IndraLab

Statements

OTUD7A binds ANK1. 5 / 5
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"To validate our pipeline, we followed up on a top BioID2 hit, Ankyrin-G ( Ank3 ), and found that OTUD7A interacts with Ankyrin-G and regulates its protein homeostasis."
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"These results indicate a central role for a conserved OTUD7A-Ankyrin-G interaction in neuronal dysfunction in the 15q13.3 microdeletion, providing molecular insight into disease processes."
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"We tested whether OTUD7A interacts with Ankyrin-G-190 and/or Ankyrin-B through co-immunoprecipitation of tagged proteins in HEK293 cells."
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"We next identified the protein regions of Ankyrin-G that interact with OTUD7A through co-immunoprecipitation of overexpressed HA-tagged Ankyrin-G domains and OTUD7A-FLAG in HEK293 cells."
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"While the phenotypes are not expected to be identical between mouse and human iNeuron models, both models do show a level of convergence of molecular and cellular phenotypes, supporting the notion that disruption of the OTUD7A-Ankyrin-G interaction is a key pathogenic mechanism in the 15q13.3 microdeletion."
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