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USP51 leads to the phosphorylation of CHEK1. 2 / 2

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"USP51 overexpression in lung cancer cells in vitro reduced γ-H2AX formation and promoted CHK1 phosphorylation, whereas USP51 knockdown showed opposite effects, indicating that USP51 played an important role in promoting DNA damage repair."

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"In lung cancer patients with cisplatin resistance, the upregulation of USP51 diminishes γH2AX formation and increases checkpoint kinase 1 (CHK1) phosphorylation, thereby ensuring an effective cell cycle [29]."

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IndraLab

Statements

USP51 leads to the phosphorylation of CHEK1. 2 / 2

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