IndraLab

Statements

OTUD7A affects UBC
9 1 |
OTUD7A deubiquitinates UBC.
9 |
OTUD7A deubiquitinates UBC on K239. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K391. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K543. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K11. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K163. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K87. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K619. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K315. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBC on K467. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A binds UBC.
1 |
UBC binds OTUD7A. 1 / 1
1 |
biogrid
No evidence text available
23827681
OTUD7A affects Sarcoma, Ewing
| 5
OTUD7A activates Sarcoma, Ewing.
| 3
reach
"These data support OTUD7A as a possible EWS–FLI1 deubiquitinating enzyme to control EWS–FLI1 protein stability.2.4 Genetic Depletion of OTUD7A Impedes Ewing Sarcoma Growth."
34060252
reach
"Using artificial‐intelligence (AI)‐aided virtual drug screening, we identify the first OTUD7A catalytic inhibitor, which limits Ewing sarcoma growth in vitro and in mice by degrading EWS–FLI1.The FLI1 domain in EWS–FLI1 is targeted by SPOP and OTUD7A."
34060252
reach
"These data support that changes in EWS–FLI1 following OTUD7A depletion affect a subset of EWS–FLI1 transcriptional targets.2.7 Quantitative Proteomics Identifies OTUD7A Downstream Targets Mediating Ewing Sarcoma Cell Migration."
34060252
OTUD7A inhibits Sarcoma, Ewing.
| 2
reach
"Depletion of OTUD7A in Ewing sarcoma cell lines reduces EWS-FLI1 protein abundance and impedes Ewing sarcoma growth in vitro and in mice."
34060252
reach
"In further support of the inactivation of OTUD7A impeding Ewing sarcoma proliferation, depletion of OTUD7A resulted in significantly reduced colony formation in vitro in A673 but not A673 cells (Figure 3J,K)."
34060252
TRAF6 affects OTUD7A
1 | 1 1
TRAF6 binds OTUD7A. 3 / 4
1 | 1 1
reach
"They indicated that Cezanne2 interacted with TRAF6 and cleaved the polyubiquitin from TRAF6 substrates whose suppression might have a key role in the HCC malignancy transformation [XREF_BIBR]."
27708550
biogrid
No evidence text available
23792447
sparser
"They indicated that Cezanne2 interacted with TRAF6 and cleaved the polyubiquitin from TRAF6 substrates whose suppression might have a key role in the HCC malignancy transformation [ xref ]."
27708550
reach
"In further support of the inactivation of OTUD7A impeding Ewing sarcoma proliferation, depletion of OTUD7A resulted in significantly reduced colony formation in vitro in A673 but not A673 cells (Figure 3J,K)."
34060252
reach
"Like genetic OTUD7A depletion, pharmacological inhibition of OTUD7A by the compound 7Ai also decreased proliferation of Jurkat cells (Figure S20F, Supporting Information)."
34060252
reach
"Importantly, for all Ewing sarcoma cell lines tested, OTUD7A depletion reduced cell proliferation in vitro (Figure 3D–F)."
34060252
OTUD7A affects TRAF6
1 | 1 1
TRAF6 binds OTUD7A. 3 / 4
1 | 1 1
reach
"They indicated that Cezanne2 interacted with TRAF6 and cleaved the polyubiquitin from TRAF6 substrates whose suppression might have a key role in the HCC malignancy transformation [XREF_BIBR]."
27708550
biogrid
No evidence text available
23792447
sparser
"They indicated that Cezanne2 interacted with TRAF6 and cleaved the polyubiquitin from TRAF6 substrates whose suppression might have a key role in the HCC malignancy transformation [ xref ]."
27708550
OTUD7A affects FLI1
| 4
OTUD7A activates FLI1.
| 2
OTUD7A activates FLI1. 2 / 2
| 2
reach
"Remarkably, induced depletion of OTUD7A led to reduced EWS–FLI1 protein levels in multiple Ewing sarcoma cells, including A673 (Figure 3D), MHH‐ES‐1 (Figure 3E), and EWS894 (Figure 3F)."
