IndraLab

Statements

USP51 binds ELOC. 7 / 7
4 | 3
reach
"Mechanically, USP51 directly binds to Elongin C (ELOC) and forms a larger functional complex with VHL E3 ligase (USP51/VHL/CUL2/ELOB/ELOC/RBX1) to regulate the ubiquitin-dependent proteasomal degradation of HIF1A."
37816999
reach
"The deSUMOylation of ELOC induced by SENP1 promoted USP51 bind to ELOC and facilitated the deubiquitylation and stabilization of HIF-1α, consequently enhancing colorectal cancer cells stemness (Mu et al., 2023)."
38389923
reach
"SUMO-specific protease 1 (SENP1) mediates the deSUMOylation of ELOC, promoting the binding of USP51 to ELOC and facilitating the deubiquitination and stabilization of HIF1A by USP51."
37816999
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999
biogrid
No evidence text available
37816999