IndraLab

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OTUD7A decreases the amount of EWS-FLI1 Transcriptional Targets. 1 / 1
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"Consistent with EWS–FLI1 signaling being a major OTUD7A downstream effector, more than one tenth (62) of the downregulated proteins exert DNA‐binding transcriptional activity (Figure S12D, Supporting Information), many of which have been characterized to associate with EWS–FLI1 on chromatin, including CBP, forkhead box proteins, and zinc finger proteins.2.6 Genetic OTUD7A Inactivation Reduces Expression of EWS-FLI1 Transcriptional Targets."