IndraLab

Statements

USP34 is modified
22 | 5
USP34 is phosphorylated.
22 | 3
USP34 is phosphorylated. 3 / 3
| 3
sparser
"CYLD phosphorylation serine (S)418 and S422 sites are well documented in independent studies ( xref , xref ) and shown in xref C . USP34 phosphorylation S718 and S1751 sites have been identified in HeLa cells ( xref ) and are not shown in xref D , since there were less than ten reports, whereas no additional USP47 phosphorylation sites have been identified."
37865315
sparser
"M1320T, and ubiquitin specific peptidase 34 ( USP34 ) p."
33886505
sparser
"In contrast to CYLD, the function of USP34 phosphorylation sites is not known."
37865315
USP34 is phosphorylated on S3406. 2 / 2
2 |
hprd
No evidence text available
18452278
hprd
No evidence text available
18669648
USP34 is phosphorylated on S1377. 1 / 1
1 |
hprd
No evidence text available
20068231
USP34 is phosphorylated on T188. 1 / 1
1 |
hprd
No evidence text available
18077418
USP34 is phosphorylated on T3385. 1 / 1
1 |
hprd
No evidence text available
19651622
USP34 is phosphorylated on T679. 1 / 1
1 |
hprd
No evidence text available
20068231
USP34 is phosphorylated on S3358. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S3384. 1 / 1
1 |
hprd
No evidence text available
19651622
USP34 is phosphorylated on S352. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S1469. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S3411. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S2488. 1 / 1
1 |
hprd
No evidence text available
15345747
USP34 is phosphorylated on T3383. 1 / 1
1 |
hprd
No evidence text available
19651622
USP34 is phosphorylated on S1461. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on T667. 1 / 1
1 |
hprd
No evidence text available
20068231
USP34 is phosphorylated on S681. 1 / 1
1 |
hprd
No evidence text available
20068231
USP34 is phosphorylated on S3410. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S355. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S1473. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on Y3415. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S3359. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is phosphorylated on S1472. 1 / 1
1 |
hprd
No evidence text available
18669648
USP34 is ubiquitinated.
| 2
USP34 is ubiquitinated. 1 / 1
| 1
sparser
"Intriguingly, only USP34 ubiquitination at a single site K1968 has been reported on PhosphoSitePlus and detected in twelve discovery mass spectrometry studies ( xref D )."
37865315
USP34 is ubiquitinated on K1968. 1 / 1
| 1
sparser
"Intriguingly, only USP34 ubiquitination at a single site K1968 has been reported on PhosphoSitePlus and detected in twelve discovery mass spectrometry studies ( xref D )."
37865315
USP34 affects PIN1
1 | 20 2
USP34 deubiquitinates PIN1.
| 7
USP34 deubiquitinates PIN1. 7 / 7
| 7
reach
"Pin1 is deubiquitinated and stabilized by USP34 in GSCs."
38167292
reach
"Moreover, disruption of USP34 dramatically elevated poly-ubiquitination of Pin1 in GSCs (Fig. 1h, Supplementary Fig. 1f)."
38167292
reach
"Therefore, these data indicate that USP34 deubiquitinates and stabilizes Pin1 proteins."
38167292
reach
"In summary, these data demonstrate that USP34 deubiquitinates and stabilizes Pin1 in GSCs."
38167292
reach
"Here we demonstrate that Pin1 is deubiquitinated and stabilized by USP34, which promotes isomerization of the sole SUMO E2 enzyme Ubc9, leading to SUMO1-modified hypersumoylation to support GSC maintenance."
38167292
reach
"Disruption of USP34 or inhibition of Plk1 promotes poly-ubiquitination and degradation of Pin1."
38167292
reach
"We have shown that Pin1 is deubiquitinated and stabilized by USP34 in GSCs, resulting in the Pin1-catalyzed Ubc9 isomerization and the consequent SUMO1-modified hypersumoylation that are critical for GSC maintenance."
38167292
USP34 binds PIN1.
| 5 2
PIN1 binds USP34. 7 / 7
| 5 2
reach
"The interaction between USP34 and Pin1 in GSCs were validated by co-immunoprecipitation (Fig. 1d)."
38167292
reach
"Given that USP34 interacts with and stabilizes Pin1, we sought to explore the mechanisms regulating the affinity of Pin1 to USP34."
38167292
reach
"These data suggest that Plk1 promotes serine phosphorylation of Pin1 to stabilize Pin1 proteins in GSCs.We then investigated whether Plk1-mediated phosphorylation of Pin1 affected the interaction between Pin1 and USP34."
38167292
reach
"Co-immunoprecipitation analyses showed that inhibition of Plk1 by SBE 13 attenuated the interaction between Pin1 and USP34 (Fig. 2e)."
38167292
reach
"In addition, interfering the binding of Pin1 to USP34 by inhibiting Pin1 phosphorylation with the Plk1 inhibitor SBE 13 downregulated Pin1 expression (Fig. 2c), indicating Plk1 as another target to promote Pin1 degradation."
38167292
sparser
"Zhu et al.’s study revealed the interaction between Pin1 and ubiquitin specific peptidase 34 (USP34) in glioma stem cells."
38801243
sparser
"Pin1 interacts with USP34, a deubiquitinase with preferential expression and oncogenic function in GSCs."
38167292
USP34 increases the amount of PIN1.
| 5
USP34 increases the amount of PIN1. 5 / 5
| 5
reach
"Disruption of the endogenous USP34 with lentiviral-mediated short hairpin RNAs (shRNAs) resulted in a remarkable reduction of Pin1 protein levels in GSCs, whereas Pin1 mRNA levels did not decrease (Fig. 1g, Supplementary Fig. 1d, e), indicating that USP34 regulated Pin1 expression at the protein level."
38167292
reach
"Disruption of USP34 severely reduced Pin1 protein levels (Fig. 1g), suggesting that USP34 inhibitors, although not available so far, would inhibit Pin1 expression."
38167292
reach
"Additionally, we found that USP34 could increase the expression of PIN1 via SUMOylation in cervical cancer cells."
39752760
reach
"This study confirmed that USP34 could upregulate PIN1 expression and SUMOylation, thereby inhibiting ferroptosis by suppressing the cGAS-STING pathway and in turn promoting the progression of cervical cancer."
39752760
reach
"The above data indicate that USP34 as a Pin1-interacting DUB may positively regulate Pin1 expression in GSCs and GBMs.Next, we investigated whether USP34 had the capacity to deubiquitinate and stabilize Pin1 proteins in GSCs."
38167292
USP34 activates PIN1.
1 | 1
USP34 activates PIN1. 2 / 2
1 | 1
biopax:biofactoid
No evidence text available
reach
"We found that the affinity of USP34 to Pin1 is largely enhanced by the Plk1-mediated phosphorylation of Pin1 at S65, which is consistent with a previous report showing that phosphorylation of Pin1 at S65 by Plk1 suppresses Pin1 ubiquitination and increases Pin1 protein stability ."
38167292
USP34 sumoylates PIN1.
| 1
USP34 leads to the sumoylation of PIN1. 1 / 1
| 1
reach
"This study confirmed that USP34 could upregulate PIN1 expression and SUMOylation, thereby inhibiting ferroptosis by suppressing the cGAS-STING pathway and in turn promoting the progression of cervical cancer."
39752760
USP34 decreases the amount of PIN1.
| 1
USP34 decreases the amount of PIN1. 1 / 1
| 1
reach
"Disruption of USP34 severely reduced Pin1 protein levels (Fig. 1g), suggesting that USP34 inhibitors, although not available so far, would inhibit Pin1 expression."
38167292
USP34 affects AMFR
2 1 | 6 7
USP34 binds AMFR.
2 | 3 7
AMFR binds USP34. 10 / 12
2 | 3 7
sparser
"Together, biochemical and microscopy analyses indicate that USP34 is associated with gp78."
30585151
sparser
"Further investigation of the interaction between USP34 and gp78 will advance our understanding of the regulation of protein ubiquitylation."
30585151
sparser
"The association of USP34 with gp78 prompted us to examine if USP34 regulates the degradation of gp78."
30585151
biogrid
No evidence text available
30585151
biogrid
No evidence text available
30585151
reach
"To verify the interaction between gp78 and USP34, we performed a conventional co-IP/immunoblotting assay."
30585151
reach
"Here we demonstrate that USP34 interacts with and deubiquitylates gp78, preventing it from degradation by the proteasome."
30585151
sparser
"USP34 interacts with gp78 and prevents it from proteasomal degradation via reducing its ubiquitylation."
30585151
sparser
"We found that USP34 is associated with gp78."
30585151
reach
"Further investigation of the interaction between USP34 and gp78 will advance our understanding of the regulation of protein ubiquitylation.The authors declare that they have no conflicts of interest w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30585151
USP34 deubiquitinates AMFR.
1 | 2
USP34 deubiquitinates AMFR. 3 / 3
1 | 2
reach
"Here we demonstrate that USP34 interacts with and deubiquitylates gp78, preventing it from degradation by the proteasome."
30585151
reach
"Thus, ubiquitylation of gp78 is increased by knockdown of USP34, in line with its effect on gp78 degradation.We next assessed the relevance of USP34 to the biological functions of gp78."
30585151
ubibrowser
"The ubiquitin specific protease <span class="match term0">USP34</span> protects the ubiquitin ligase <span class="match term1">gp78</span> from proteasomal degradation"
30585151
USP34 activates AMFR.
| 1
USP34 activates AMFR. 1 / 1
| 1
reach
"Knockdown of USP34 causes rapid degradation of gp78 and impairs the function of gp78 in regulating lipid droplet formation in liver cells."
30585151
USP34 affects RNF168
1 | 10 3
USP34 binds RNF168.
| 4 3
USP34 binds RNF168. 7 / 7
| 4 3
reach
"As USP34 interacted with RNF168, but not RNF8 (XREF_FIG C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."
23863847
reach
"USP34 [123] and USP7 [124] directly associate with RNF168 to prevent its poly-ubiquitylation and subsequent degradation via the proteasome (Figure 2A)."
38572758
sparser
"As USP34 interacted with RNF168, but not RNF8 ( xref C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."
23863847
reach
"USP34 also associates and stabilizes RNF168 especially after IR, thereby enhancing H2A and gammaH2AX ubiquitylation."
28764946
sparser
"In line with our observation, a previous study showed that USP34 binds and stabilizes RNF168, an E3 required for DNA DSB-associated ubiquitylation [ 25 ]."
30585151
reach
"In line with our observation, a previous study showed that USP34 binds and stabilizes RNF168, an E3 required for DNA DSB-associated ubiquitylation [ 25 ]."
30585151
sparser
"The exact substrate subjected to USP34-RNF168 regulation remains to be identified."
30585151
USP34 deubiquitinates RNF168.
1 | 2
USP34 deubiquitinates RNF168. 3 / 3
1 | 2
reach
"Upon DNA damage, the short-lived RNF168 is deubiquitinated and stabilized by USP34, which functions to counteract the autoubiquitination and degradation of RNF168 and subsequently activate DNA damage [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35588869
reach
"A similar observation was seen when we immunoblotted immunoprecipitated RNF168 proteins with antibodies specific for lys48-ubiquitin linkages (XREF_FIG D), suggesting that USP34 may deubiquitylate and stablize RNF168."
