IndraLab

Statements

OTUD7A activates TP53BP1. 2 / 2
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reach
"The different roles of Cezanne and Cezanne2 in promoting Rap80 or Rad18 and 53BP1 suggest that the K63-dependent recruitments of DNA repair proteins are differentially regulated by Cezanne and Cezanne2."
31699778
reach
"These data indicate that both Cezanne and Cezanne2 are required to recruit 53BP1 to DNA damage sites.The defects caused by the deficiency of Cezanne2 in recruiting Rap80 and 53BP1 can be rescued by expression of Cezanne2 WT but not the DUB mutant (Cez2-CS) (Fig. 7C), indicating that the DUB activity of Cezanne2 is required for its function."
31699778