34060252
reach
"These data suggest that OTUD7A/EWS–FLI1 signaling modulates a subset of EWS–FLI1 targets.In addition to characterized EWS–FLI1 target proteins whose protein abundance was controlled by OTUD7A (Figure 4D), there were additional 572 proteins downregulated by OTUD7A genetic depletion (Table S3, Supporting Information), suggesting they are potential targets for OTUD7A or uncharacterized EWS–FLI1 targets."
34060252
OTUD7A deubiquitinates FLI1.
| 1
OTUD7A deubiquitinates FLI1. 1 / 1
| 1
reach
"Consistently, both OTUD3 and OTUD7A could deubiquitinate EWS–FLI1 in cells (Figure 3C and Figure S8D,E (Supporting Information))."
34060252
OTUD7A decreases the amount of FLI1.
| 1
OTUD7A decreases the amount of FLI1. 1 / 1
| 1
reach
"MG132 treatment largely preserved EWS–FLI1 protein levels following OTUD7A depletion (Figure S9C–E, Supporting Information), further supporting a role of OTUD7A in regulating EWS–FLI1 protein stability."
34060252
Polyubiquitin affects OTUD7A
| 2 1
reach
"They indicated that Cezanne2 interacted with TRAF6 and cleaved the polyubiquitin from TRAF6 substrates whose suppression might have a key role in the HCC malignancy transformation [XREF_BIBR]."
27708550
reach
"Co-immunoprecipitation and in vivo deubiquitination assay indicated that Cezanne2 interacts with TNF receptor associated factor (TRAF) 6 and cleaves the polyubiquitin from TRAF6 substrates."
23792447
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
SNAI1 affects OTUD7A
| 3
SNAI1 binds OTUD7A. 3 / 3
| 3
sparser
"Here, we report that Cezanne2 expression is downregulated in HCC cells and in HCC patients' tumorous tissues and that Cezanne2 is inversely associated with Snail1 expression in HCC patients' tumorous tissues."
23792447
sparser
"However, MPND and Cezanne2 slightly interact with Snail1 after proteasome inhibition ( xref ) suggesting that accumulation of poly-ubiquitinated Snail1 might favor the association with these particular DUBs."
30341066
sparser
"Chromatin immunoprecipitation assays and the reporter gene assay showed that Snail1 binds to the promoter of the Cezanne2 gene and mediates the direct consequence of Cezanne2 repression."
23792447
OTUD7A affects polyubiquitin
| 2 1
reach
"They indicated that Cezanne2 interacted with TRAF6 and cleaved the polyubiquitin from TRAF6 substrates whose suppression might have a key role in the HCC malignancy transformation [XREF_BIBR]."
27708550
reach
"Co-immunoprecipitation and in vivo deubiquitination assay indicated that Cezanne2 interacts with TNF receptor associated factor (TRAF) 6 and cleaves the polyubiquitin from TRAF6 substrates."
23792447
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7A affects UBB
3 |
OTUD7A deubiquitinates UBB on K11. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBB on K163. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A deubiquitinates UBB on K87. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A affects SNAI1
| 3
SNAI1 binds OTUD7A. 3 / 3
| 3
sparser
"Here, we report that Cezanne2 expression is downregulated in HCC cells and in HCC patients' tumorous tissues and that Cezanne2 is inversely associated with Snail1 expression in HCC patients' tumorous tissues."
23792447
sparser
"However, MPND and Cezanne2 slightly interact with Snail1 after proteasome inhibition ( xref ) suggesting that accumulation of poly-ubiquitinated Snail1 might favor the association with these particular DUBs."
30341066
sparser
"Chromatin immunoprecipitation assays and the reporter gene assay showed that Snail1 binds to the promoter of the Cezanne2 gene and mediates the direct consequence of Cezanne2 repression."