23863847
ubibrowser
"28031783"
28031783
USP34 activates RNF168.
| 2
USP34 activates RNF168. 2 / 2
| 2
reach
"Specifically, USP34 promotes RNF168 dependent functions at DSBs."
30831436
reach
"We concluded that USP34 promotes RNF168 dependent ubiquitylation events at DSBs."
23863847
USP34 ubiquitinates RNF168.
| 1
USP34 ubiquitinates RNF168. 1 / 1
| 1
reach
"Upon DNA damage, the short-lived RNF168 is deubiquitinated and stabilized by USP34, which functions to counteract the autoubiquitination and degradation of RNF168 and subsequently activate DNA damage [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35588869
USP34 inhibits RNF168.
| 1
USP34 inhibits RNF168. 1 / 1
| 1
reach
"Another DUB, USP7, has also been shown to deubiquitinate and stabilize RNF168 [XREF_BIBR]; however, RNF168 is itself polyubiquitinated and destabilized upon IR treatment, which is reversed by USP34, suggesting that USP34 specifically stabilizes RNF168 when DNA becomes damaged [XREF_BIBR]."
30831436
ATM affects USP34
2 2 | 3 5
ATM binds USP34.
2 | 2 5
ATM binds USP34. 9 / 9
2 | 2 5
sparser
"We found the possible binding of USP34 with ATM, which was further testified with co-IP ( Fig. 4 B)."
37043976
sparser
"Mechanically, USP34 interacts with ATM to inhibit the expression of Ccl2, Ccl5, and Il12α in LPS-stimulated BMDMs."
37043976
biogrid
No evidence text available
17478428
biogrid
No evidence text available
37043976
sparser
"Such inflammation inhibition may be attributed to the interaction between USP34 and ataxia telangiectasia-mutated (ATM)."
37043976
reach
"Immunoprecipitation demonstrated the interaction between USP34 and ATM."
37043976
reach
"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."
37043976
sparser
"In our study, we hypothesize that USP34 can interact with ATM, and USP34 may function as a ubiquitin hydrolase to maintain the stability of ATM."
37043976
sparser
"It is worth noting that the precise mechanism related to the interaction between USP34 and ATM is not deciphered in this study, which will require further analysis."
37043976
ATM phosphorylates USP34.
2 |
ATM phosphorylates USP34 on S718. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
ATM phosphorylates USP34 on S1751. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
ATM activates USP34.
| 1
ATM activates USP34. 1 / 1
| 1
reach
"As chemical inhibition of ATM using KU55933 inhibited USP34 IRIF, we examined whether DSB association of USP34 may require an intact H2AX dependent DNA damage signaling pathway."
23863847
AMFR affects USP34
2 | 3 7
AMFR binds USP34. 10 / 12
2 | 3 7
sparser
"Together, biochemical and microscopy analyses indicate that USP34 is associated with gp78."
30585151
sparser
"Further investigation of the interaction between USP34 and gp78 will advance our understanding of the regulation of protein ubiquitylation."
30585151
sparser
"The association of USP34 with gp78 prompted us to examine if USP34 regulates the degradation of gp78."
30585151
biogrid
No evidence text available
30585151
biogrid
No evidence text available
30585151
reach
"To verify the interaction between gp78 and USP34, we performed a conventional co-IP/immunoblotting assay."
30585151
reach
"Here we demonstrate that USP34 interacts with and deubiquitylates gp78, preventing it from degradation by the proteasome."
30585151
sparser
"USP34 interacts with gp78 and prevents it from proteasomal degradation via reducing its ubiquitylation."
30585151
sparser
"We found that USP34 is associated with gp78."
30585151
reach
"Further investigation of the interaction between USP34 and gp78 will advance our understanding of the regulation of protein ubiquitylation.The authors declare that they have no conflicts of interest w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30585151
USP34 affects NFIC
1 | 1 7 1
USP34 deubiquitinates NFIC.
| 5
USP34 deubiquitinates NFIC. 5 / 5
| 5
reach
"Mechanically, we demonstrated that USP34 deubiquitinates and stabilizes NFIC during odontoblast differentiation."
33686052
reach
"USP34 deubiquitinates and stabilizes NFIC."
33686052
reach
"Ubiquitination assay showed increased ubiquitination level of NFIC in USP34 deficient 293T cells, indicating the presence of USP34 dependent deubiquitination of NFIC."
33686052
reach
"To test whether USP34 dependent deubiquitination of NFIC is involved in odontogenic differentiation of DPCs, DPCs were infected with Lv-NFIC, or Lv-GFP as control."
33686052
reach
"XREF_BIBR, XREF_BIBR Our research identified that USP34 deubiquitinates and stabilizes NFIC to promote odontoblast differentiation and thus regulates root formation."
33686052
USP34 binds NFIC.
1 | 1 1
NFIC binds USP34. 2 / 2
1 | 1
sparser
"To uncover the molecular interaction between USP34 and NFIC, we transduced 293 T cells with Lv-NFIC and then performed co-IP analysis."
33686052
biogrid
No evidence text available
39617063
USP34 binds NFIC and 293T. 1 / 1
| 1
reach
"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."
33686052
USP34 inhibits NFIC.
| 1
USP34 inhibits NFIC. 1 / 1
| 1
reach
"Furthermore, we treated 293T cells with cycloheximide (CHX), a protein translation inhibitor, and observed that depletion of USP34 accelerated the degradation of NFIC."
33686052
USP34 activates NFIC.
| 1
USP34 activates NFIC. 1 / 1
| 1
eidos
"Furthermore , we treated 293 T cells with cycloheximide ( CHX ) , a protein translation inhibitor , and observed that depletion of USP34 accelerated the degradation of NFIC ( Fig. 4b , d ) ."
33686052
reach
"PLAGL2 also activates the expression of USP34 deubiqutinase that in turn stabilizes Snail1 and promotes proliferation and migration of gastric cancer cells [63]."
35563824
reach
"Functional studies found that knockdown of USP34 inhibited HepG2 and HepG2/DDP cell proliferation and survival."
40051889
reach
"In addition, the level of USP34 was upregulated in pancreatic cancer, and USP34 promoted the proliferation and migration of pancreatic cancer cells, as well as inhibited cell apoptosis [17]."
40051889
reach
"Pancreatic cancer cell proliferation and migration are promoted by USP34 overexpression via upregulation of the Akt protein, and pancreatic cancer cell apoptosis induced by an Akt inhibitor is reversed by USP34 overexpression (35)."
37664545
reach
"In addition, USP34 overexpression promoted PANC-1 cell proliferation and migration via up-regulating the proteins of p-AKT and p-PKC."
30686807
reach
"USP34 can also promote the proliferation and migration of pancreatic cancer cells by upregulating p-AKT and p-PKC proteins (Gu et al., 2019)."
37409345
USP34 inhibits cell population proliferation. 3 / 3
| 3
reach
"The results showed that interference with USP34 inhibited the proliferation and survival of HCC cells and increased the sensitivity of drug-resistant cells to cisplatin."
40051889
reach
"In addition, interference with USP34 inhibited the proliferation and survival of HCC cells, and increased the sensitivity of drug-resistant cells to cisplatin."
40051889
reach
"USP34 downregulation could inhibit the proliferation and migration of the pancreatic cancer cell line PANC-1."
35588869
USP34 affects ATM
2 | 2 5
ATM binds USP34. 9 / 9
2 | 2 5
sparser
"We found the possible binding of USP34 with ATM, which was further testified with co-IP ( Fig. 4 B)."
37043976
sparser
"Mechanically, USP34 interacts with ATM to inhibit the expression of Ccl2, Ccl5, and Il12α in LPS-stimulated BMDMs."
37043976
biogrid
No evidence text available
17478428
biogrid
No evidence text available
37043976
sparser
"Such inflammation inhibition may be attributed to the interaction between USP34 and ataxia telangiectasia-mutated (ATM)."
37043976
reach
"Immunoprecipitation demonstrated the interaction between USP34 and ATM."
37043976
reach
"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."
37043976
sparser
"In our study, we hypothesize that USP34 can interact with ATM, and USP34 may function as a ubiquitin hydrolase to maintain the stability of ATM."
37043976
sparser
"It is worth noting that the precise mechanism related to the interaction between USP34 and ATM is not deciphered in this study, which will require further analysis."
37043976
PIN1 affects USP34
| 6 2
PIN1 binds USP34.
| 5 2
PIN1 binds USP34. 7 / 7
| 5 2
reach
"The interaction between USP34 and Pin1 in GSCs were validated by co-immunoprecipitation (Fig. 1d)."
38167292
reach
"Given that USP34 interacts with and stabilizes Pin1, we sought to explore the mechanisms regulating the affinity of Pin1 to USP34."
38167292
reach
"These data suggest that Plk1 promotes serine phosphorylation of Pin1 to stabilize Pin1 proteins in GSCs.We then investigated whether Plk1-mediated phosphorylation of Pin1 affected the interaction between Pin1 and USP34."
38167292
reach
"Co-immunoprecipitation analyses showed that inhibition of Plk1 by SBE 13 attenuated the interaction between Pin1 and USP34 (Fig. 2e)."
38167292
reach
"In addition, interfering the binding of Pin1 to USP34 by inhibiting Pin1 phosphorylation with the Plk1 inhibitor SBE 13 downregulated Pin1 expression (Fig. 2c), indicating Plk1 as another target to promote Pin1 degradation."
38167292
sparser
"Zhu et al.’s study revealed the interaction between Pin1 and ubiquitin specific peptidase 34 (USP34) in glioma stem cells."
38801243
sparser
"Pin1 interacts with USP34, a deubiquitinase with preferential expression and oncogenic function in GSCs."
38167292
PIN1 activates USP34.
| 1
PIN1 activates USP34. 1 / 1
| 1
reach
"In order to determine whether phosphorylation of S65 in Pin1 promoted the binding of USP34, we constructed a Pin1 S65A mutant by substitution of serine with alanine."
38167292
USP34 affects AXIN
| 7
USP34 activates AXIN.
| 3
USP34 activates AXIN. 3 / 3
| 3
reach
"In colon carcinoma cell lines that show activation of Wnt and beta-catenin signaling downstream of the DC, Axin and USP34 were found to positively regulate beta-catenin-dependent transcription [XREF_BIBR] whereby USP34 supported the nuclear accumulation of Axin [XREF_BIBR]."
24975604
reach
"Recent studies have found that USP34 is a component of the Axin complex, and directly regulates the β-catenin destruction complex by mediating Axin stability [20] ."
28499884
reach
"For example, USP34 increases the stability of Axin, thereby promoting its nuclear accumulation (Lui et al., 2011)."
26189775
USP34 deubiquitinates AXIN.
| 2
USP34 deubiquitinates AXIN. 2 / 2
| 2
reach
"A component of the destruction complex, Axin, is ubiquitinated by RNF146, Smurf1/2, and Siah1 and deubiquitinated by USP7, USP34, and USP44 (Kim and Jho 2010; Lui et al. 2011; Zhang et al. 2011; Fei et al. 2013;  Ji et al. 2017; Ji et al. 2019; Huang et al. 2020)."
