IndraLab

Statements


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"In addition, the interaction between Ankyrin-B and OTUD7A was reduced by both patient mutations, suggesting that it may also contribute to 15q13.3 microdeletion neuronal phenotypes (Fig. 3a)."

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"The interactions between OTUD7A and Ankyrin-G (Ank3) and Ankyrin-B (Ank2) were disrupted by an epilepsy-associated OTUD7A L233F variant."

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"OTUD7A binds to Ankyrin-G and Ankyrin-B, and shares a common PPI network."

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"In addition, the interaction between Ankyrin-B and OTUD7A was reduced by both patient mutations, suggesting that it may also contribute to 15q13.3 microdeletion neuronal phenotypes (Fig.  xref )."

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"These data suggest that there is a strong interaction between OTUD7A and Ankyrin-G/Ankyrin-B, and that OTUD7A may play a functional role at the ANKRD and/or spectrin-binding domain of Ankyrin-G."