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"Thus, Cezanne2 facilitates Cezanne in regulating Rap80/Abraxas/BRCA1 and Rad18 recruitment.Whereas knockdown of either Cezanne or Cezanne2 alone did not result in much change in 53BP1 IRIF (Fig. 7B; Supplemental Fig. S8), depletion of both genes by siRNAs, however, led to a significant decrease in 53BP1 IRIF (Fig. 7B)."