38383910
reach
"UBPY and USP8 positively regulates the pathway by modifying Frizzled (Mukai et al., 2010), whereas USP34 deubiquitinates Axin and consequently works as a negative regulator of the WNT pathway (Lui et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26189775
USP34 ubiquitinates AXIN.
| 1
USP34 ubiquitinates AXIN. 1 / 1
| 1
reach
"Additionally, the deubiquitylase (DUB) USP34 was found to antagonize ubiquitylation of AXIN, promoting its stabilization and function in the canonical WNT pathway (Lui et al., 2011)."
31340145
USP34 binds AXIN.
| 1
USP34 binds AXIN. 1 / 1
| 1
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
32140262
RNF168 affects USP34
| 4 3
USP34 binds RNF168. 7 / 7
| 4 3
reach
"As USP34 interacted with RNF168, but not RNF8 (XREF_FIG C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."
23863847
reach
"USP34 [123] and USP7 [124] directly associate with RNF168 to prevent its poly-ubiquitylation and subsequent degradation via the proteasome (Figure 2A)."
38572758
sparser
"As USP34 interacted with RNF168, but not RNF8 ( xref C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."
23863847
reach
"USP34 also associates and stabilizes RNF168 especially after IR, thereby enhancing H2A and gammaH2AX ubiquitylation."
28764946
sparser
"In line with our observation, a previous study showed that USP34 binds and stabilizes RNF168, an E3 required for DNA DSB-associated ubiquitylation [ 25 ]."
30585151
reach
"In line with our observation, a previous study showed that USP34 binds and stabilizes RNF168, an E3 required for DNA DSB-associated ubiquitylation [ 25 ]."
30585151
sparser
"The exact substrate subjected to USP34-RNF168 regulation remains to be identified."
30585151
Bisphenol A affects USP34
6 |
Bisphenol A decreases the amount of USP34.
3 |
Bisphenol A decreases the amount of USP34. 3 / 3
3 |
ctd
No evidence text available
38074096
ctd
No evidence text available
31675489
ctd
No evidence text available
30816183
Bisphenol A increases the amount of USP34.
2 |
Bisphenol A increases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
38866337
ctd
No evidence text available
35598803
Bisphenol A methylates USP34.
1 |
Bisphenol A methylates USP34. 1 / 1
1 |
ctd
No evidence text available
28505145
USP34 affects Wnt
| 5 1
USP34 activates Wnt.
| 4
USP34 activates Wnt. 4 / 4
| 4
reach
"For example, Christodoulides et al. reported that mutation C256Y in WNT10B was associated with overweight or obesity because the mutation was unable to activate canonical Wnt pathway [XREF_BIBR]; and Choi et al. found that indirubin-3 '-oxime (I3O), also an activator of the Wnt signaling like USP34, inhibited the development of obesity in high-fat diet fed mice [XREF_BIBR]."
25975428
reach
"Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC."
31943775
reach
"Moreover, USP34 positively regulates Wnt signaling pathway [XREF_BIBR] and plays a role in DNA damage response control [XREF_BIBR]."
28493913
reach
"Moreover, USP34 positively regulates Wnt signaling pathway [XREF_BIBR], which plays an important role in gender differentiation, folliculogenesis, ovulation and other biological processes in reproduction [XREF_BIBR]."
25975428
USP34 inhibits Wnt.
| 1
USP34 inhibits Wnt. 1 / 1
| 1
reach
"This indicates that USP34 suppresses Wnt and beta-catenin signaling, due to degradation of beta-catenin resulting from increased stability of AXIN1 [XREF_BIBR]."
32486158
USP34 binds Wnt.
| 1
USP34 binds Wnt. 1 / 1
| 1
sparser
"Lasted studies have reported that snoRNAs could directly bind to functional protein to promote tumorigenesis. xref , xref Therefore, we inferred that USP34 or SNORA70B might bind WNT pathway–related protein to activate it."
31943775
USP34 affects SOX2
3 | 2 1
USP34 binds SOX2.
3 | 1 1
SOX2 binds USP34. 5 / 5
3 | 1 1
reach
"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."
32783291
sparser
"Moreover, in cisplatin-resistant laryngeal squamous cell carcinoma (LSCC) cells, USP34’s interaction with SOX2, a key CSC- and EMT-related transcription factor, decreases SOX2 polyubiquitination and augments LSCC cell sensitivity to cisplatin [ xref ] (Fig. xref A)."
38702734
biogrid
No evidence text available
32783291
biogrid
No evidence text available
32783291
biogrid
No evidence text available
23667531
USP34 decreases the amount of SOX2.
| 1
USP34 decreases the amount of SOX2. 1 / 1
| 1
reach
"Usp9x KD but not Usp34 KD (XREF_FIG) reduced SOX2 levels in both BRAF mutant A375, SK-Mel28 (XREF_FIG), and NRAS-mutant SK-Mel147 (XREF_FIG) melanoma cell lines."
33613844
USP34 activates cell differentiation.
| 4
USP34 activates cell differentiation. 4 / 4
| 4
reach
"In addition, osteogenic differentiation was inhibited by USP34 depletion [40] and USP2 was also reported to be associated with osteogenesis [41]."
36859264
reach
"Indeed, USP34-deficient dental pulp cells (DPCs) inhibited odontogenic differentiation with downregulation of nuclear factor I/C (NFIC), and overexpression of NFIC partially restores the impaired odontogenic potential of DPCs, as reported by Jiang et al. (2021)."
38515628
reach
"Importantly, USP34 modulates osteogenic differentiation and bone formation by regulating BMP2 signaling gradients (Guo et al., 2018)."
32582299
reach
"Guo et al. found that USP34 accelerated osteogenic differentiation and bone formation through activation of BMP2 signalling [ 27 ]."
33127578
USP34 inhibits cell differentiation.
| 1
USP34 inhibits cell differentiation. 1 / 1
| 1
reach
"The expression of USP34 in human MSCs increases after osteogenic induction while depletion of USP34 inhibits osteogenic differentiation."
30181118
USP34 affects NFkappaB
| 4 1
USP34 activates NFkappaB.
| 3
USP34 activates NFkappaB. 3 / 3
| 3
reach
"Hence, our results suggest that USP34 likely functions downstream of the CBM-IKK nexus to enhance NF-kappaB activation."
23590831
reach
"Combined, these results indicate that USP34 shares some functional similarities with CYLD and selectively targets the NF-kappaB signaling pathway."
23590831
reach
"We present evidence that knockdown of Ubiquitin Specific Protease 34 (USP34) selectively enhanced NF-kappaB activation driven by TCR engagement, similarly to siRNA against the well characterized DUB cylindromatosis (CYLD)."
23590831
USP34 inhibits NFkappaB.
| 1
USP34 inhibits NFkappaB. 1 / 1
| 1
reach
"USP34 also suppresses NFkappaB activation."
24712463
USP34 binds NFkappaB.
| 1
USP34 binds NFkappaB. 1 / 1
| 1
sparser
"Given that USP34 does not bind to the NF-κB core components (our unpublished results), we favor a model in which USP34 impacts on the activity of a cytosolic co-activator to ensure IκBα fine-tuning [ xref , xref ]."
23590831
USP34 affects CSNK1A1
5 |
CSNK1A1 binds USP34. 5 / 5
5 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
32707033
biogrid
No evidence text available
35271311
biogrid
No evidence text available
23455922
USP34 affects AXIN1
1 1 | 3
USP34 deubiquitinates AXIN1.
1 1 | 1
USP34 leads to the deubiquitination of AXIN1. 2 / 2
1 | 1
reach
"USP34 reduced the ubiquitination of AXIN1, but the catalytic mutant of USP34 does not reduce the ubiquitination of AXIN1."
32486158
ubibrowser
No evidence text available
USP34 deubiquitinates AXIN1 on lysine. 1 / 1
1 |
biopax:reactome
No evidence text available
USP34 ubiquitinates AXIN1.
| 1
Mutated USP34 leads to the ubiquitination of AXIN1. 1 / 1
| 1
reach
"USP34 reduced the ubiquitination of AXIN1, but the catalytic mutant of USP34 does not reduce the ubiquitination of AXIN1."
32486158
USP34 activates AXIN1.
| 1
USP34 activates AXIN1. 1 / 1
| 1
reach
"Furthermore, a cycloheximide pulse-chase assay revealed that USP34 knockdown caused significant degradation of Axin 1 (Supplementary Fig. S1), implying that USP34 may be a negative regulator of the EM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28499884
SOX2 affects USP34
3 | 1 1
SOX2 binds USP34. 5 / 5
3 | 1 1
reach
"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."
32783291
sparser
"Moreover, in cisplatin-resistant laryngeal squamous cell carcinoma (LSCC) cells, USP34’s interaction with SOX2, a key CSC- and EMT-related transcription factor, decreases SOX2 polyubiquitination and augments LSCC cell sensitivity to cisplatin [ xref ] (Fig. xref A)."
38702734
biogrid
No evidence text available
32783291
biogrid
No evidence text available
32783291
biogrid
No evidence text available
23667531
CSNK1A1 affects USP34
5 |
CSNK1A1 binds USP34. 5 / 5
5 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
32707033
biogrid
No evidence text available
35271311
biogrid
No evidence text available
23455922
Rep affects USP34
4 |
Rep binds USP34. 4 / 4
4 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
34672954
Benzo[a]pyrene affects USP34
4 |
Benzo[a]pyrene decreases the amount of USP34.
3 |
Benzo[a]pyrene decreases the amount of USP34. 3 / 3
3 |
ctd
No evidence text available
21632981
ctd
No evidence text available
20106945
ctd
No evidence text available
26001963
Benzo[a]pyrene increases the amount of USP34.
1 |
Benzo[a]pyrene increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
26238291
Ubiquitin affects USP34
| 4
USP34 binds Ubiquitin. 4 / 4
| 4
sparser
"The structure of the complex between USP34 and Ub-PA reveals a structural basis for the distal ubiquitin recognition of USP34."
35588869
sparser
"To evaluate the structural observations, we assessed the effects of a series of mutations that are suspected to disrupt USP34-Ub contacts on the deubiquitination activity of USP34."
35588869
sparser
"The interactions between USP34 and Ub-PA result in the burial of 1704 Å 2 of exposed surface area and a relatively closed conformation of the USP34 structure."
35588869
sparser
"This analysis explains why H2164 does not form the mis-aligned conformation in the ubiquitin-bound complex of USP34: the main chain of G2162 could not employ the same conformation that is required for[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35588869
USP34 affects rep
4 |
Rep binds USP34. 4 / 4
4 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
34672954
eidos
"Inhibition of USP34 induces EMT and stemness in mammary epithelial cells [ 63 ] ."
31133011
reach
"Furthermore, a cycloheximide pulse-chase assay revealed that USP34 knockdown caused significant degradation of Axin 1 (Supplementary Fig. S1), implying that USP34 may be a negative regulator of the EM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28499884
reach
"Following USP34-KD cell transplantation, increased MMP-2 secretion likely contributes to mammary ductal invasion.In the present study, we have demonstrated for the first time that: (i) USP34 is downre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28499884
reach
"USP34 and USP37 stimulate EMT in mammary epithelial cells [84,85] ."
