"Our results now reveal that in addition to USP22, ATXN7L3 and ENY2 activate two previously uncharacterized deubiquitinating enzymes, USP27X and USP51, which are not part of SAGA."

27132940

ATXN7L3 affects USP51

| 4 5

ATXN7L3 binds USP51.

| 3 5

USP51 binds ATXN7L3. 3 / 3

| 3

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."

27132940

➶

reach

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

27132940

USP51 binds ENY2 and ATXN7L3. 3 / 3

| 3

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."

27132940

➶

sparser

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( Figure 4 C, lanes 5 and 6)."

27132940

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

ATXN7L3 deubiquitinates USP51.

| 1

ATXN7L3 deubiquitinates USP51. 1 / 1

| 1

➶

reach

"Our results now reveal that in addition to USP22, ATXN7L3 and ENY2 activate two previously uncharacterized deubiquitinating enzymes, USP27X and USP51, which are not part of SAGA."

27132940

USP51 affects ENY2

| 3 5

USP51 binds ENY2 and ATXN7L3. 3 / 3

| 3

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."

27132940

➶

sparser

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( Figure 4 C, lanes 5 and 6)."

27132940

USP51 binds ENY2. 3 / 3

| 3

➶

reach

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

27132940

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."

27132940

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

USP51 affects ATXN7L3

| 3 5

USP51 binds ATXN7L3. 3 / 3

| 3

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."

27132940

➶

reach

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

reach

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

27132940

USP51 binds ENY2 and ATXN7L3. 3 / 3

| 3

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."

27132940

➶

sparser

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( Figure 4 C, lanes 5 and 6)."

27132940

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

USP51 is modified

1 | 3 4

USP51 is phosphorylated.

1 | 4

USP51 is phosphorylated. 4 / 4

| 4

➶

sparser

"Notably, the high expression of p -RB, p -USP51, and ZEB1 was significantly correlated with a poor clinical outcome."

32195004

➶

sparser

"Moreover, we found a strong positive correlation between the expression of p -RB (an indicator of CDK4/6 activity), p -USP51 and ZEB1 in metastatic human breast cancer samples."

32195004

➶

sparser

"In terms of molecular mechanism, USP51 is phosphorylated and activated by CDK4/6, thus resulting in the deubiquitination and stabilization of ZEB1 protein."

35058607

➶

sparser

"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."

34204543

USP51 is phosphorylated on S26. 1 / 1

1 |

➶

hprd

No evidence text available

19664994

USP51 is deubiquitinated.

| 3

USP51 is deubiquitinated. 3 / 3

| 3

➶

trips

"CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism."

32296027

➶

trips

"Correction to: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism."

34145216

➶

trips

"CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism."

32195004

ZEB1 affects USP51

1 3 | 1 2

ZEB1 binds USP51.

3 | 2

ZEB1 binds USP51. 5 / 5

3 | 2

➶

biogrid

No evidence text available

29119051

➶

sparser

"USP51 interacted with ZEB1, and knockdown of USP51 markedly induced ubiquitin-mediated degradation of ZEB1."

32468048

➶

biogrid

No evidence text available

29119051

➶

biogrid

No evidence text available

29119051

➶

sparser

"Rather, the co-IP assay demonstrated that USP51 interacted with ZEB1 in A549/DDP cells ( xref ), and that USP51 knockdown promoted the ubiquitination and degradation of the ZEB1 protein ( xref )."

32468048

ZEB1 decreases the amount of USP51.

1 |

ZEB1 decreases the amount of USP51. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

ZEB1 activates USP51.

| 1

ZEB1 activates USP51. 1 / 1

| 1

➶

reach

"Notably, overexpression of ZEB1 in A549 and DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."

32468048

USP51 affects USP27X

| 7

USP51 binds USP27X. 4 / 4

| 4

➶

sparser

"The reduced tumor burden upon depletion of USP27X prompted us to search the The Cancer Genome Atlas (TCGA) database to see if altered expression of USP27X or USP51 is associated with certain cancer phenotypes."

27132940

➶

sparser

"Interestingly, one of the USP27X and USP51 associated proteins, C1QBP, was originally described as a mitochondrial protein ( Dedio et al., 1998 )."

27132940

➶

sparser

"Interestingly, one of the USP27X and USP51 associated proteins, C1QBP, was originally described as a mitochondrial protein ( xref )."

27132940

➶

sparser

"The reduced tumor burden upon depletion of USP27X prompted us to search The Cancer Genome Atlas (TCGA) database to see if altered expression of USP27X or USP51 is associated with certain cancer phenot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

27132940

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

USP22 binds USP51 and USP27X. 1 / 1

| 1

➶

sparser

"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."

