IndraLab

Statements


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"Here, we report that Cezanne2 expression is downregulated in HCC cells and in HCC patients' tumorous tissues and that Cezanne2 is inversely associated with Snail1 expression in HCC patients' tumorous tissues."

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"However, MPND and Cezanne2 slightly interact with Snail1 after proteasome inhibition ( xref ) suggesting that accumulation of poly-ubiquitinated Snail1 might favor the association with these particular DUBs."

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"Chromatin immunoprecipitation assays and the reporter gene assay showed that Snail1 binds to the promoter of the Cezanne2 gene and mediates the direct consequence of Cezanne2 repression."