34678225
USP34 affects cisplatin
| 4
USP34 inhibits cisplatin.
| 3
USP34 inhibits cisplatin. 3 / 3
| 3
reach
"Importantly, knockdown of USP34 enhanced cisplatin sensitivity in HepG2 and HepG2/DDP cells."
40051889
reach
"Knockdown of USP34 enhanced cisplatin sensitivity in HepG2 and HepG2/DDP cells."
40051889
reach
"27 The deletion of USP34 inhibited the survival of laryngeal squamous cell carcinoma cells and reduced the drug resistance of cisplatin in these cells."
35588869
USP34 activates cisplatin.
| 1
USP34 activates cisplatin. 1 / 1
| 1
reach
"This study found that the expression levels of USP34 were increased in cisplatin-resistant HCC tissues and cells, and interference with USP34 increased cisplatin sensitivity in HCC cells.Histone lactylation is a novel post-translational modification of proteins, which is related to cellular metabolism and gene expression regulation, and has attracted much attention in tumor biology [20]."
40051889
USP34 affects Ubiquitin
| 4
USP34 binds Ubiquitin. 4 / 4
| 4
sparser
"The structure of the complex between USP34 and Ub-PA reveals a structural basis for the distal ubiquitin recognition of USP34."
35588869
sparser
"To evaluate the structural observations, we assessed the effects of a series of mutations that are suspected to disrupt USP34-Ub contacts on the deubiquitination activity of USP34."
35588869
sparser
"The interactions between USP34 and Ub-PA result in the burial of 1704 Å 2 of exposed surface area and a relatively closed conformation of the USP34 structure."
35588869
sparser
"This analysis explains why H2164 does not form the mis-aligned conformation in the ubiquitin-bound complex of USP34: the main chain of G2162 could not employ the same conformation that is required for[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35588869
USP34 affects SUMO1
| 4
USP34 sumoylates SUMO1.
| 2
USP34 leads to the sumoylation of SUMO1. 2 / 2
| 2
reach
"We proposed that USP34 promoted protein SUMO1-sumoylation via stabilization of Pin1."
38167292
reach
"Indeed, immunoblot analyses showed that although disruption of USP34 almost abrogated SUMO1-sumoylation, ectopic expression of Pin1-K117 largely restored protein SUMO1-sumoylation in GSCs (Fig. 4f, Supplementary Fig. 3h)."
38167292
USP34 activates SUMO1.
| 2
USP34 activates SUMO1. 2 / 2
| 2
reach
"Taken together, the above data demonstrate that USP34 upregulates SUMO1-modified protein sumoylation via Pin1 in GSCs."
38167292
reach
"Because the stabilization of Pin1 by USP34 promoted SUMO1-modified protein sumoylation in GSCs, we sought to explore the Pin1 isomerase substrates involved in hypersumoylation."
38167292
USP34 affects Cell Survival
| 4
USP34 activates Cell Survival.
| 3
USP34 activates Cell Survival. 3 / 3
| 3
reach
"Research reports that knockdown of USP34 increases the drug sensitivity of laryngeal squamous cells to cisplatin and reduces cell survival rate [10]."
40051889
reach
"Knockdown of USP34 inhibited HepG2 and HepG2/DDP cell viability and survival."
40051889
reach
"We found that knockdown of USP34 reduced the cell viability and IC of HCC cells (Fig. 3a-d)."
40051889
USP34 inhibits Cell Survival.
| 1
USP34 inhibits Cell Survival. 1 / 1
| 1
reach
"Further research has found that interference with USP34 inhibited the cell viability (Fig. 2c) and promoted apoptosis of HepG2 and HepG2/DDP cells (Fig. 2d)."
40051889
USP34 affects CTNNB1
| 4
USP34 inhibits CTNNB1.
| 1
USP34 inhibits CTNNB1. 1 / 1
| 1
reach
"This indicates that USP34 suppresses Wnt and beta-catenin signaling, due to degradation of beta-catenin resulting from increased stability of AXIN1 [XREF_BIBR]."
32486158
USP34 decreases the amount of CTNNB1.
| 1
Modified USP34 decreases the amount of CTNNB1. 1 / 1
| 1
reach
"Also, decreased USP34 expression resulted in decreased expression of AXIN1, and increased expression of beta-catenin."
32486158
USP34 binds CTNNB1.
| 1
USP34 binds CTNNB1. 1 / 1
| 1
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
32140262
USP34 activates CTNNB1.
| 1
USP34 activates CTNNB1. 1 / 1
| 1
reach
"Recent studies have found that USP34 is a component of the Axin complex, and directly regulates the β-catenin destruction complex by mediating Axin stability [20] ."
28499884
USP34 affects 7a
2 2 |
USP34 binds 7a. 2 / 2
1 1 |
virhostnet
No evidence text available
33845483
biogrid
No evidence text available
33845483
USP34 binds 7a. 2 / 2
1 1 |
virhostnet
No evidence text available
33845483
biogrid
No evidence text available
33845483
NFIC affects USP34
1 | 2 1
NFIC binds USP34.
1 | 1 1
NFIC binds USP34. 2 / 2
1 | 1
sparser
"To uncover the molecular interaction between USP34 and NFIC, we transduced 293 T cells with Lv-NFIC and then performed co-IP analysis."
33686052
biogrid
No evidence text available
39617063
USP34 binds NFIC and 293T. 1 / 1
| 1
reach
"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."
33686052
NFIC activates USP34.
| 1
NFIC activates USP34. 1 / 1
| 1
reach
"Overexpression of NFIC partially rescues the odontogenic potential of USP34 deficient DPCs."
33686052
MYC affects USP34
3 1 |
MYC decreases the amount of USP34.
3 |
MYC decreases the amount of USP34. 3 / 3
3 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
MYC binds USP34.
1 |
MYC binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32140074
7a affects USP34
2 2 |
USP34 binds 7a. 2 / 2
1 1 |
virhostnet
No evidence text available
33845483
biogrid
No evidence text available
33845483
USP34 binds 7a. 2 / 2
1 1 |
virhostnet
No evidence text available
33845483
biogrid
No evidence text available
33845483
Trichostatin A affects USP34
3 |
Trichostatin A decreases the amount of USP34.
2 |
Trichostatin A decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Trichostatin A increases the amount of USP34.
1 |
Trichostatin A increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
24935251
ZNF707 affects USP34
3 |
ZNF707 binds USP34. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects glioblastoma multiforme cancer stem cell
| 3
USP34 activates glioblastoma multiforme cancer stem cell. 3 / 3
| 3
reach
"USP34 is preferentially expressed in GSCs to promote GSC maintenance and GBM tumor growth."
38167292
reach
"These phenomena demonstrate that USP34 functions to promote GSC maintenance."
38167292
reach
"Collectively, these data demonstrate that USP34 promotes GSC maintenance and GBM tumor growth."
38167292
USP34 affects ZNF707
3 |
ZNF707 binds USP34. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects UBC
3 |
UBC binds USP34. 3 / 3
3 |
biogrid
No evidence text available
29576527
biogrid
No evidence text available
35588869
biogrid
No evidence text available
35588869
USP34 affects NPPA
| 3
NPPA binds USP34. 3 / 3
| 3
sparser
"The Carr index was used to determine powder flowability according to USP criteria ( Table 2 ) ( USP34-NF29, 2011 )."
22099254
sparser
"As a result of the corrosion and leaking of heavy metal compounds, no one of available CHIs met the pharmaceutical requirement in terms of contamination by residual heavy metals, especially by Fe, Cr [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30981360
sparser
"Remediation of a commercial technical-grade CHI was carried out for preparation of a series of medical-grade oligoCHI·HCl samples with residual heavy metals and arsenic content below the limit (Fe≤10,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30981360
USP34 affects Histone
| 2 1
USP34 ubiquitinates Histone.
| 1 1
USP34 leads to the ubiquitination of Histone. 2 / 2
| 1 1
reach
"USP34 promotes DNA damage induced histone ubiquitylation."
23863847
sparser
"USP34 promotes DNA damage-induced histone ubiquitylation."
23863847
USP34 increases the amount of Histone.
| 1
USP34 increases the amount of Histone. 1 / 1
| 1
reach
"USP34 promotes the progression of HCC by regulating histone lactylation levels and cisplatin resistance in HCC."
40051889
USP34 affects HYCC1
| 3
USP34 inhibits HYCC1.
| 2
USP34 inhibits HYCC1. 2 / 2
| 2
reach
"In addition, interference with USP34 inhibited the proliferation and survival of HCC cells, and increased the sensitivity of drug-resistant cells to cisplatin."
40051889
reach
"The results showed that interference with USP34 inhibited the proliferation and survival of HCC cells and increased the sensitivity of drug-resistant cells to cisplatin."
40051889
USP34 activates HYCC1.
| 1
USP34 activates HYCC1. 1 / 1
| 1
reach
"We found that knockdown of USP34 reduced the cell viability and IC of HCC cells (Fig. 3a-d)."
40051889
USP34 affects EIF3M
3 |
EIF3M binds USP34. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
UBC affects USP34
3 |
UBC binds USP34. 3 / 3
3 |
biogrid
No evidence text available
29576527
biogrid
No evidence text available
35588869
biogrid
No evidence text available
35588869
NPPA affects USP34
| 3
NPPA binds USP34. 3 / 3
| 3
sparser
"The Carr index was used to determine powder flowability according to USP criteria ( Table 2 ) ( USP34-NF29, 2011 )."
22099254
sparser
"As a result of the corrosion and leaking of heavy metal compounds, no one of available CHIs met the pharmaceutical requirement in terms of contamination by residual heavy metals, especially by Fe, Cr [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30981360
sparser
"Remediation of a commercial technical-grade CHI was carried out for preparation of a series of medical-grade oligoCHI·HCl samples with residual heavy metals and arsenic content below the limit (Fe≤10,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30981360
EIF3M affects USP34
3 |
EIF3M binds USP34. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CEBPA affects USP34
3 |
CEBPA decreases the amount of USP34. 3 / 3
3 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP34.
2 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
21215274
ctd
No evidence text available
19770486
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP34.
1 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
34747641
Valproic acid affects USP34
2 |
Valproic acid decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
25192806
ctd
No evidence text available
23179753
Succimer affects USP34
2 |
Succimer decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
26378955
ctd
No evidence text available
21641980
Sodium arsenite affects USP34
2 |
Sodium arsenite increases the amount of USP34.
1 |
Sodium arsenite increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Sodium arsenite decreases the amount of USP34.
1 |
Sodium arsenite decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Manganese(II) chloride increases the amount of USP34.
1 |
Manganese(II) chloride increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Manganese(II) chloride decreases the amount of USP34.
1 |
Manganese(II) chloride decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Manganese atom affects USP34
2 |
Manganese atom increases the amount of USP34.
1 |
Manganese atom increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Manganese atom decreases the amount of USP34.
1 |
Manganese atom decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Magnetite nanoparticle decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
26378955
ctd
No evidence text available
21641980
Formaldehyde affects USP34
2 |
Formaldehyde increases the amount of USP34.
1 |
Formaldehyde increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
23649840
Formaldehyde decreases the amount of USP34.