27132940

USP22 affects USP51

| 4 3

USP22 binds USP51.

| 3

USP22 binds USP51. 2 / 2

| 2

➶

sparser

"To test this idea, we expressed wild type (WT) or mutant forms of USP22, USP27X and USP51 in which a conserved cysteine required for activity in USP22 is changed to serine in 293T cells ( xref )."

27132940

➶

sparser

"To test this idea, we expressed wild-type (WT) or mutant forms of USP22, USP27X, and USP51 in which a conserved cysteine required for activity in USP22 is changed to serine in 293T cells ( Figures 3 A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

27132940

USP22 binds USP51 and USP27X. 1 / 1

| 1

➶

sparser

27132940

USP22 inhibits USP51.

| 2

USP22 inhibits USP51. 2 / 2

| 2

➶

reach

"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5 associated proteins after shRNA mediated depletion of USP22."

27132940

➶

reach

"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5 associated proteins after shRNA mediated depletion of USP22 (XREF_FIG, lanes 2 and 3 and 5 and 6)."

27132940

USP22 activates USP51.

| 2

USP22 activates USP51. 2 / 2

| 2

➶

reach

"Equal numbers of cells expressing shRNAs that specifically target USP27X or USP51, but not USP22 (XREF_FIG), or expressing control shRNA, were seeded and monitored for proliferation by cell counts 72 hours later."

27132940

➶

reach

"Equal numbers of cells expressing shRNAs that specifically target USP27X or USP51, but not USP22, or expressing control shRNA, were seeded and monitored for proliferation by cell counts 72 hr later."

27132940

Cdk-4 affects USP51

| 3 3

Cdk-4 phosphorylates USP51.

| 3 2

Cdk-4 phosphorylates USP51. 5 / 5

| 3 2

➶

sparser

"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."

32195004

➶

reach

"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."

32195004

➶

sparser

"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."

32296027

➶

reach

"In terms of molecular mechanism, USP51 is phosphorylated and activated by CDK4/6, thus resulting in the deubiquitination and stabilization of ZEB1 protein."

35058607

➶

reach

"The phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ZEB1."

32296027

Cdk-4 binds USP51.

| 1

USP51 binds cdk-4. 1 / 1

| 1

➶

sparser

"CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB1."

35058607

USP51 affects DGCR8

| 1 5

USP51 binds DGCR8.

| 5

USP51 binds DGCR8. 5 / 5

| 5

➶

sparser

"Moreover, the interaction between DGCR8 and USP51 was enhanced in a time-dependent manner after irradiation of LM2 cells (Supplementary Fig. xref ), and this increased interaction was observed with endogenous proteins (Fig. xref )."

34188037

➶

sparser

"To validate the direct interaction between USP51 and DGCR8, we expressed and purified SFB-USP51 and MBP-DGCR8 proteins, and in vitro pulldown assays demonstrated that USP51 bound to DGCR8 (Fig. xref ), indicating that DGCR8 may be directly regulated by USP51."

34188037

➶

sparser

"Furthermore, our results demonstrate that USP51 directly binds and deubiquitinates DGCR8 in a K48 linkage-specific manner, and that this deubiquitination is enhanced by IR treatment."

34188037

➶

sparser

"Collectively, these results suggest that after irradiation, ATM-dependent phosphorylation of DGCR8 at S677 is crucial for the recruitment of the DGCR8-RNF168 complex to MDC1 and RNF8 at DSBs, as well as the subsequent interaction of DGCR8 with USP51, DGCR8 deubiquitination, histone ubiquitination, and DSB repair."

34188037

➶

sparser

"Consistent with the results in Supplementary Fig. xref , the interaction between WT DGCR8 and USP51 was enhanced at 8 h, but not at 1 h, after IR, and this increased interaction was abolished by the phosphodeficient mutation (S677A), but not by the phosphomimetic mutation (S677D) (Fig. xref )."

34188037

USP51 activates DGCR8.

| 1

USP51 activates DGCR8. 1 / 1

| 1

➶

reach

"Upon radiation, the kinase ATM and the deubiquitinase USP51 mediate the activation and stabilization of DGCR8 through phosphorylation and deubiquitination."

34188037

USP51 affects FAT4

| 4 1

USP51 binds FAT4.

| 2 1

USP51 binds FAT4. 3 / 3

| 2 1

➶

sparser

"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4's function in EC."

31217854

➶

reach

"FAT4 and USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway."

31217854

➶

reach

"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4 's function in EC."

31217854

USP51 increases the amount of FAT4.

| 1

Modified USP51 increases the amount of FAT4. 1 / 1

| 1

➶

reach

"Ablating USP51 by shRNA decreased cellular FAT4 protein level while overexpression of USP51 increased FAT4 protein level."

