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USP51 deubiquitinates ZEB1. 9 / 10
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"Additionally, USP51 can interact with ZEB1, and the reduction of USP51 levels increases ZEB1 ubiquitination, significantly lowering cisplatin resistance in lung cancer cells [46]."
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"They found that CDK4/6 phosphorylate and activate the deubiquitinase USP51, which is necessary for ZEB1 deubiquitination and stabilization."
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"Consistently, USP51 deubiquitinates ZEB1 resulting in a poor prognosis in breast cancer patients [241]."
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"USP51 promotes deubiquitination and stabilization of ZEB1."
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"In addition, USP51 deubiquitinates and stabilizes the ZEB1 protein."
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"For example, USP51 promotes the deubiquitylation and stabilization of ZEB1 in breast cancer cells [40], PRMT1 activates the transcription of ZEB1 by mediating dimethylation at arginine 3 of histone H4 (H4R3me2) [41], and the DNA methyltransferase inhibitor 5-Aza-2’-deoxycytidine can effectively restore the expression of ZEB1 target genes [42]."
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"USP51, as a deubiquitinating enzyme, promotes the proliferation and invasion of endometrial cancer cells [48] and the deubiquitination and stabilization of ZEB1 in breast cancer cells [49] ."
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"Lastly, knockdown of USP51 promoted ZEB1 ubiquitination, leading to ZEB1 degradation."
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"However, deubiquitination of ZEB1 by the ubiquitin-specific protease-51 (USP51) promotes its stabilization [96] ."
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