1 |
Formaldehyde decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
20655997
Decabromodiphenyl ether decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
23640034
ctd
No evidence text available
31675489
Chlorpyrifos affects USP34
2 |
Chlorpyrifos decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
37019170
ctd
No evidence text available
29156651
Cadmium dichloride increases the amount of USP34.
1 |
Cadmium dichloride increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
35301059
Cadmium dichloride decreases the amount of USP34.
1 |
Cadmium dichloride decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
24982889
Benzo[a]pyrene diol epoxide I decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
20018196
ctd
No evidence text available
19150397
Arsenic atom affects USP34
2 |
Arsenic atom increases the amount of USP34.
1 |
Arsenic atom increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Arsenic atom decreases the amount of USP34.
1 |
Arsenic atom decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39836092
Aflatoxin B1 affects USP34
2 |
Aflatoxin B1 increases the amount of USP34.
1 |
Aflatoxin B1 increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
19770486
Aflatoxin B1 demethylates USP34.
1 |
Aflatoxin B1 demethylates USP34. 1 / 1
1 |
ctd
No evidence text available
27153756
ZRANB1 affects USP34
2 |
ZRANB1 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
35944360
biogrid
No evidence text available
33853758
ZNF785 affects USP34
2 |
ZNF785 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
ZNF764 affects USP34
2 |
ZNF764 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
ZNF669 affects USP34
2 |
ZNF669 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
ZNF550 affects USP34
2 |
ZNF550 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
ZNF214 affects USP34
2 |
ZNF214 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
Vehicle Emissions affects USP34
2 |
Vehicle Emissions increases the amount of USP34.
1 |
Vehicle Emissions increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27809917
Vehicle Emissions demethylates USP34.
1 |
Vehicle Emissions demethylates USP34. 1 / 1
1 |
ctd
No evidence text available
25560391
USP34 affects tpa-1
| 2
Modified USP34 increases the amount of tpa-1. 1 / 1
| 1
reach
"On the other hand, USP34 overexpressing remarkably up-regulated the expression of p-AKT and p-PKC in cells."
30686807
USP34 increases the amount of tpa-1. 1 / 1
| 1
reach
"Subsequently, western blotting assay indicated that USP34 silencing significantly down-regulated the expression of p-AKT and p-PKC in cells."
30686807
USP34 affects thrombin-p38
| 2
USP34 activates thrombin-p38. 2 / 2
| 2
reach
"In contrast, USP34 knockdown diminished basal IL-6 expression and decreased thrombin-induced IL-6 production (Fig. 8B), even though both CYLD and USP34 enhance thrombin-p38 signaling."
37865315
reach
"Currently, I am examining the impact of USP34-mediated modulation of thrombin-p38 signaling on endothelial inflammatory responses."
35554628
reach
"A recent study indicated that within the nucleus, USP34 stabilizes the level of axin and positively modulates the Wingless-type (WNT) signaling pathway [ Lui et al., 2011; Sy et al., 2013 ]."
24911659
reach
"Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC."
31943775
USP34 affects ossification
| 2
USP34 activates ossification. 2 / 2
| 2
reach
"Guo et al. found that USP34 accelerated osteogenic differentiation and bone formation through activation of BMP2 signalling [ 27 ]."
33127578
reach
"Importantly, USP34 modulates osteogenic differentiation and bone formation by regulating BMP2 signaling gradients (Guo et al., 2018)."
32582299
USP34 affects apoptotic process
| 2
USP34 inhibits apoptotic process. 2 / 2
| 2
reach
"Pancreatic cancer cell proliferation and migration are promoted by USP34 overexpression via upregulation of the Akt protein, and pancreatic cancer cell apoptosis induced by an Akt inhibitor is reversed by USP34 overexpression (35)."
37664545
reach
"In addition, the level of USP34 was upregulated in pancreatic cancer, and USP34 promoted the proliferation and migration of pancreatic cancer cells, as well as inhibited cell apoptosis [17]."
40051889
USP34 affects ZRANB1
2 |
ZRANB1 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
35944360
biogrid
No evidence text available
33853758
USP34 affects ZNF785
2 |
ZNF785 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects ZNF764
2 |
ZNF764 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects ZNF669
2 |
ZNF669 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects ZNF550
2 |
ZNF550 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects ZNF214
2 |
ZNF214 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
USP34 affects Vitiligo
| 2
USP34 inhibits Vitiligo. 2 / 2
| 2
reach
"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."
37043976
reach
"It further revealed that USP34 deficiency promoted the development of vitiligo with increased PMEL CD8 + T cell enrichment, which was not affected by KU-55933 administration."
37043976
USP34 affects TIMM8A
| 2
USP34 activates TIMM8A. 2 / 2
| 2
reach
"Functional studies found that knockdown of USP34 inhibited HepG2 and HepG2/DDP cell proliferation and survival."
40051889
reach
"Knockdown of USP34 inhibited HepG2 and HepG2/DDP cell viability and survival."
40051889
USP34 affects SUV39H1
2 |
SUV39H1 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects SUMO2/3
| 2
USP34 leads to the sumoylation of SUMO2/3. 2 / 2
| 2
reach
"As expected, immunoblot analyses showed that disruption of USP34 dramatically reduced SUMO1- but not SUMO2/3-sumoylation in GSCs (Fig. 4a, Supplementary Fig. 3a), which was similar to the effect of Pin1 silencing ."
38167292
reach
"Interestingly, silencing USP34 severely inhibits Pin1-mediated SUMO1- but not SUMO2/3-modified sumoylation in GSCs."
38167292
USP34 affects PNN
| 2
USP34 decreases the amount of PNN.
| 1
USP34 decreases the amount of PNN. 1 / 1
| 1
reach
"Similarly as observed for Dpt, overexpressing USP34 significantly reduced Drs expression at 12 and 24hours after infection with the non pathogenic Gram positive bacteria Micrococcus luteus."
25027767
USP34 activates PNN.
| 1
USP34 activates PNN. 1 / 1
| 1
reach
"However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1."
25027767
USP34 affects PMEL
| 2
USP34 inhibits PMEL. 2 / 2
| 2
reach
"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."
37043976
reach
"It further revealed that USP34 deficiency promoted the development of vitiligo with increased PMEL CD8 + T cell enrichment, which was not affected by KU-55933 administration."
37043976
USP34 affects Neoplasms
| 2
USP34 activates Neoplasms. 2 / 2
| 2
reach
"Collectively, these data demonstrate that USP34 promotes GSC maintenance and GBM tumor growth."
38167292
reach
"USP34 is preferentially expressed in GSCs to promote GSC maintenance and GBM tumor growth."
38167292
USP34 affects LYPD4
2 |
LYPD4 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects IL6
| 2
USP34 increases the amount of IL6. 2 / 2
| 2
reach
"In contrast, USP34 knockdown diminished basal IL-6 expression and decreased thrombin-induced IL-6 production (Fig. 8B), even though both CYLD and USP34 enhance thrombin-p38 signaling."
37865315
reach
"CYLD attenuates thrombin-p38–dependent stimulated barrier function and IL-6 production, whereas USP34 promotes IL-6 mRNA expression but does not alter endothelial barrier maintenance (Fig. 9)."
37865315
USP34 affects F2R
| 2
USP34 ubiquitinates F2R.
| 1
USP34 leads to the ubiquitination of F2R. 1 / 1
| 1
reach
"Currently, it is not known whether CYLD and/or USP34 directly modulates ubiquitination of the GPCR PAR1 and/or other p38 pathway components such as p38, TAB1, TAB2, NEDD4-2, and c-Src to control noncanonical p38 MAPK signaling."
37865315
USP34 inhibits F2R.
| 1
USP34 inhibits F2R. 1 / 1
| 1
reach
"Rather, we report that loss of USP34 expression increased mRNA transcript expression of the PAR1-encoding gene, F2R ."
39705380
USP34 affects ERMAP
2 |
ERMAP binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects EPHA1
2 |
EPHA1 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP34 affects CDH1
| 2
USP34 increases the amount of CDH1.
| 1
USP34 increases the amount of CDH1. 1 / 1
| 1
reach
"We observed that inhibition of USP34 caused the loss of E-cadherin from cell-cell contacts, an effect mirrored by TGF-β challenge."
28499884
USP34 decreases the amount of CDH1.
| 1
USP34 decreases the amount of CDH1. 1 / 1
| 1
reach
"Based on these observations, we postulated that USP34 may be involved in the regulation of EMT in mammary gland epithelial cell development.Knockdown of USP34 was found to reduce Axin 1 and E-cadherin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28499884
USP34 affects AXIN2
1 1 |
USP34 deubiquitinates AXIN2. 1 / 1
1 |
ubibrowser
No evidence text available
USP34 deubiquitinates AXIN2 on lysine. 1 / 1
1 |
biopax:reactome
No evidence text available
USP34 affects AKT
| 2
Modified USP34 increases the amount of phosphorylated AKT. 1 / 1
| 1
reach
"On the other hand, USP34 overexpressing remarkably up-regulated the expression of p-AKT and p-PKC in cells."
30686807
USP34 increases the amount of phosphorylated AKT. 1 / 1
| 1
reach
"Subsequently, western blotting assay indicated that USP34 silencing significantly down-regulated the expression of p-AKT and p-PKC in cells."
30686807
SUV39H1 affects USP34
2 |
SUV39H1 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
MAX affects USP34
2 |
MAX decreases the amount of USP34. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
LYPD4 affects USP34
2 |
LYPD4 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
LEF1 affects USP34
2 |
LEF1 decreases the amount of USP34. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Histone affects USP34
| 2
Histone increases the amount of USP34. 2 / 2
| 2
reach
"Mechanism research has found that histone lactylation induced increased expression of USP34, which was involved in the progression and regulation of HCC."
40051889
reach
"Mechanistically, lactylation of histones promoted the expression level of USP34 in HepG2/DDP cells."
40051889
ERMAP affects USP34
2 |
ERMAP binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EPHA1 affects USP34
2 |
EPHA1 binds USP34. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
CTNNB1 affects USP34
| 2
CTNNB1 increases the amount of USP34.
| 1
CTNNB1 increases the amount of USP34. 1 / 1
| 1
reach
"However, the authors also suggest that loss of USP34 inhibited beta-catenin mediated transcription indicating that USP34 may function downstream of beta-catenin to regulate nuclear accumulation of AXI[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
CTNNB1 binds USP34.
| 1
USP34 binds CTNNB1. 1 / 1
| 1
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
32140262
3,4-methylenedioxymethamphetamine decreases the amount of USP34. 2 / 2
2 |
ctd
No evidence text available
26251327
ctd
No evidence text available
20188158
Zinc protoporphyrin increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
22839698
Vorinostat affects USP34
1 |
Vorinostat decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27188386
UbpA affects USP34
| 1
USP34 binds ubpA. 1 / 1
| 1
reach
"The interactions between USP34 and Ub-PA result in the burial of 1704 Å 2 of exposed surface area and a relatively closed conformation of the USP34 structure."
