IndraLab

Statements

reach
"In the cisplatin-resistant lung cancer cell line A549/DDP, USP51 knockdown significantly induces apoptosis and the ubiquitin-mediated degradation of ZEB1, whereas overexpression of USP51 decreases the cleavage of PARP-1 and caspase-3."
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reach
"The cell viability (Supplementary Figure S20C), colony formation (Supplementary Figure S20D), cell apoptosis (Supplementary Figure S20E‐F), and DNA damage detection assays (Supplementary Figure S20G‐H) further confirmed that overexpression of USP51 strongly reduced cell proliferation retardation and cell apoptosis but promoted DNA damage repair in response to DDP; however, USP51‐induced chemoresistant phenotypes were weakened by the addition of DHM."
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