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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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OTUD7A activates Sarcoma, Ewing. 3 / 3

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"These data support OTUD7A as a possible EWS–FLI1 deubiquitinating enzyme to control EWS–FLI1 protein stability.2.4 Genetic Depletion of OTUD7A Impedes Ewing Sarcoma Growth."

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"Using artificial‐intelligence (AI)‐aided virtual drug screening, we identify the first OTUD7A catalytic inhibitor, which limits Ewing sarcoma growth in vitro and in mice by degrading EWS–FLI1.The FLI1 domain in EWS–FLI1 is targeted by SPOP and OTUD7A."

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"These data support that changes in EWS–FLI1 following OTUD7A depletion affect a subset of EWS–FLI1 transcriptional targets.2.7 Quantitative Proteomics Identifies OTUD7A Downstream Targets Mediating Ewing Sarcoma Cell Migration."

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OTUD7A activates Sarcoma, Ewing. 3 / 3

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