IndraLab

Statements

OTUD7A activates FLI1. 2 / 2
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"Remarkably, induced depletion of OTUD7A led to reduced EWS–FLI1 protein levels in multiple Ewing sarcoma cells, including A673 (Figure 3D), MHH‐ES‐1 (Figure 3E), and EWS894 (Figure 3F)."
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"These data suggest that OTUD7A/EWS–FLI1 signaling modulates a subset of EWS–FLI1 targets.In addition to characterized EWS–FLI1 target proteins whose protein abundance was controlled by OTUD7A (Figure 4D), there were additional 572 proteins downregulated by OTUD7A genetic depletion (Table S3, Supporting Information), suggesting they are potential targets for OTUD7A or uncharacterized EWS–FLI1 targets."
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