23792447
OTUD7A affects Mice
| 3
OTUD7A activates Mice.
| 2
OTUD7A activates Mice. 2 / 2
| 2
reach
"Uddin and colleagues combined whole-genome sequencing, human brain gene expression analysis, and study of a mouse model with a syntenic heterozygous deletion of 15q13; they found reduced expression of OTUD7A in the dendritic spine of the cortical neurons that contributed to the dendrite outgrowth abnormalities in the heterozygous 15q13 deletion mice."
34659328
reach
"Using artificial‐intelligence (AI)‐aided virtual drug screening, we identify the first OTUD7A catalytic inhibitor, which limits Ewing sarcoma growth in vitro and in mice by degrading EWS–FLI1.The FLI1 domain in EWS–FLI1 is targeted by SPOP and OTUD7A."
34060252
OTUD7A inhibits Mice.
| 1
OTUD7A inhibits Mice. 1 / 1
| 1
reach
"Depletion of OTUD7A in Ewing sarcoma cell lines reduces EWS-FLI1 protein abundance and impedes Ewing sarcoma growth in vitro and in mice."
34060252
OTUD7A affects EWSR1
| 3
OTUD7A deubiquitinates EWSR1.
| 1
OTUD7A leads to the deubiquitination of EWSR1. 1 / 1
| 1
reach
"In addition, 7Ai efficiently blocked OTUD7A‐mediated deubiquitination of EWS–FLI1 in cells (Figure 5C and Figure S16E (Supporting Information))."
34060252
OTUD7A binds EWSR1.
| 1
OTUD7A binds EWSR1. 1 / 1
| 1
reach
"7Ai did not interfere with OTUD7A binding to EWS–FLI1 (Figure S16G, Supporting Information), suggesting this compound might suppress OTUD7A catalytic activity through interaction with the catalytic domain."
34060252
OTUD7A activates EWSR1.
| 1
OTUD7A activates EWSR1. 1 / 1
| 1
reach
"These data suggest that OTUD7A/EWS–FLI1 signaling modulates a subset of EWS–FLI1 targets.In addition to characterized EWS–FLI1 target proteins whose protein abundance was controlled by OTUD7A (Figure 4D), there were additional 572 proteins downregulated by OTUD7A genetic depletion (Table S3, Supporting Information), suggesting they are potential targets for OTUD7A or uncharacterized EWS–FLI1 targets."
34060252
Paracetamol affects OTUD7A
2 |
Paracetamol increases the amount of OTUD7A.
1 |
Paracetamol increases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
29067470
Paracetamol decreases the amount of OTUD7A.
1 |
Paracetamol decreases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
22230336
Bisphenol A affects OTUD7A
2 |
Bisphenol A decreases the amount of OTUD7A. 2 / 2
2 |
ctd
No evidence text available
25181051
ctd
No evidence text available
30816183
Snail1 affects OTUD7A
| 2
Snail1 inhibits OTUD7A. 2 / 2
| 2
reach
"Snail1 dependent transcriptional repression of Cezanne2 in hepatocellular carcinoma."
23792447
reach
"Chromatin immunoprecipitation assays and the reporter gene assay showed that Snail1 binds to the promoter of the Cezanne2 gene and mediates the direct consequence of Cezanne2 repression."
23792447
OTUD7B affects OTUD7A
| 1 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7B binds OTUD7A. 1 / 1
| 1
reach
"Cezanne2 interacts with Cezanne, facilitating Cezanne in the recruitment of Rap80 and BRCA1-A, Rad18, and 53BP1, in cellular resistance to ionizing radiation and DNA repair."
31699778
OTUD7A inhibits synapse organization. 2 / 2
| 2
reach
"These results suggest that OTUD7A LoF impairs synapse development and neuronal function in human neurons, providing mechanistic insight into the possible role of OTUD7A in driving neuropsychiatric phenotypes associated with the 15q13.3 deletion."