35588869
Tunicamycin affects USP34
1 |
Tunicamycin decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
17127020
Tungsten affects USP34
1 |
Tungsten decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
30912803
Triptonide affects USP34
1 |
Triptonide decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
33045310
Topotecan affects USP34
1 |
Topotecan decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
25729387
Thiram affects USP34
1 |
Thiram increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
38568856
Thioacetamide affects USP34
1 |
Thioacetamide decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
34492290
Sunitinib affects USP34
1 |
Sunitinib increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
31533062
Sorafenib affects USP34
1 |
Sorafenib decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39786591
Rotenone affects USP34
1 |
Rotenone decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39786591
Potassium dichromate decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
23608068
Potassium chromate decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
22079256
Pentabrominated diphenyl ether 100 decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
31675489
Paracetamol affects USP34
| 1
Paracetamol inhibits USP34. 1 / 1
| 1
reach
"A mutation of any residue of the putative triad eliminates the hydrolytic activity of USP34 toward the fluorogenic 7-amido-4-methylcoumarin (AMC)-derived Ub ( Supplementary Figure S2 (A))."
35588869
Oxaliplatin affects USP34
1 |
Oxaliplatin decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
25729387
Miconazole affects USP34
1 |
Miconazole decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27462272
Methylmercury chloride decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
26272509
Methyl methanesulfonate increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
23649840
Lipopolysaccharide, E coli O55-B5 decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
24972896
Lead diacetate affects USP34
1 |
Lead diacetate increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
22839698
Jinfukang affects USP34
1 |
Jinfukang decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27392435
Ivermectin affects USP34
1 |
Ivermectin decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
32959892
Indometacin affects USP34
1 |
Indometacin decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
28628672
Indium tin oxide affects USP34
1 |
Indium tin oxide increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39516272
Hsa-miR-485-5p affects USP34
1 |
Hsa-miR-485-5p decreases the amount of USP34. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hsa-miR-23a-3p affects USP34
1 |
Hsa-miR-23a-3p decreases the amount of USP34. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-218-5p affects USP34
1 |
Hsa-miR-218-5p decreases the amount of USP34. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23212916
Hsa-miR-21-5p affects USP34
1 |
Hsa-miR-21-5p decreases the amount of USP34. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18591254
Hsa-miR-19b-3p affects USP34
1 |
Hsa-miR-19b-3p decreases the amount of USP34. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22382630
Hsa-miR-192-5p affects USP34
1 |
Hsa-miR-192-5p decreases the amount of USP34. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-127-5p affects USP34
1 |
Hsa-miR-127-5p decreases the amount of USP34. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hexabrominated diphenyl ether 153 decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
31675489
Etoposide affects USP34
| 1
Etoposide activates USP34. 1 / 1
| 1
reach
"Paralleling the situation with TCR, knocking down USP34 markedly increased NF-kappaB in cells treated with TNFalpha or etoposide."
23590831
Ethanol affects USP34
1 |
Ethanol decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
29018328
Doxorubicin affects USP34
1 |
Doxorubicin decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
29803840
Dorsomorphin affects USP34
1 |
Dorsomorphin decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27188386
Dexamethasone affects USP34
1 |
Dexamethasone decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
28628672
Coumarin affects USP34
1 |
Coumarin dephosphorylates USP34. 1 / 1
1 |
ctd
No evidence text available
35688186
Clozapine affects USP34
1 |
Clozapine increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
34122009
Clobetasol affects USP34
1 |
Clobetasol decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27462272
Cisplatin affects USP34
1 |
Cisplatin decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27594783
Cadmium atom affects USP34
1 |
Cadmium atom increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
35301059
Bisphenol F affects USP34
1 |
Bisphenol F decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
28628672
Bis(2-ethylhexyl) phthalate inhibits USP34. 1 / 1
| 1
eidos
"In the present study , multiplex RT-PCR results showed that USP34 was downregulated by DEHP in OVCAR5 cells , which suggests a diminished ability to repair DNA damage and increase the risk of POF due to reductions in follicle numbers ."
32143396
Aristolochic acid A decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
33212167
Antithrombin affects USP34
| 1
Antithrombin inhibits USP34. 1 / 1
| 1
reach
"Purified reagent assays were also carried out to investigate antithrombin dependent inhibition of factor Xa and factor IIa activity (USP34 NF26) and heparin cofactor II (HCII) dependent inhibition of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27816772
Antirheumatic drug increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
24449571
Abrine affects USP34
1 |
Abrine decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
31054353
ZRANB2 affects USP34
1 |
USP34 binds ZRANB2. 1 / 1
1 |
biogrid
No evidence text available
22939629
ZNRD2 affects USP34
1 |
ZNRD2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
ZNF514 affects USP34
1 |
ZNF514 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
ZNF460 affects USP34
1 |
ZNF460 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
ZNF418 affects USP34
1 |
ZNF418 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
ZNF354C affects USP34
1 |
ZNF354C binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28514442
ZNF211 affects USP34
1 |
ZNF211 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28514442
ZNF10 affects USP34
1 |
ZNF10 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
ZHX2 affects USP34
1 |
ZHX2 decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
ZFYVE19 affects USP34
1 |
USP34 binds ZFYVE19. 1 / 1
1 |
biogrid
No evidence text available
22939629
ZEB1 affects USP34
1 |
ZEB1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37149635
YP_009227205 affects USP34
1 |
YP_009227205 binds USP34. 1 / 1
1 |
virhostnet
No evidence text available
30037810
Wnt affects USP34
| 1
USP34 binds Wnt. 1 / 1
| 1
sparser
"Lasted studies have reported that snoRNAs could directly bind to functional protein to promote tumorigenesis. xref , xref Therefore, we inferred that USP34 or SNORA70B might bind WNT pathway–related protein to activate it."
31943775
WNT pathway–related protein affects USP34
| 1
USP34 binds WNT pathway–related protein. 1 / 1
| 1
reach
"Lasted studies have reported that snoRNAs could directly bind to functional protein to promote tumorigenesis.48, 49 Therefore, we inferred that USP34 or SNORA70B might bind WNT pathway–related protein to activate it.In general, we identified a six‐snoRNA signature as an independent and specific indicator to diagnose and predict prognosis of ccRCC patients, providing a prospective diagnostic and prognostic biomarker and potential therapeutic targets for ccRCC."
31943775
WASHC4 affects USP34
1 |
WASHC4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22863883
Vincristine affects USP34
1 |
Vincristine increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
23649840
VPS4B affects USP34
1 |
USP34 binds VPS4B. 1 / 1
1 |
biogrid
No evidence text available
22939629
VIRMA affects USP34
1 |
VIRMA binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29507755
USP9X affects USP34
1 |
USP34 binds USP9X. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34-shRNA1 affects USP34
| 1
USP34-shRNA1 decreases the amount of USP34. 1 / 1
| 1
reach
"According to the result of qRT-PCR and western blotting, USP34-shRNA1 significantly downregulated USP34 gene level in PANC-1 cell."
30686807
USP34 affects ubpA
| 1
USP34 binds ubpA. 1 / 1
| 1
reach
"The interactions between USP34 and Ub-PA result in the burial of 1704 Å 2 of exposed surface area and a relatively closed conformation of the USP34 structure."
35588869
USP34 affects titanium
| 1
USP34 activates titanium. 1 / 1
| 1
reach
"Taken together, our data demonstrate that specific deletion of Usp34 in mesenchymal stem cells impairs fixation of titanium implants in mice."
32363724
USP34 affects thiol
| 1
USP34 activates thiol. 1 / 1
| 1
reach
"Peter et al draw attention to the variety of phenotypic features of patients with a microdeletion within 2p15p16.1, which result from the type of gene or genes that have been deleted.14USP34 is a gene which encodes ubiquitin-specific peptidase 34 which enables cysteine-type endopeptidase activity and thiol-dependent deubiquitinase."
39050773
USP34 affects stemness
| 1
USP34 inhibits stemness. 1 / 1
| 1
eidos
"Inhibition of USP34 induces EMT and stemness in mammary epithelial cells [ 63 ] ."
31133011
USP34 inhibits response to xenobiotic stimulus. 1 / 1
| 1
reach
"27 The deletion of USP34 inhibited the survival of laryngeal squamous cell carcinoma cells and reduced the drug resistance of cisplatin in these cells."
35588869
USP34 affects polyubiquitination SOX2
| 1
USP34 inhibits polyubiquitination SOX2. 1 / 1
| 1
eidos
"Moreover , USP34 , as a deubiquitinase , could interact with SOX2 , and reduce the polyubiquitination of SOX2 ."
32783291
USP34 affects p38
| 1
USP34 leads to the dephosphorylation of p38. 1 / 1
| 1
reach
"Depletion of CYLD or USP34 with multiple individual siRNAs significantly increased thrombin-induced p38 phosphorylation but not ERK1/2 phosphorylation."
37865315
USP34 affects osteogenic differentiation
| 1
USP34 activates osteogenic differentiation. 1 / 1
| 1
eidos
"A study has shown that USP34 promotes osteogenic differentiation by activating Smad1 / 5/8 and stabilizing the transcription factor RUNX2 ( Guo et al ., 2020 ) ."
36340031
USP34 inhibits osteoclast differentiation. 1 / 1
| 1
reach
"In addition, another member of the USP family, USP34, inhibits osteoclast differentiation by deubiquitinating the activity of IκBα, a key inhibitor of the NF-κB signaling pathway [32]."
37333461
USP34 affects more resistance drug treatment
| 1
USP34 activates more resistance drug treatment. 1 / 1
| 1
eidos
"USP34 inhibits EMT and cancer stemness and may therefore induce more resistance to the drug treatment [ 102 ] ."
31133011
reach
"Clearly, additional studies are needed to interrogate the mechanisms by which CYLD and USP34 differentially modulate thrombin-induced endothelial barrier disruption and IL-6 production."
37865315
USP34 affects drug sensitivity cisplatin resistant cells
| 1
USP34 inhibits drug sensitivity cisplatin resistant cells. 1 / 1
| 1
eidos
"Finally , we also found that USP34 and SOX2 were upregulated in cisplatin-resistant LSCC cells , but knockdown of USP34 could enhance the drug sensitivity of cisplatin in the resistant cells ."
32783291
USP34 affects disulfur
| 1
USP34 inhibits disulfur. 1 / 1
| 1
reach
"USP34 inhibits the Toll pathway in S2 cells."
25027767
USP34 affects deubiquitination remains uncharacterized
| 1
USP34 activates deubiquitination remains uncharacterized. 1 / 1
| 1
eidos
"Despite its functional importance , how USP34 recognizes ubiquitin and catalyzes deubiquitination remains structurally uncharacterized ."
35588869
USP34 affects dental mesenchymal cells undergo odontogenic differentiation deubiquitination
| 1
USP34 activates dental mesenchymal cells undergo odontogenic differentiation deubiquitination. 1 / 1
| 1
eidos
"Conclusion In summary , we showed that USP34 regulates root morphogenesis and promotes dental mesenchymal cells to undergo odontogenic differentiation through deubiquitination and stabilizes NFIC ."
33686052
USP34 affects chloroform
| 1
USP34 activates chloroform. 1 / 1
| 1
reach
"The high expression of the USP34 can activate the Th2 and Tcm immune cells and recognize tumor cells through cellular and humoral immune effector mechanisms, thereby delaying the recurrence of PCa and improving prognosis."
