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USP51 activates Neoplasms. 6 / 6
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"Finally, USP51 knockdown weakened cisplatin resistance in A549/DDP cells and significantly suppressed tumor growth in vivo, suggesting that a USP51 inhibitor combined with cisplatin may be considered as an effective treatment strategy to eliminate drug-resistant lung cancer cells."
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"In line, using BALB/c nude mice xenograft model, we confirmed that USP51 knockdown severely inhibited tumor growth upon DDP treatment, which was suppressed in mice with PD‐L1‐harboring tumors (Figure 4L‐M)."
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"The results of loss-of-function studies suggested that USP51 knockdown reduced the expression of stemness markers in NSCLC cells, thereby diminishing the growth and tumor sphere formation of NSCLC cells."
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"Since the above results have shown that USP51 overexpression promotes the transformation of tumors to a mesenchymal-like phenotype, pathological sections directly confirmed that samples with high USP5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These findings suggested that increased activation of USP51 signaling could increase the chance of tumor immune escape and resistance to immunotherapy in GC patients.Gastric cancer (GC) is considered [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, we showed that USP51 promotes tumor metastasis and invasion through regulating ZEB1, which is a key transcriptional factor that induces the malignant progression of lung adenocarcinoma."
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