IndraLab

Statements

USP51 binds H2AC20. 6 / 6
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biogrid
No evidence text available
27083998
biogrid
No evidence text available
27083998
sparser
"To test whether USP51 is an H2AK13,15ub DUB, we first tested whether USP51 can bind to histone H2A. Purified His-tagged USP51 was used to pull down recombinant H2A–H2B dimers in vitro."
27083998
sparser
"His-USP51 bound to H2A, but His-tagged Asf1, a histone H3–H4 chaperone, did not ( xref A), suggesting that USP51 bound to H2A in vitro."
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sparser
"Third, USP51 interacts with H2A and removes H2AK15ub but not H2AK119ub in vitro."
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sparser
"USP51 binds to H2A and deubiquitylates H2AK13,15ub in vitro."
27083998