IndraLab

Statements

USP51 activates TIMM8A. 2 / 2
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"Collectively, the present findings demonstrated that USP51 inhibition attenuated DDP resistance in A549 and DDP cells via ubiquitin mediated degradation of ZEB1."
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"The cell viability (Supplementary Figure S20C), colony formation (Supplementary Figure S20D), cell apoptosis (Supplementary Figure S20E‐F), and DNA damage detection assays (Supplementary Figure S20G‐H) further confirmed that overexpression of USP51 strongly reduced cell proliferation retardation and cell apoptosis but promoted DNA damage repair in response to DDP; however, USP51‐induced chemoresistant phenotypes were weakened by the addition of DHM."
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