35931052
reach
"Loss of function of OTUD7A in the schizophrenia- associated 15q13.3 deletion impairs synapse development and function in human neurons."
35931052
OTUD7A affects cell migration
| 2
reach
"Intriguingly, OTUD7A depletion significantly reduced cell migration in vitro, in both A673 and A673 cells (Figure 4N,O and Figure S13C,D (Supporting Information))."
34060252
reach
"These data support that changes in EWS–FLI1 following OTUD7A depletion affect a subset of EWS–FLI1 transcriptional targets.2.7 Quantitative Proteomics Identifies OTUD7A Downstream Targets Mediating Ewing Sarcoma Cell Migration."
34060252
OTUD7A affects OTUD7B
| 1 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7B binds OTUD7A. 1 / 1
| 1
reach
"Cezanne2 interacts with Cezanne, facilitating Cezanne in the recruitment of Rap80 and BRCA1-A, Rad18, and 53BP1, in cellular resistance to ionizing radiation and DNA repair."
31699778
OTUD7A affects EWS-FLI1 protein
| 2
OTUD7A inhibits EWS-FLI1 protein.
| 1
OTUD7A inhibits EWS-FLI1 protein. 1 / 1
| 1
reach
"Depletion of OTUD7A in Ewing sarcoma cell lines reduces EWS-FLI1 protein abundance and impedes Ewing sarcoma growth in vitro and in mice."
34060252
OTUD7A activates EWS-FLI1 protein.
| 1
OTUD7A activates EWS-FLI1 protein. 1 / 1
| 1
reach
"Depletion of OTUD7A in Ewing sarcoma cell lines reduces EWS-FLI1 protein abundance and impedes Ewing sarcoma growth in vitro and in mice."
34060252
OTUD7A affects Ankyrin-G-270
| 2
OTUD7A increases the amount of Ankyrin-G-270. 1 / 1
| 1
reach
"Expression of OTUD7A N492_K494del or OTUD7A L233F was able to increase levels of Ankyrin-G-270 but did not increase levels of Ankyrin-G-190 (Fig. 7e–g), suggesting that patient mutations may specifically affect the ability of OTUD7A to regulate the 190 kDa isoform of Ankyrin-G-190."
36604605
OTUD7A-L233F increases the amount of Ankyrin-G-270. 1 / 1
| 1
reach
"Expression of OTUD7A N492_K494del or OTUD7A L233F was able to increase levels of Ankyrin-G-270 but did not increase levels of Ankyrin-G-190 (Fig. 7e–g), suggesting that patient mutations may specifically affect the ability of OTUD7A to regulate the 190 kDa isoform of Ankyrin-G-190."
36604605
OTUD7A affects Ankyrin-G-190
| 2
OTUD7A-L233F increases the amount of Ankyrin-G-190. 1 / 1
| 1
reach
"Expression of OTUD7A N492_K494del or OTUD7A L233F was able to increase levels of Ankyrin-G-270 but did not increase levels of Ankyrin-G-190 (Fig. 7e–g), suggesting that patient mutations may specifically affect the ability of OTUD7A to regulate the 190 kDa isoform of Ankyrin-G-190."
36604605
OTUD7A increases the amount of Ankyrin-G-190. 1 / 1
| 1
reach
"Expression of OTUD7A N492_K494del or OTUD7A L233F was able to increase levels of Ankyrin-G-270 but did not increase levels of Ankyrin-G-190 (Fig. 7e–g), suggesting that patient mutations may specifically affect the ability of OTUD7A to regulate the 190 kDa isoform of Ankyrin-G-190."
36604605
EWSR1 affects OTUD7A
| 2
EWSR1 binds OTUD7A.
| 1
OTUD7A binds EWSR1. 1 / 1
| 1
reach
"7Ai did not interfere with OTUD7A binding to EWS–FLI1 (Figure S16G, Supporting Information), suggesting this compound might suppress OTUD7A catalytic activity through interaction with the catalytic domain."
