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USP51 activates ZEB1. 5 / 5
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"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."
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"In addition , knockdown of USP51 in A549 / DDP cells significantly induced apoptosis , decreased ZEB1 expression and increased cleaved poly ADP-ribose polymerase 1 ( PARP1 ) and cleaved caspase-3 levels ."
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"Among DUBs, ubiquitin specific peptidase 51 (USP51) binds to the N-terminal of ZEB1 and increases ZEB1 protein stability in breast cancer cell lines [XREF_BIBR]."
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"Thus , the deubiquitinases ( DUBs ) were involved in counteracting polyubiquitination and proteasomal degradation of ZEB1 [ 40 ] ; these DUBs include USP51 , which upregulated ZEB1 and the mesenchymal markers by binding , deubiquitinating , and stabilizing ZEB1 [ 41 ] ."
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"Conversely, overexpression of USP51 in epithelial cells resulted in upregulation of ZEB1 and mesenchymal markers."
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