31217854

USP51 decreases the amount of FAT4.

| 1

USP51 decreases the amount of FAT4. 1 / 1

| 1

➶

reach

"Ablating USP51 by shRNA decreased cellular FAT4 protein level while overexpression of USP51 increased FAT4 protein level."

31217854

ENY2 affects ATXN7L3

| 5

USP51 binds ENY2 and ATXN7L3. 3 / 3

| 3

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."

27132940

➶

sparser

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( Figure 4 C, lanes 5 and 6)."

27132940

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

DGCR8 affects USP51

| 5

USP51 binds DGCR8. 5 / 5

| 5

➶

sparser

34188037

➶

sparser

34188037

➶

sparser

"Furthermore, our results demonstrate that USP51 directly binds and deubiquitinates DGCR8 in a K48 linkage-specific manner, and that this deubiquitination is enhanced by IR treatment."

34188037

➶

sparser

34188037

➶

sparser

34188037

ATXN7L3 affects ENY2

| 5

USP51 binds ENY2 and ATXN7L3. 3 / 3

| 3

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."

27132940

➶

sparser

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( Figure 4 C, lanes 5 and 6)."

27132940

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

USP51 affects Histone_H2B

| 3 1

USP51 deubiquitinates Histone_H2B.

| 3

USP51 deubiquitinates Histone_H2B. 3 / 3

| 3

➶

reach

"Remarkably, this inhibitor also showed greater activity on USP22 than on two other DUBs, USP27x and USP51, that also deubiquitinate histone H2B and form complexes with two of the SAGA DUB module adaptor subunits."

34936860

➶

reach

"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that the ATXN7L3 zinc finger plays a role analogous to that of the Sgf11 zinc finger in docking human SAGA DUB [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

27923209

➶

reach

"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that all three use the ATXN7L3 zinc finger to dock the H2A and H2B acidic patch in a manner similar to that shown in the structure of the yeast DUB module bound to ubiquitinated nucleosomes."

27923209

USP51 binds Histone_H2B.

| 1

Histone_H2B binds USP51 and H2AC20. 1 / 1

| 1

➶

sparser

"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15ub."

27083998

USP51 affects H2AC20

2 1 | 1

USP51 binds H2AC20.

2 | 1

USP51 binds H2AC20. 2 / 2

2 |

➶

biogrid

No evidence text available

27083998

➶

biogrid

No evidence text available

27083998

Histone_H2B binds USP51 and H2AC20. 1 / 1

| 1

➶

sparser

"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15ub."

27083998

USP51 deubiquitinates H2AC20.

1 |

USP51 deubiquitinates H2AC20. 1 / 1

1 |

➶

ubibrowser

"USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response."

27083998

HDAC1 affects USP51

| 1 2 1

HDAC1 inhibits USP51. 4 / 4

| 1 2 1

➶

eidos

"USP51 , which is only modestly inhibited by hD1 at very high concentrations , is 70 % identical in sequence to USP22 ."

34936860

➶

reach

"USP51, which is only modestly inhibited by hD1 at very high concentrations, is 70% identical in sequence to USP22."

34936860

➶

reach

"As shown in Figure 5B, hD1 inhibits the USP27x complex at >25-fold higher inhibitor concentrations and modestly inhibits the USP51 complex only at >2500-fold higher concentration than that needed to inhibit the human DUB module."

34936860

➶

sparser

"USP51, which is only modestly inhibited by hD1 at very high concentrations, is 70% identical in sequence to USP22."

34936860

Valproic acid affects USP51

3 |

Valproic acid decreases the amount of USP51. 3 / 3

3 |

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

23179753

➶

ctd

No evidence text available

28001369

Hsa-miR-5011-5p affects USP51

3 |

Hsa-miR-5011-5p decreases the amount of USP51. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

23313552

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-4798-3p affects USP51

3 |

Hsa-miR-4798-3p decreases the amount of USP51. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23313552

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-377-3p affects USP51

3 |

Hsa-miR-377-3p decreases the amount of USP51. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23313552

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-3680-5p affects USP51

3 |

Hsa-miR-3680-5p decreases the amount of USP51. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

23313552

Hsa-miR-342-3p affects USP51

3 |

Hsa-miR-342-3p decreases the amount of USP51. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23313552

Hsa-miR-190a-3p affects USP51

3 |

Hsa-miR-190a-3p decreases the amount of USP51. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23313552

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-1277-5p affects USP51

3 |

Hsa-miR-1277-5p decreases the amount of USP51. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

23313552

➶

biopax:mirtarbase

No evidence text available

21572407

End3 affects USP51

| 3

USP51 binds end3. 3 / 3

| 3

➶

sparser

"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5-associated proteins after shRNA-mediated depletion of USP22 ( xref , lanes 2 and 3 and 5 and 6)."

