IndraLab

Statements

USP51 is phosphorylated. 4 / 4
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"Notably, the high expression of p -RB, p -USP51, and ZEB1 was significantly correlated with a poor clinical outcome."
32195004
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"Moreover, we found a strong positive correlation between the expression of p -RB (an indicator of CDK4/6 activity), p -USP51 and ZEB1 in metastatic human breast cancer samples."
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"In terms of molecular mechanism, USP51 is phosphorylated and activated by CDK4/6, thus resulting in the deubiquitination and stabilization of ZEB1 protein."
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"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
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