34060252
EWSR1 activates OTUD7A.
| 1
EWSR1 activates OTUD7A. 1 / 1
| 1
reach
"To further reinforce this notion, we also expressed EWS–FLI1‐3A in both EWS894‐teton‐shOTUD7A (Figure S11L,M, Supporting Information) and MHH‐ES‐1‐teton‐shOTUD7A cells (Figure S11O,P, Supporting Information) and found that EWS–FLI1‐3A largely rescued OTUD7A‐depletion‐induced growth retardation in both cell lines (Figure S11N,Q, Supporting Information)."
34060252
Valproic acid affects OTUD7A
1 |
Valproic acid methylates OTUD7A. 1 / 1
1 |
ctd
No evidence text available
29154799
Triclosan affects OTUD7A
1 |
Triclosan increases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
30510588
Titanium dioxide affects OTUD7A
1 |
Titanium dioxide decreases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
30012374
Sulforaphane affects OTUD7A
1 |
Sulforaphane decreases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
31838189
Polyubiquitin affects UBA1
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
Methyltestosterone decreases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
29191790
Methapyrilene affects OTUD7A
1 |
Methapyrilene methylates OTUD7A. 1 / 1
1 |
ctd
No evidence text available
30157460
Hsa-miR-8080 affects OTUD7A
1 |
Hsa-miR-8080 decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7-2-3p affects OTUD7A
1 |
Hsa-miR-7-2-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-7-1-3p affects OTUD7A
1 |
Hsa-miR-7-1-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-670-3p affects OTUD7A
1 |
Hsa-miR-670-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-642b-3p affects OTUD7A
1 |
Hsa-miR-642b-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-642a-3p affects OTUD7A
1 |
Hsa-miR-642a-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5582-3p affects OTUD7A
1 |
Hsa-miR-5582-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548x-5p affects OTUD7A
1 |
Hsa-miR-548x-5p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548o-3p affects OTUD7A
1 |
Hsa-miR-548o-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548g-5p affects OTUD7A
1 |
Hsa-miR-548g-5p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548f-5p affects OTUD7A
1 |
Hsa-miR-548f-5p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548aw affects OTUD7A
1 |
Hsa-miR-548aw decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-548aj-5p affects OTUD7A
1 |
Hsa-miR-548aj-5p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-491-3p affects OTUD7A
1 |
Hsa-miR-491-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-30c-5p affects OTUD7A
1 |
Hsa-miR-30c-5p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-153-5p affects OTUD7A
1 |
Hsa-miR-153-5p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-1468-3p affects OTUD7A
1 |
Hsa-miR-1468-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-1323 affects OTUD7A
1 |
Hsa-miR-1323 decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-1255b-2-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-1238-3p affects OTUD7A
1 |
Hsa-miR-1238-3p decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-1197 affects OTUD7A
1 |
Hsa-miR-1197 decreases the amount of OTUD7A. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Gentamycin affects OTUD7A
1 |
Gentamycin decreases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
22061828
Benzo[e]pyrene affects OTUD7A
1 |
Benzo[e]pyrene methylates OTUD7A. 1 / 1
1 |
ctd
No evidence text available
30157460
Aflatoxin B2 affects OTUD7A
1 |
Aflatoxin B2 methylates OTUD7A. 1 / 1
1 |
ctd
No evidence text available
30157460
Acrylamide affects OTUD7A
1 |
Acrylamide increases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
28959563
UBC affects OTUD7A
1 |
UBC binds OTUD7A. 1 / 1
1 |
biogrid
No evidence text available
23827681
UBA1 affects polyubiquitin
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
trips
"Co-immunoprecipitation and in vivo deubiquitination assay indicated that Cezanne2 interacts with TNF receptor-associated factor (TRAF)6 and cleaves the polyubiquitin from TRAF6 substrates."