27132940

➶

sparser

"USP27X and USP51 Do Not Associate with SAGA."

27132940

➶

sparser

"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5-associated proteins after shRNA-mediated depletion of USP22 ( Figure 4 D, lanes 2 and 3 and 5 and 6)."

27132940

USP51 affects USP22

| 3

USP22 binds USP51. 2 / 2

| 2

➶

sparser

"To test this idea, we expressed wild type (WT) or mutant forms of USP22, USP27X and USP51 in which a conserved cysteine required for activity in USP22 is changed to serine in 293T cells ( xref )."

27132940

➶

sparser

27132940

USP22 binds USP51 and USP27X. 1 / 1

| 1

➶

sparser

27132940

USP51 affects USP

| 1 2

USP51 binds USP.

| 2

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

USP51 inhibits USP.

| 1

USP51 inhibits USP. 1 / 1

| 1

➶

reach

"These analyses revealed a substantial overlap of altered genes between the depletion of each of the three USPs, including 340 commonly affected genes (p-value 1.1e-130 by Fisher 's exact test) in USP27X and USP51 depleted cells, 283 (p-value 3.3e-34) commonly affected genes in USP22 and USP27X depleted cells, 249 commonly affected genes (p-value 1.1e-74) in USP22 and USP51 depleted cells, and 137 commonly altered genes in all three USP depletions (~ 10% of all altered genes) (XREF_FIG)."

27132940

USP51 affects TWIST1

| 3

USP51 deubiquitinates TWIST1. 3 / 3

| 3

➶

reach

"Our results show that USP51 maintains the stemness of NSCLC cells by deubiquitinating TWIST1."

37422632

➶

reach

"We found that USP51 deubiquitinates TWIST1, which is significantly upregulated in the tissues of patients with NSCLC and is closely associated with poor prognosis."

37422632

➶

reach

"USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1."

37422632

USP51 affects Neoplasm Metastasis

| 2 1

USP51 activates Neoplasm Metastasis. 3 / 3

| 2 1

➶

reach

"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."

35058607

➶

eidos

"Moreover , we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1 , which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma ."

35058607

➶

eidos

"We found that the knockdown of USP51 resulted in significantly decreased lung metastasis ; however , this effect was attenuated in mice carrying ZEB1-expressing tumors ( Fig. 3e , f ) , confirming that the knockdown of USP51 reduces cancer metastasis through the regulation of ZEB1 in vivo ."

32195004

USP51 affects H2AK13,15ub

| 3

USP51 deubiquitinates H2AK13,15ub. 3 / 3

| 3

➶

reach

"Here we show that USP51, a previously uncharacterized DUB, deubiquitylates H2AK13,15 ub and regulates DNA damage response."

27083998

➶

reach

"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15 ub."

27083998

➶

reach

"USP51 deubiquitylates H2AK13,15 ub and regulates DNA damage response."

27083998

H2AC20 affects USP51

2 | 1

USP51 binds H2AC20. 2 / 2

2 |

➶

biogrid

No evidence text available

27083998

➶

biogrid

No evidence text available

27083998

Histone_H2B binds USP51 and H2AC20. 1 / 1

| 1

➶

sparser

"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15ub."

27083998

FAT4 affects USP51

| 2 1

USP51 binds FAT4. 3 / 3

| 2 1

➶

sparser

"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4's function in EC."

31217854

➶

reach

"FAT4 and USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway."

31217854

➶

reach

"Coimmunoprecipitation confirmed the direct binding of FAT4 and USP51 which was essential for FAT4 's function in EC."

31217854

ATXN7L3 affects ENY2, and USP51

| 3

USP51 binds ENY2 and ATXN7L3. 3 / 3

| 3

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( xref , lanes 5 and 6)."

27132940

➶

sparser

"ATXN7L3 and ENY2 associate with USP27X and USP51."

27132940

➶

sparser

"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations ( Figure 4 C, lanes 5 and 6)."

27132940

Nickel atom affects USP51

2 |

Nickel atom decreases the amount of USP51. 2 / 2

2 |

➶

ctd

No evidence text available

25583101

➶

ctd

No evidence text available

24768652

Hsa-miR-362-3p affects USP51

2 |

Hsa-miR-362-3p decreases the amount of USP51. 2 / 2

2 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-329-3p affects USP51

2 |

Hsa-miR-329-3p decreases the amount of USP51. 2 / 2

2 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Furan affects USP51

2 |

Furan methylates USP51.

1 |

Furan methylates USP51. 1 / 1

1 |

➶

ctd

No evidence text available

22079235

Furan decreases the amount of USP51.

