IndraLab

Statements

OTUD7A binds ANK3. 6 / 6
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"The interactions between OTUD7A and Ankyrin-G (Ank3) and Ankyrin-B (Ank2) were disrupted by an epilepsy-associated OTUD7A L233F variant."
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No evidence text available
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"OTUD7A binds to Ankyrin-G and Ankyrin-B, and shares a common PPI network."
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"These data suggest that there is a strong interaction between OTUD7A and Ankyrin-G/Ankyrin-B, and that OTUD7A may play a functional role at the ANKRD and/or spectrin-binding domain of Ankyrin-G."
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"In light of OTUD7A’s putative DUB function and our findings that the catalytic domain of OTUD7A binds to Ankyrin-G, we examined the ubiquitination status of Ankyrin-G in 15q13.3 microdeletion and OTUD7A iNeurons."
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"Given our data supporting the importance of the OTUD7A/Ankyrin-G interaction in 15q13.3 microdeletion neuronal phenotypes, as well as the observed changes in Ankyrin-G levels and stability in 15q13.3 microdeletion models, we examined whether re-expression of OTUD7A in Df(h15q13)/+ cortical neurons is sufficient to increase Ankyrin-G levels and rescue the protein homeostasis defects."
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