23792447
TNF receptor affects OTUD7A
| 1
OTUD7A binds TNF receptor. 1 / 1
| 1
reach
"Co-immunoprecipitation and in vivo deubiquitination assay indicated that Cezanne2 interacts with TNF receptor associated factor (TRAF) 6 and cleaves the polyubiquitin from TRAF6 substrates."
23792447
Sesame Oil affects OTUD7A
1 |
Sesame Oil increases the amount of OTUD7A. 1 / 1
1 |
ctd
No evidence text available
29191790
Sarcoma, Ewing affects OTUD7A
| 1
reach
"These results motivated us to search for potential small molecules that would inhibit OTUD7A catalytic activity as a possible therapeutic strategy for Ewing sarcoma.2.8 OTUD7A is Expressed across Tissues, Including Ewing Sarcoma Tumors."
34060252
REPIN1 affects OTUD7A
1 |
REPIN1 decreases the amount of OTUD7A. 1 / 1
1 |
biopax:msigdb
No evidence text available
OTUD7B affects polyubiquitin
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
reach
"Given our data supporting the importance of the OTUD7A/Ankyrin-G interaction in 15q13.3 microdeletion neuronal phenotypes, as well as the observed changes in Ankyrin-G levels and stability in 15q13.3 microdeletion models, we examined whether re-expression of OTUD7A in Df(h15q13)/+ cortical neurons is sufficient to increase Ankyrin-G levels and rescue the protein homeostasis defects."
36604605
reach
"Sholl analysis revealed that re-expression of OTUD7A in 15q13.3 microdeletion iNeurons increased dendrite arborization back to familial control levels, indicating that re-expression of OTUD7A is sufficient to rescue morphological defects in human 15q13.3 microdeletion glutamatergic neurons (Fig. 7b, c)."
36604605
OTUD7A affects cell growth
| 1
OTUD7A activates cell growth. 1 / 1
| 1
reach
"As predicted, reconstitution of FLI1‐3A expression in A673‐teton‐shOTUD7A cells (Figure S11G,H, Supporting Information) could not rescue OTUD7A‐depletion‐induced A673 cell growth retardation in vitro (Figure S11I–K, Supporting Information)."
34060252
OTUD7A affects cell death
| 1
OTUD7A inhibits cell death. 1 / 1
| 1
reach
"Stable OTUD7A depletion led to cell death within a week of shRNA or sgRNA infection, preventing us from further analyzing the signaling changes and biological effects of OTUD7A loss."
34060252
OTUD7A affects UBA52
1 |
OTUD7A deubiquitinates UBA52 on K11. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A affects UBA1
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
trips
"Co-immunoprecipitation and in vivo deubiquitination assay indicated that Cezanne2 interacts with TNF receptor-associated factor (TRAF)6 and cleaves the polyubiquitin from TRAF6 substrates."
23792447
OTUD7A affects TNF receptor
| 1
OTUD7A binds TNF receptor. 1 / 1
| 1
reach
"Co-immunoprecipitation and in vivo deubiquitination assay indicated that Cezanne2 interacts with TNF receptor associated factor (TRAF) 6 and cleaves the polyubiquitin from TRAF6 substrates."
23792447
OTUD7A affects SPOP
| 1
OTUD7A inhibits SPOP. 1 / 1
| 1
reach
"The deubiquitinase OTUD7A antagonizes SPOP function to stabilize EWS–FLI1, revealing OTUD7A as a new Ewing‐sarcoma‐growth‐dependent gene."
34060252
OTUD7A affects SOX2
| 1
OTUD7A ubiquitinates SOX2. 1 / 1
| 1
sparser
"ShRNA targeting OTUD7B but not OTUD7A increased Sox2 ubiquitylation (Fig.  xref )."