1 |

Furan decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

26194646

ZEB affects USP51

| 1 1

USP51 binds ZEB. 1 / 1

| 1

➶

sparser

"Notably, overexpression of ZEB1 in A549/DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."

32468048

USP51 binds ZEB. 1 / 1

| 1

➶

reach

"Notably, overexpression of ZEB1 in A549 and DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."

32468048

USP51 affects cell population proliferation

| 2

USP51 inhibits cell population proliferation. 2 / 2

| 2

➶

reach

"In conclusion, suppression of FAT4 by inactivation of deubiquitinating enzyme USP51 promoted proliferation and invasion of EC cells via inhibiting Hippo pathway."

31217854

➶

reach

"Knockdown of USP51 decreases the cell proliferation and halts the cell cycle at G0/G1 phase."

32486158

USP51 affects ZEB

| 1 1

USP51 binds ZEB. 1 / 1

| 1

➶

sparser

"Notably, overexpression of ZEB1 in A549/DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."

32468048

USP51 binds ZEB. 1 / 1

| 1

➶

reach

"Notably, overexpression of ZEB1 in A549 and DDP cells potently attenuated the effects of USP51 knockdown on apoptosis, and co-IP experiments further demonstrated interaction between USP51 and ZEB."

32468048

USP51 affects USP17L2

| 2

USP51 binds USP17L2. 1 / 1

| 1

➶

sparser

34204543

CDK binds USP51 and USP17L2. 1 / 1

| 1

➶

sparser

34204543

USP51 affects Neoplasms

| 2

USP51 activates Neoplasms. 2 / 2

| 2

➶

reach

"Finally, USP51 knockdown weakened cisplatin resistance in A549/DDP cells and significantly suppressed tumor growth in vivo, suggesting that a USP51 inhibitor combined with cisplatin may be considered as an effective treatment strategy to eliminate drug-resistant lung cancer cells."

35856403

➶

reach

"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."

35058607

USP51 affects Neoplasm Invasiveness

| 1 1

USP51 activates Neoplasm Invasiveness. 2 / 2

| 1 1

➶

reach

"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."

35058607

➶

eidos

35058607

USP51 affects H2Aub1

| 2

USP51 deubiquitinates H2Aub1. 2 / 2

| 2

➶

reach

"As was previously shown for the USP22 DUBm, both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1 (XREF_FIG and XREF_SUPPLEMENTARY)."

27132940

➶

reach

"As was previously shown for the USP22 DUBm (Zhang et al., 2008a; Zhao et al., 2008), both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1."

27132940

USP51 affects DNA damage checkpoint

| 2

USP51 inhibits DNA damage checkpoint. 2 / 2

| 2

➶

reach

"USP51 depletion results in increased spontaneous DNA damage foci and elevated levels of H2AK15ub and impairs DNA damage response."

27083998

➶

reach

"The role of USP51 in attenuating chemosensitivity of lung cancer cells to cisplatin by regulating DNA damage response."

35856403

USP51 affects CTNNB1

| 1 1

USP51 binds CTNNB1. 2 / 2

| 1 1

➶

reach

"USP51 interacts with beta-catenin and reduces ubiquitination of beta-catenin."

32486158

➶

sparser

"USP51 interacts with β-catenin and reduces ubiquitination of β-catenin."

32486158

USP27X affects USP

| 2

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

USP17L2 affects USP51

| 2

USP51 binds USP17L2. 1 / 1

| 1

➶

sparser

34204543

CDK binds USP51 and USP17L2. 1 / 1

| 1

➶

sparser

34204543

USP affects USP51

| 2

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

CTNNB1 affects USP51

| 1 1

USP51 binds CTNNB1. 2 / 2

| 1 1

➶

reach

"USP51 interacts with beta-catenin and reduces ubiquitination of beta-catenin."

32486158

➶

sparser

"USP51 interacts with β-catenin and reduces ubiquitination of β-catenin."

32486158

CDK4 affects USP51

| 2

CDK4 activates USP51. 2 / 2

| 2

➶

eidos

"The phosphorylation and activation of USP51 by CDK4 / 6 is necessary to deubiquitinate and stabilize ZEB1 ."

32195004

➶

eidos

"At the molecular level , CDK4 / 6 phosphorylates and activates USP51 , which is then responsible for the deubiquitination and stabilization of ZEB1 ."