36811009
USP34 affects cell growth
| 1
USP34 activates cell growth. 1 / 1
| 1
reach
"In addition, knockdown of USP34 could significantly inhibit LSCC cell growth, but overexpression of SOX2 could reverse this effect."
32783291
USP34 affects bone regeneration
| 1
reach
"USP34 knockout leads to low bone mass, increased osteoclasts, and impaired bone regeneration."
35588869
USP34 affects ZRANB2
1 |
USP34 binds ZRANB2. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects ZNRD2
1 |
ZNRD2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects ZNF514
1 |
ZNF514 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects ZNF460
1 |
ZNF460 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects ZNF418
1 |
ZNF418 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects ZNF354C
1 |
ZNF354C binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP34 affects ZNF211
1 |
ZNF211 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP34 affects ZNF10
1 |
ZNF10 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects ZFYVE19
1 |
USP34 binds ZFYVE19. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects ZEB1
1 |
ZEB1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37149635
USP34 affects YP_009227205
1 |
YP_009227205 binds USP34. 1 / 1
1 |
virhostnet
No evidence text available
30037810
reach
"The USP34 is an activator of the WNT signaling pathway ( Piccione et al., 2012 ; Fannemel et al., 2014 )."
29864511
USP34 affects Wnt beta-catenin signaling
| 1
USP34 activates Wnt beta-catenin signaling. 1 / 1
| 1
eidos
"USP34 has been shown to promote Wnt / beta-catenin signaling , which has an important role in several human cancers ( Lui et al ., 2011 ) ."
31410080
USP34 affects Wingless-type (WNT)
| 1
USP34 activates Wingless-type (WNT). 1 / 1
| 1
reach
"A recent study indicated that within the nucleus, USP34 stabilizes the level of axin and positively modulates the Wingless-type (WNT) signaling pathway [ Lui et al., 2011; Sy et al., 2013 ]."
24911659
USP34 affects WNT pathway–related protein
| 1
USP34 binds WNT pathway–related protein. 1 / 1
| 1
reach
"Lasted studies have reported that snoRNAs could directly bind to functional protein to promote tumorigenesis.48, 49 Therefore, we inferred that USP34 or SNORA70B might bind WNT pathway–related protein to activate it.In general, we identified a six‐snoRNA signature as an independent and specific indicator to diagnose and predict prognosis of ccRCC patients, providing a prospective diagnostic and prognostic biomarker and potential therapeutic targets for ccRCC."
31943775
USP34 affects WASHC4
1 |
WASHC4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP34 affects VPS4B
1 |
USP34 binds VPS4B. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects VIRMA
1 |
VIRMA binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29507755
USP34 affects USP9X
1 |
USP34 binds USP9X. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UPP1
1 |
UPP1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects UNK
1 |
USP34 binds UNK. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UFM1
1 |
USP34 binds UFM1. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UFC1
1 |
USP34 binds UFC1. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UCHL3
1 |
USP34 binds UCHL3. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBXN7
1 |
USP34 binds UBXN7. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBXN6
1 |
UBXN6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects UBXN1
1 |
USP34 binds UBXN1. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBQLN4
1 |
USP34 binds UBQLN4. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBQLN2
1 |
USP34 binds UBQLN2. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBQLN1
1 |
USP34 binds UBQLN1. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBL7
1 |
UBL7 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBE4B
1 |
UBE4B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBE2V2
1 |
UBE2V2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBE2V1
1 |
UBE2V1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBE2L3
1 |
UBE2L3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBE2D1
1 |
UBE2D1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBE2C
1 |
UBE2C binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects UBA2
1 |
UBA2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects Toll
| 1
USP34 inhibits Toll. 1 / 1
| 1
reach
"Moreover, USP34 is also necessary to prevent constitutive activation of the Toll pathway."
25027767
USP34 affects TTLL12
1 |
TTLL12 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects TSPYL6
1 |
TSPYL6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP34 affects TSPAN8
1 |
TSPAN8 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects TRIM67
1 |
TRIM67 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36215168
USP34 affects TRIM35
1 |
TRIM35 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects TRIM25
1 |
TRIM25 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29117863
USP34 affects TP53BP1
1 |
TP53BP1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29656893
USP34 affects TP53
1 |
TP53 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
38580884
USP34 affects TOP3B
1 |
TOP3B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35748872
USP34 affects TNFSF13B
1 |
TNFSF13B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
30833792
USP34 affects TNFSF11
| 1
USP34 inhibits TNFSF11. 1 / 1
| 1
reach
"USP34 deficiency leads to RANKL-mediated NF-κB activation and increased osteoclast production, which in turn leads to a phenotype of bone loss in mice."
38940355
USP34 affects TIPARP
1 |
TIPARP binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35439318
USP34 affects TH2
| 1
USP34 activates TH2. 1 / 1
| 1
reach
"The high expression of the USP34 can activate the Th2 and Tcm immune cells and recognize tumor cells through cellular and humoral immune effector mechanisms, thereby delaying the recurrence of PCa and improving prognosis."
36811009
USP34 affects TGOLN2
1 |
TGOLN2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35696571
USP34 affects TCR
| 1
USP34 inhibits TCR. 1 / 1
| 1
reach
"Another deubiquitinase, USP34, has been shown to inhibit TCR and CD28 stimulated NF-kappaB activation in the Jurkat T-cell line."
26260210
USP34 affects TAGLN
1 |
TAGLN binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37149635
USP34 affects SULT1A1
1 |
SULT1A1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects STAM
1 |
STAM binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects SRXN1
1 |
SRXN1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects SRP9
1 |
SRP9 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35271311
USP34 affects SPDL1
1 |
SPDL1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
30258100
USP34 affects SPATA46
1 |
SPATA46 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects SP7
| 1
USP34 activates SP7. 1 / 1
| 1
eidos
"Depletion of USP34 in DPCs also led to decreased expression of SP7 and DSPP , the downstream targets of NFIC ( Fig. 3d ) ."
33686052
USP34 affects SOHLH1
1 |
SOHLH1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects SNRNP200
1 |
biogrid
No evidence text available
22863883
USP34 affects SMAD1
| 1
USP34 activates SMAD1. 1 / 1
| 1
eidos
"USP34 can activate Smad1 / 5/8 to enhance BMP signaling ."
36340031
USP34 affects SLURP1
| 1
USP34 inhibits SLURP1. 1 / 1
| 1
reach
"Depeletion of USP34 inhibited the ALP activity and ARS staining."
33686052
USP34 affects SLPI
| 1
USP34 inhibits SLPI. 1 / 1
| 1
reach
"Depeletion of USP34 inhibited the ALP activity and ARS staining."
33686052
USP34 affects SIRT7
1 |
SIRT7 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22586326
USP34 affects SH2D3C
1 |
SH2D3C binds USP34. 1 / 1
1 |
biogrid
No evidence text available
31980649
USP34 affects SEC24A
1 |
SEC24A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 inhibits Radiation, Ionizing. 1 / 1
| 1
reach
"Another DUB, USP7, has also been shown to deubiquitinate and stabilize RNF168 [XREF_BIBR]; however, RNF168 is itself polyubiquitinated and destabilized upon IR treatment, which is reversed by USP34, suggesting that USP34 specifically stabilizes RNF168 when DNA becomes damaged [XREF_BIBR]."
30831436
USP34 affects RPP21
1 |
RPP21 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects RPA4
1 |
RPA4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
USP34 affects RPA3
1 |
RPA3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
USP34 affects RPA2
1 |
RPA2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
USP34 affects RPA1
1 |
RPA1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
USP34 affects RNF8
| 1
RNF8 binds USP34. 1 / 1
| 1
sparser
"As USP34 interacted with RNF168, but not RNF8 ( xref C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."
23863847
USP34 affects RNF4
1 |
RNF4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29180619
USP34 affects RIGI
1 |
RIGI binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32513696
USP34 affects RECQL4
1 |
RECQL4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29229926
USP34 affects RCOR1
1 |
RCOR1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34709266
USP34 affects RBM3
1 |
RBM3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26472337
USP34 affects Pdfr
| 1
USP34 binds Pdfr. 1 / 1
| 1
sparser
"USP34 gene polymorphisms (rs17008097 and rs17008940) may not be associated with PCOS in the Han Chinese women."
25975428
USP34 affects PUDP
1 |
PUDP binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects PRR11
| 1
USP34 inhibits PRR11. 1 / 1
| 1
reach
"Via inhibiting the PRR11, USP34 could promote the proliferation and migration in PANC-1 cells 54."
37351165
USP34 affects PPARD
1 |
PPARD binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects POU5F1
1 |
POU5F1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP34 affects PML
1 |
PML binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36880596
USP34 affects PLEKHG7
1 |
PLEKHG7 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects PLEKHA4
1 |
PLEKHA4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
31091453
USP34 affects PHF21A
1 |
PHF21A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34709266
USP34 affects PGP
| 1
USP34 inhibits PGP. 1 / 1
| 1
reach
"As expected, interference with USP34 significantly inhibited the protein levels of resistance-related proteins MRP1 and p-gp (Fig. 3e)."
40051889
USP34 affects PCGF1
1 |
PCGF1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP34 affects OCIAD1
1 |
OCIAD1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects NUP43
1 |
NUP43 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37689310
USP34 affects NUP35
1 |
NUP35 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32344865
USP34 affects NFKBIA
| 1
USP34 activates NFKBIA. 1 / 1
| 1
reach
"USP34 knockdown in Jurkat cells promotes mitogen stimulated IkappaBalpha degradation without enhancing IKK activation, suggesting that this deubiquitinase may modulate the proteolytic process involved in IkappaBalpha degradation."
26260210
USP34 affects NFIX
1 |
NFIX binds USP34. 1 / 1
1 |
biogrid
No evidence text available
39617063
USP34 affects NFIB
1 |
NFIB binds USP34. 1 / 1
1 |
biogrid
No evidence text available
39617063
USP34 affects NFIA
1 |
NFIA binds USP34. 1 / 1
1 |
biogrid
No evidence text available
39617063
USP34 affects NANOG
1 |
NANOG binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP34 affects MYC
1 |
MYC binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32140074
USP34 affects MTNR1B
1 |
MTNR1B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26514267
USP34 affects MTNR1A
1 |
MTNR1A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26514267
USP34 affects MSH3
| 1
USP34 inhibits MSH3. 1 / 1
| 1
reach
"As expected, interference with USP34 significantly inhibited the protein levels of resistance-related proteins MRP1 and p-gp (Fig. 3e)."
40051889
USP34 affects MESP2
1 |
MESP2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects MAPK3
1 |
MAPK3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36736316
USP34 affects MAPK1
1 |
MAPK1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36736316
USP34 affects M
1 |
USP34 binds M. 1 / 1
1 |
virhostnet
No evidence text available
26789921
USP34 affects LSCC cell growth
| 1
USP34 activates LSCC cell growth. 1 / 1
| 1
eidos
"In addition , knockdown of USP34 could significantly inhibit LSCC cell growth , but overexpression of SOX2 could reverse this effect ."