30405104
OTUD7A affects RPS27A
1 |
OTUD7A deubiquitinates RPS27A on K11. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD7A affects OTUD7B, UBA1, and polyubiquitin
| 1
UBA1 binds OTUD7B, OTUD7A, and polyubiquitin. 1 / 1
| 1
sparser
"Using a ubiquitin binding domain protein array screen, we identify that the UBA domains of Cezanne and Cezanne2 (also known as Otud7A) selectively bind to Lys63-linked polyubiquitin."
31699778
OTUD7A affects OTUD6B
| 1
OTUD7A binds OTUD6B. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD7A affects OTUD4
| 1
OTUD7A binds OTUD4. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD7A affects OTUD3
| 1
OTUD7A binds OTUD3. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD7A activates Nervous System Diseases. 1 / 1
| 1
reach
"52 Although it remains unclear if these neurological disorders caused by OTUD7A dysfunction are limited to changes in dendritic spines, these results offer additional considerations if 7Ai or other OTUD7A inhibitors begin preclinical evaluation for Ewing sarcoma.Our studies demonstrated efficacy of 7Ai in vivo and in vitro efficacy in the micromolar range."
34060252
OTUD7A affects Neoplasms
| 1
OTUD7A activates Neoplasms. 1 / 1
| 1
reach
"Moreover, depletion of OTUD7A dramatically reduced tumor growth (Figure 3L) and tumor formation of A673 (Figure 3M,N), but not A673 (Figure S10A–C, Supporting Information) cells grown as xenografts."
34060252
OTUD7A affects Glu-Ser
| 1
OTUD7A activates Glu-Ser. 1 / 1
| 1
reach
"Remarkably, induced depletion of OTUD7A led to reduced EWS–FLI1 protein levels in multiple Ewing sarcoma cells, including A673 (Figure 3D), MHH‐ES‐1 (Figure 3E), and EWS894 (Figure 3F)."
34060252
OTUD7A affects EWS894
| 1
OTUD7A inhibits EWS894. 1 / 1
| 1
reach
"Remarkably, induced depletion of OTUD7A led to reduced EWS–FLI1 protein levels in multiple Ewing sarcoma cells, including A673 (Figure 3D), MHH‐ES‐1 (Figure 3E), and EWS894 (Figure 3F)."
34060252
OTUD7A affects EWS-FLI1
| 1
OTUD7A deubiquitinates EWS-FLI1. 1 / 1
| 1
reach
"Opposing this process, OTUD7A deubiquitinates and stabilizes EWS-FLI1."
34060252
OTUD7A affects EWS-FLI1 Transcriptional Targets
| 1
OTUD7A decreases the amount of EWS-FLI1 Transcriptional Targets. 1 / 1
| 1
reach
"Consistent with EWS–FLI1 signaling being a major OTUD7A downstream effector, more than one tenth (62) of the downregulated proteins exert DNA‐binding transcriptional activity (Figure S12D, Supporting Information), many of which have been characterized to associate with EWS–FLI1 on chromatin, including CBP, forkhead box proteins, and zinc finger proteins.2.6 Genetic OTUD7A Inactivation Reduces Expression of EWS-FLI1 Transcriptional Targets."
34060252
OTUD7A affects EGFR
| 1
OTUD7A activates EGFR. 1 / 1
| 1
reach
"Accordingly, simultaneous knockdown of Cezanne-1 and Cezanne-2 by using two pools of four oligonucleotides (approximately 70% and 50%, respectively) moderately enhanced both basal and inducible degradation of EGFR, whereas the reciprocal silencing of c-CBL and CBL-b showed the expected opposite effect (XREF_FIG)."
22179831
OTUD7A affects Circulin-C
| 1
OTUD7A binds Circulin-C. 1 / 1
| 1
sparser
"Circ-OTUD7A is highly expressed in DLBCL, and knockdown of circ-OTUD7A inhibits DLBCL cell proliferation and metastasis, promoting cell cycle arrest and apoptosis."