32195004

CDK affects USP51

| 2

CDK phosphorylates USP51.

| 1

CDK phosphorylates USP51. 1 / 1

| 1

➶

sparser

34204543

CDK binds USP51.

| 1

CDK binds USP51 and USP17L2. 1 / 1

| 1

➶

sparser

34204543

ATXN7L3 affects USP27X

| 2

USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2

| 2

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

27923209

➶

sparser

"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

27923209

6-propyl-2-thiouracil affects USP51

2 |

6-propyl-2-thiouracil increases the amount of USP51. 2 / 2

2 |

➶

ctd

No evidence text available

24780913

➶

ctd

No evidence text available

25825206

Treatment palbociclib Lee011 affects USP51

| 1

Treatment palbociclib Lee011 inhibits USP51. 1 / 1

| 1

➶

eidos

"Instead , treatment with palbociclib and Lee011 induced the inactivation of USP51 , the destabilization of ZEB1 protein and a decrease in cell migration , thereby reducing the degree of TNBC metastasis both in vitro and in vivo ."

32195004

Titanium dioxide affects USP51

1 |

Titanium dioxide decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

29264374

Thimerosal affects USP51

1 |

Thimerosal decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Terbufos affects USP51

1 |

Terbufos methylates USP51. 1 / 1

1 |

➶

ctd

No evidence text available

22847954

Sunitinib affects USP51

1 |

Sunitinib increases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Sodium arsenite affects USP51

1 |

Sodium arsenite increases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

29301061

Silver(0) affects USP51

1 |

Silver(0) decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

27131904

Parathion affects USP51

1 |

Parathion methylates USP51. 1 / 1

1 |

➶

ctd

No evidence text available

22847954

Methylmercury chloride affects USP51

1 |

Methylmercury chloride decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

28001369

Methyl methanesulfonate affects USP51

1 |

Methyl methanesulfonate increases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Hydroquinone affects USP51

1 |

Hydroquinone decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

31256213

Hsa-miR-95-5p affects USP51

1 |

Hsa-miR-95-5p decreases the amount of USP51. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22012620

Hsa-miR-4719 affects USP51

1 |

Hsa-miR-4719 decreases the amount of USP51. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22012620

Hsa-miR-4705 affects USP51

1 |

Hsa-miR-4705 decreases the amount of USP51. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22012620

Hsa-miR-4668-3p affects USP51

1 |

Hsa-miR-4668-3p decreases the amount of USP51. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22012620

Hsa-miR-338-5p affects USP51

1 |

Hsa-miR-338-5p decreases the amount of USP51. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22012620

Hsa-miR-3163 affects USP51

1 |

Hsa-miR-3163 decreases the amount of USP51. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22012620

Hsa-miR-187-5p affects USP51

1 |

Hsa-miR-187-5p decreases the amount of USP51. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22012620

Fonofos affects USP51

1 |

Fonofos methylates USP51. 1 / 1

1 |

➶

ctd

No evidence text available

22847954

Bisphenol A affects USP51

1 |

Bisphenol A decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

25181051

Atrazine affects USP51

1 |

Atrazine increases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

22378314

Abrine affects USP51

1 |

Abrine decreases the amount of USP51. 1 / 1

1 |

➶

ctd

No evidence text available

31054353

ZIC1 affects USP51

1 |

ZIC1 decreases the amount of USP51. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

USP51 affects vimentin MDA-MB-231 SUM-159 cells

| 1

USP51 activates vimentin MDA-MB-231 SUM-159 cells. 1 / 1

| 1

➶

eidos

"Western blotting showed that the downregulation of USP51 resulted in increased E-cadherin expression but decreased vimentin and N-cadherin expression in MDA-MB-231 and SUM-159 cells ( Fig. 3a ) ."

32195004

USP51 affects ubiquitination WT DGCR8 S677D mutant

| 1

USP51 inhibits ubiquitination WT DGCR8 S677D mutant. 1 / 1

| 1

➶

eidos

"Moreover , USP51 markedly reduced the ubiquitination of either WT DGCR8 or the S677D mutant , but had little effect on the ubiquitination of the S677A mutant ( Fig. 8c) ."

34188037

USP51 affects tumor growth

| 1

USP51 activates tumor growth. 1 / 1

| 1

➶

eidos

"Finally , USP51 knockdown weakened cisplatin resistance in A549 / DDP cells and significantly suppressed tumor growth in vivo , suggesting that a USP51 inhibitor combined with cisplatin may be considered as an effective treatment strategy to eliminate drug-resistant lung cancer cells ."

35856403

USP51 affects recruitment RNF168 53BP1 BRCA1 DSBs

| 1

USP51 activates recruitment RNF168 53BP1 BRCA1 DSBs. 1 / 1

| 1

➶

eidos

"Similar to the DGCR8-knockdown effects ( Fig. 3a , b , f ) , knockdown of USP51 not only decreased HR and NHEJ repair efficiency in LM2-DRR cells ( Fig. 5e and Supplementary Fig. 5c , d ) , but also abrogated the recruitment of RNF168 , 53BP1 , and BRCA1 to DSBs after radiation treatment , without affecting the recruitment of MDC1 and RNF8 ( Fig. 5f and Supplementary Fig. 6 ) ."

