IndraLab

Statements

USP51 binds ZEB1. 16 / 16
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"Rather, the co-IP assay demonstrated that USP51 interacted with ZEB1 in A549/DDP cells ( xref ), and that USP51 knockdown promoted the ubiquitination and degradation of the ZEB1 protein ( xref )."
32468048
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"By contrast, ubiquitin-specific peptidase 51 (USP51) binds to ZEB1 and promotes its ubiquitination and stability, thus supporting invasion by breast cancer cells [ 96 ]."
37328395
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"USP51 interacted with ZEB1, and knockdown of USP51 markedly induced ubiquitin-mediated degradation of ZEB1."
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"Additionally, co-immunoprecipitation assays indicated a physical interaction between USP51 and ZEB1 under sparse conditions (Supplementary Fig. xref ), suggesting that USP51 directly interacted with and deubiquitinated ZEB1 protein."
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"Additionally, USP51 can interact with ZEB1, and the reduction of USP51 levels increases ZEB1 ubiquitination, significantly lowering cisplatin resistance in lung cancer cells [ xref ]."
38702734
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"Over-expression of CDK6 causes the hyperphosphorylation of USP51 protein, causing its structural alteration and functional inactivation, and hence, USP51 protein cannot interact with ZEB1 protein [105[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 5 L-M, there was a strong positive correlation between USP51, ZEB1, and ACTA2 at the protein level (USP51-ZEB1, r = 0.652, P < 0.001; ACTA2-ZEB1, r = 0.563, P < 0.001)."
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29119051
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29119051
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32468048
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"Our finding of deubiquitination of ZEB1 by USP10 resulting in its proteasomal degradation is mechanistically distinct from the reported interaction of ZEB1 with USP51 resulting in its deubiquitination and stabilization ( xref )."
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