35116058
OTUD7A affects CHRNA7
| 1
OTUD7A activates CHRNA7. 1 / 1
| 1
reach
"We previously demonstrated that re-expression of OTUD7A in vivo rescues dendritic growth defects in mouse cortical neurons [30], whereas another study stimulated CHRNA7 using an alpha7 positive allosteric modulator [100]."
36604605
OTUD7A affects CFD
| 1
OTUD7A activates CFD. 1 / 1
| 1
reach
"Sholl analysis revealed that WT OTUD7A rescued dendrite complexity in Df(h15q13)/+ neurons, whereas OTUD7A L233F did not, indicating that the OTUD7A L233F variant affects the ability of OTUD7A to regulate dendrite complexity (Fig. 2e–g)."
36604605
OTUD7A affects ANK3
| 1
OTUD7A binds ANK3. 1 / 1
| 1
reach
"The interactions between OTUD7A and Ankyrin-G (Ank3) and Ankyrin-B (Ank2) were disrupted by an epilepsy-associated OTUD7A L233F variant."
36604605
OTUD7A affects ANK2
| 1
OTUD7A binds ANK2. 1 / 1
| 1
reach
"The interactions between OTUD7A and Ankyrin-G (Ank3) and Ankyrin-B (Ank2) were disrupted by an epilepsy-associated OTUD7A L233F variant."
36604605
OTUD7A affects 3A
| 1
OTUD7A increases the amount of 3A. 1 / 1
| 1
reach
"As a result, unlike WT‐EWS–FLI1, OTUD7A depletion failed to significantly impede 3A‐EWS–FLI1 expressing A673 cell growth in vitro (Figure S11C,D, Supporting Information) and as a xenograft (Figure S11E,F, Supporting Information)."
34060252
OTUD6B affects OTUD7A
| 1
OTUD7A binds OTUD6B. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD4 affects OTUD7A
| 1
OTUD7A binds OTUD4. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
OTUD3 affects OTUD7A
| 1
OTUD7A binds OTUD3. 1 / 1
| 1
reach
"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."
34060252
Neoplasms affects OTUD7A
| 1
Neoplasms inhibits OTUD7A. 1 / 1
| 1
reach
"These results motivated us to search for potential small molecules that would inhibit OTUD7A catalytic activity as a possible therapeutic strategy for Ewing sarcoma.2.8 OTUD7A is Expressed across Tissues, Including Ewing Sarcoma Tumors."
34060252
FLI1 affects OTUD7A
| 1
FLI1 inhibits OTUD7A. 1 / 1
| 1
reach
"These data support OTUD7A as a possible EWS–FLI1 deubiquitinating enzyme to control EWS–FLI1 protein stability.2.4 Genetic Depletion of OTUD7A Impedes Ewing Sarcoma Growth."
34060252
Circulin-C affects OTUD7A
| 1
OTUD7A binds Circulin-C. 1 / 1
| 1
sparser
"Circ-OTUD7A is highly expressed in DLBCL, and knockdown of circ-OTUD7A inhibits DLBCL cell proliferation and metastasis, promoting cell cycle arrest and apoptosis."
35116058
ARHGAP11B affects CHRNA7, FAN1, KLF13, OTUD7A, and TRPM1
| 1
sparser
"Our data support associations of schizophrenia with 1.5-Mb deletions containing ARHGAP11B, MTMR15, MTMR10, TRPM1, KLF13, OTUD7A, and CHRNA7."
21285140
ANK3 affects OTUD7A
| 1
OTUD7A binds ANK3. 1 / 1
| 1
reach
"The interactions between OTUD7A and Ankyrin-G (Ank3) and Ankyrin-B (Ank2) were disrupted by an epilepsy-associated OTUD7A L233F variant."
36604605
ANK2 affects OTUD7A
| 1
OTUD7A binds ANK2. 1 / 1
| 1
reach
"The interactions between OTUD7A and Ankyrin-G (Ank3) and Ankyrin-B (Ank2) were disrupted by an epilepsy-associated OTUD7A L233F variant."
36604605