34188037

USP51 affects polyubiquitination ZEB1 protein

| 1

USP51 inhibits polyubiquitination ZEB1 protein. 1 / 1

| 1

➶

eidos

"Taken together with the results of the ubiquitination assay showing that USP51 knockdown led to increased polyubiquitination of the ZEB1 protein upon MG132 treatment ( Fig. 2i ) , the above observations collectively suggested that USP51 is a bona fide DUB that targets the ZEB1 protein for deubiquitination and stabilization ."

32195004

USP51 affects poly-ubiquitination H2A induced RNF8 RNF168

| 1

USP51 activates poly-ubiquitination H2A induced RNF8 RNF168. 1 / 1

| 1

➶

eidos

"Moreover , the mono - , di - , and poly-ubiquitination of H2A induced by RNF8 and RNF168 upon IR was abolished by USP51 knockdown ( Fig. 5g ) ."

34188037

USP51 affects mesenchymal markers

| 1

USP51 activates mesenchymal markers. 1 / 1

| 1

➶

eidos

32014049

USP51 affects mesenchymal markers including vimentin

| 1

USP51 activates mesenchymal markers including vimentin. 1 / 1

| 1

➶

eidos

"Consequently , USP51 upregulates the mesenchymal markers including N-cadherin and vimentin [ 171 ] ."

33808323

USP51 affects lung metastasis

| 1

USP51 activates lung metastasis. 1 / 1

| 1

➶

eidos

32195004

USP51 affects hypersensitivity

| 1

USP51 inhibits hypersensitivity. 1 / 1

| 1

➶

reach

"USP51 depletion leads to ionizing radiation hypersensitivity and dysregulated DNA repair [78]."

33797206

USP51 affects hispidulin TRAIL cells

| 1

USP51 activates hispidulin TRAIL cells. 1 / 1

| 1

➶

eidos

"Inhibition of USP51 partially blocked apoptosis by hispidulin plus TRAIL in Caki , A498 and DU145 cells ( Figure 6F ) ."

31817696

USP51 affects epithelial to mesenchymal transition

| 1

USP51 activates epithelial to mesenchymal transition. 1 / 1

| 1

➶

reach

"Collectively, the findings of this study shed light on a key mechanism by which elevated USP51 expression induces Epithelial-mesenchymal transition (EMT) in GC cells, hence facilitating GC cell proliferation, survival, and dissemination."

36603607

USP51 affects deubiquitination stabilization ZEB1.33

| 1

USP51 activates deubiquitination stabilization ZEB1.33. 1 / 1

| 1

➶

eidos

"USP51 deubiquitinates and stabilizes ZEB1 It was previously reported that USP51 , a deubiquitinase , could promote the deubiquitination and stabilization of ZEB1.33 Notably , we searched the PhosphoSitePlus ( R ) database and identified Ser26 as a major phosphorylation site on USP51 ( Supplementary Fig. S6a ) , which also matches the CDK consensus motif S / T-P ."

32195004

USP51 affects cleaved poly ADP-ribose polymerase

| 1

USP51 inhibits cleaved poly ADP-ribose polymerase. 1 / 1

| 1

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eidos

32468048

USP51 affects cleaved caspase-3

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USP51 inhibits cleaved caspase-3. 1 / 1

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32468048

USP51 affects cell cycle

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USP51 inhibits cell cycle. 1 / 1

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"Knockdown of USP51 decreases the cell proliferation and halts the cell cycle at G0/G1 phase."

32486158

USP51 affects cdk-4

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USP51 binds cdk-4. 1 / 1

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"CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB1."

35058607

USP51 affects cancer cell metastasis

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USP51 activates cancer cell metastasis. 1 / 1

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"USP51 regulates cancer metastasis through ZEB1 We next examined whether USP51 depletion could inhibit cancer cell metastasis through the regulation of ZEB1 ."

32195004

USP51 affects ZEB1 ubiquitination

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USP51 inhibits ZEB1 ubiquitination. 1 / 1

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"Lastly , knockdown of USP51 promoted ZEB1 ubiquitination , leading to ZEB1 degradation ."

32468048

USP51 affects ZEB1 protein

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USP51 activates ZEB1 protein. 1 / 1

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"Remarkably , USP51 depletion promoted ZEB1 protein degradation in response to treatment with CHX ( Fig. 2g ) ."

32195004

USP51 affects ZEB1 protein stability breast cancer cell lines

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USP51 activates ZEB1 protein stability breast cancer cell lines. 1 / 1

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"Among DUBs , ubiquitin specific peptidase 51 ( USP51 ) binds to the N-terminal of ZEB1 and increases ZEB1 protein stability in breast cancer cell lines [ 171 ] ."

33808323

USP51 affects USP28

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USP28 binds USP51. 1 / 1

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No evidence text available

22626734

USP51 affects USP21

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USP21 binds USP51. 1 / 1

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No evidence text available

22626734

USP51 affects USP15

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USP15 binds USP51. 1 / 1

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No evidence text available

22626734

USP51 affects TP53BP1

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USP51 leads to the deubiquitination of TP53BP1. 1 / 1

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"Overexpression of USP51 suppresses H2A ubiquitination as well as 53BP1 and BRCA1, but not RNF168 IRIF formation."

33797206

USP51 affects TIMM8A

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USP51 activates TIMM8A. 1 / 1

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"Collectively, the present findings demonstrated that USP51 inhibition attenuated DDP resistance in A549 and DDP cells via ubiquitin mediated degradation of ZEB1."

32468048

USP51 affects Stomach Neoplasms

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USP51 activates Stomach Neoplasms. 1 / 1

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36603607

USP51 affects Radiation, Ionizing

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USP51 activates Radiation, Ionizing. 1 / 1

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"Interestingly, USP51 overexpression also increases sensitivity to IR, suggesting DSB repair needs to be maintained in a delicate balance."

32708614

USP51 affects RNF169

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USP51 inhibits RNF169. 1 / 1

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"Conversely, USP51 overexpression does lead to reduced RNF169, 53BP1, and BRCA1 foci, all of which are recruited to RNF168 targets."

32708614

USP51 affects PJA1

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PJA1 binds USP51. 1 / 1

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No evidence text available

22626734

USP51 affects NHEJ repair efficiency

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USP51 activates NHEJ repair efficiency. 1 / 1

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eidos

34188037

USP51 affects NHEJ efficiency LM2-DRR cells

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USP51 activates NHEJ efficiency LM2-DRR cells. 1 / 1

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"e Knockdown of USP51 decreased HR and NHEJ efficiency in LM2-DRR cells ."

34188037

USP51 affects Histone

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USP51 activates Histone. 1 / 1

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"Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones."

30192049

USP51 affects His2A

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USP51 binds His2A. 1 / 1

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"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15 ub."

27083998

USP51 affects H2Bub1

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USP51 activates H2Bub1. 1 / 1

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"Taken together with previous findings by others that USP22 is overexpressed in many cancers and our findings that ATXN7L3 and ENY2 levels are normally limiting in cells, these results suggest that imb[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

27132940

USP51 affects H2BK120Ub

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USP51 deubiquitinates H2BK120Ub. 1 / 1

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"Further experiments established that USP51 in vitro could deubiquitinate a nucleosome carrying H2BK120Ub, but not H2BK34Ub."

30192049

USP51 affects H2BC10

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USP51 deubiquitinates H2BC10. 1 / 1

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"In contrast, depletion of non-enzymatic components, ATXN7L3 or ENY2, results in increased H2Bub1. These observations led us to discover two H2Bub1 DUBs, USP27X and USP51, which function independently of SAGA and compete with USP22 for ATXN7L3 and ENY2 for activity."

27132940

USP51 affects H2AX

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USP51 deubiquitinates H2AX. 1 / 1

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"USP3, USP51 and USP16 de-ubiquitinate H2A/H2AX with varying degrees of specificity [47–49]."

31769469

USP51 affects DNA repair

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USP51 inhibits DNA repair. 1 / 1

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"USP51 depletion leads to ionizing radiation hypersensitivity and dysregulated DNA repair [78]."

33797206

USP51 affects DDP resistance A549

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USP51 activates DDP resistance A549. 1 / 1

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"Collectively , the present findings demonstrated that USP51 inhibition attenuated DDP resistance in A549 / DDP cells via ubiquitin-mediated degradation of ZEB1 ."

32468048

USP51 affects Cebpb

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USP51 binds Cebpb. 1 / 1

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34188037

USP51 affects CHEK1

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USP51 leads to the phosphorylation of CHEK1. 1 / 1

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"USP51 overexpression in lung cancer cells in vitro reduced γ-H2AX formation and promoted CHK1 phosphorylation, whereas USP51 knockdown showed opposite effects, indicating that USP51 played an important role in promoting DNA damage repair."

35856403

USP51 affects CDK

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CDK binds USP51 and USP17L2. 1 / 1

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34204543

USP51 affects CD274

| 1

USP51 ubiquitinates CD274. 1 / 1

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"Of note, we identified that a flavonoid compound dihydromyricetin (DHM) acted as a potential USP51 inhibitor and rendered NSCLC cells more sensitive to chemotherapy by targeting USP51-dependent PD-L1 ubiquitination and degradation in vitro and in vivo."

37386737