32783291
USP34 affects LRRTM4
1 |
LRRTM4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects LOXL4
1 |
LOXL4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects LINC02694
1 |
biogrid
No evidence text available
33961781
USP34 affects LAGE3
1 |
LAGE3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects KDM1A
1 |
KDM1A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34709266
USP34 affects Imd
| 1
USP34 inhibits Imd. 1 / 1
| 1
reach
"We report here that USP2 and USP34 and Puf, in addition to the previously described USP36 and Scny, prevent inappropriate activation of Imd dependent immune signal in unchallenged conditions."
25027767
USP34 affects INF2
1 |
INF2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects IL12
| 1
USP34 inhibits IL12. 1 / 1
| 1
reach
"USP34 deficiency or KU-55933 administration promoted the induction of Ccl2, Ccl5, Il12α, and p-IKKα/β in LPS or CpG stimulated BMDMs; KU-55933 administration could not affect the expression of the above molecules in USP34 deficient BMDMs."
37043976
USP34 affects HUWE1
1 |
HUWE1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37167062
USP34 affects HSPB8
1 |
HSPB8 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects HSP90B1
| 1
HSP90B1 binds USP34 and HMGN2. 1 / 1
| 1
sparser
"The expressions of HSP90B1, USP34 and HMGN2 were significantly negatively associated with tumour grade (p<0.001)."
22363530
USP34 affects HOXB1
1 |
HOXB1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects HMGN2
| 1
HSP90B1 binds USP34 and HMGN2. 1 / 1
| 1
sparser
"The expressions of HSP90B1, USP34 and HMGN2 were significantly negatively associated with tumour grade (p<0.001)."
22363530
USP34 affects HERC5
1 |
HERC5 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34147029
USP34 affects HAPSTR1
1 |
HAPSTR1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37167062
USP34 affects H4atta
| 1
USP34 activates H4atta. 1 / 1
| 1
reach
"However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1."
25027767
USP34 affects H1-6
1 |
H1-6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
24981860
USP34 affects GPCR
| 1
USP34 leads to the ubiquitination of GPCR. 1 / 1
| 1
reach
"Currently, it is not known whether CYLD and/or USP34 directly modulates ubiquitination of the GPCR PAR1 and/or other p38 pathway components such as p38, TAB1, TAB2, NEDD4-2, and c-Src to control noncanonical p38 MAPK signaling."
37865315
USP34 affects GLUL
1 |
GLUL binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35271311
USP34 affects GAB2
1 |
GAB2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects FZR1
1 |
FZR1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33306668
USP34 affects FTCD
1 |
FTCD binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35914814
USP34 affects FOXD4L6
1 |
FOXD4L6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects FGF14
1 |
FGF14 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects FAM83F
1 |
FAM83F binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects F2
| 1
USP34 inhibits F2. 1 / 1
| 1
reach
"Whereas USP34 knockdown enhanced thrombin-promoted p38 signaling and reduced IL-6 cytokine expression but did not alter endothelial barrier integrity."
37865315
USP34 affects ERK
| 1
USP34 leads to the phosphorylation of ERK. 1 / 1
| 1
reach
"Depletion of CYLD or USP34 with multiple individual siRNAs significantly increased thrombin-induced p38 phosphorylation but not ERK1/2 phosphorylation."
37865315
USP34 affects ENTPD1
1 |
ENTPD1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects EMT cancer stemness
| 1
USP34 inhibits EMT cancer stemness. 1 / 1
| 1
eidos
"USP34 inhibits EMT and cancer stemness and may therefore induce more resistance to the drug treatment [ 102 ] ."
31133011
USP34 affects ELP2
1 |
ELP2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP34 affects EGLN3
1 |
EGLN3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26972000
USP34 affects EGFR
1 |
EGFR binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28065597
USP34 affects EEF1AKMT3
1 |
EEF1AKMT3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects E3_Ub_ligase
| 1
reach
"In line with our observation, a previous study showed that USP34 binds and stabilizes RNF168, an E3 required for DNA DSB-associated ubiquitylation [ 25 ]."
30585151
USP34 affects Deubiquitinase
| 1
USP34 binds Deubiquitinase. 1 / 1
| 1
isi
"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."
32783291
USP34 affects DYRK1A
1 |
DYRK1A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35914814
USP34 affects DVL
| 1
USP34 binds DVL. 1 / 1
| 1
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
32140262
USP34 affects DUSP15
1 |
DUSP15 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28675297
USP34 affects DTX2
1 |
DTX2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35198878
USP34 affects DPPA4
1 |
DPPA4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
USP34 affects DNAJB8
1 |
DNAJB8 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects DNAJB2
1 |
DNAJB2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
sparser
"However, the authors also suggest that loss of USP34 inhibited β-catenin mediated transcription indicating that USP34 may function downstream of β-catenin to regulate nuclear accumulation of AXIN ."
28923280
USP34 affects DNA repair
| 1
USP34 activates DNA repair. 1 / 1
| 1
reach
"Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster."
35393473
USP34 affects DNA Damage
| 1
USP34 activates DNA Damage. 1 / 1
| 1
reach
"USP34 promotes cellular responses to DNA damage."
23863847
USP34 affects DCAF4
1 |
DCAF4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37689310
USP34 inhibits Carcinoma, Squamous Cell. 1 / 1
| 1
reach
"27 The deletion of USP34 inhibited the survival of laryngeal squamous cell carcinoma cells and reduced the drug resistance of cisplatin in these cells."
35588869
USP34 affects Carcinogenesis
| 1
USP34 activates Carcinogenesis. 1 / 1
| 1
reach
"Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC."
31943775
USP34 affects CYBB
1 |
CYBB binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects CUL4A
1 |
CUL4A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
30945288
USP34 affects CUL3
1 |
CUL3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35563538
USP34 affects CTAG1B
1 |
CTAG1B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects CFTR
| 1
USP34 deubiquitinates CFTR. 1 / 1
| 1
reach
"For example, in this and a previous study we observed that neither USP34, nor USP8 deubiquitinate CFTR, and only USP10 activity was inhibited by Cif XREF_BIBR, XREF_BIBR."
21455491
USP34 affects CD2AP
1 |
CD2AP binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP34 affects CD28
| 1
USP34 inhibits CD28. 1 / 1
| 1
reach
"Another deubiquitinase, USP34, has been shown to inhibit TCR and CD28 stimulated NF-kappaB activation in the Jurkat T-cell line."
26260210
USP34 affects CCT6A
1 |
CCT6A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34535262
USP34 affects CCL5
| 1
USP34 inhibits CCL5. 1 / 1
| 1
reach
"USP34 deficiency or KU-55933 administration promoted the induction of Ccl2, Ccl5, Il12α, and p-IKKα/β in LPS or CpG stimulated BMDMs; KU-55933 administration could not affect the expression of the above molecules in USP34 deficient BMDMs."
37043976
USP34 affects CCL2
| 1
USP34 inhibits CCL2. 1 / 1
| 1
reach
"USP34 deficiency or KU-55933 administration promoted the induction of Ccl2, Ccl5, Il12α, and p-IKKα/β in LPS or CpG stimulated BMDMs; KU-55933 administration could not affect the expression of the above molecules in USP34 deficient BMDMs."
37043976
USP34 affects C9orf163
1 |
biogrid
No evidence text available
33961781
USP34 affects C11orf71
1 |
biogrid
No evidence text available
33961781
USP34 affects BomS1
| 1
USP34 activates BomS1. 1 / 1
| 1
reach
"However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1."
25027767
USP34 affects BTNL9
1 |
BTNL9 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects BRD4
1 |
BRD4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32416067
USP34 affects BRD1
1 |
BRD1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
31753913
USP34 affects BNIP5
1 |
BNIP5 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects BCL2L12
1 |
BCL2L12 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects B4GALT2
1 |
B4GALT2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects ATP6V1B2
1 |
USP34 binds ATP6V1B2. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects ARL8B
1 |
ARL8B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35844135
USP34 affects ARL4D
1 |
ARL4D binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35844135
USP34 affects ARL11
1 |
ARL11 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35844135
USP34 affects AR
1 |
AR binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35785414
USP34 affects AHCYL1
1 |
AHCYL1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP34 affects AGO4
1 |
AGO4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP34 affects 9c
1 |
9c binds USP34. 1 / 1
1 |
biogrid
No evidence text available
| DOI
USP34 affects 293T
| 1
USP34 binds NFIC and 293T. 1 / 1
| 1
reach
"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."
33686052
UPP1 affects USP34
1 |
UPP1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
UNK affects USP34
1 |
USP34 binds UNK. 1 / 1
1 |
biogrid
No evidence text available
22939629
UFM1 affects USP34
1 |
USP34 binds UFM1. 1 / 1
1 |
biogrid
No evidence text available
22939629
UFC1 affects USP34
1 |
USP34 binds UFC1. 1 / 1
1 |
biogrid
No evidence text available
22939629
UCHL3 affects USP34
1 |
USP34 binds UCHL3. 1 / 1
1 |
biogrid
No evidence text available
22939629
UCHL1 affects USP34
| 1
UCHL1 activates USP34. 1 / 1
| 1
reach
"The RANKL-UCHL1-sCD13 negative feedback loop fine-tunes osteoclastogenesis, and UCHL1 deficiency in osteoclast precursor cells disrupts this feedback loop, promoting osteoclast formation.Deubiquitinating enzymes, extensively studied in the field of bone biology, include OTUB1 , USP26 , USP34 , USP1 , and Cyld ."
39389988
UBXN7 affects USP34
1 |
USP34 binds UBXN7. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBXN6 affects USP34
1 |
UBXN6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
UBXN1 affects USP34
1 |
USP34 binds UBXN1. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBQLN4 affects USP34
1 |
USP34 binds UBQLN4. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBQLN2 affects USP34
1 |
USP34 binds UBQLN2. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBQLN1 affects USP34
1 |
USP34 binds UBQLN1. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBL7 affects USP34
1 |
UBL7 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBE4B affects USP34
1 |
UBE4B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBE2V2 affects USP34
1 |
UBE2V2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBE2V1 affects USP34
1 |
UBE2V1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBE2L3 affects USP34
1 |
UBE2L3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBE2D1 affects USP34
1 |
UBE2D1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBE2C affects USP34
1 |
UBE2C binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBA2 affects USP34
1 |
UBA2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
TTLL12 affects USP34
1 |
TTLL12 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
TSPYL6 affects USP34
1 |
TSPYL6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28514442
TSPAN8 affects USP34
1 |
TSPAN8 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
TRIM67 affects USP34
1 |
TRIM67 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36215168
TRIM35 affects USP34
1 |
TRIM35 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
TRIM25 affects USP34
1 |
TRIM25 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29117863
TP53BP1 affects USP34
1 |
TP53BP1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29656893
TP53 affects USP34
1 |
TP53 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
38580884
TOP3B affects USP34
1 |
TOP3B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35748872
TNFSF13B affects USP34
1 |
TNFSF13B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
30833792
TIPARP affects USP34
1 |
TIPARP binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35439318
TGOLN2 affects USP34
1 |
TGOLN2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35696571
TCR affects USP34
| 1
TCR activates USP34. 1 / 1
| 1
reach
"Consistent with the primary screening, NF-kappaB reporter activity was similarly boosted upon TCR stimulation in USP34- and CYLD silenced Jurkat when compared to control non targeting siRNA transfected cells."
23590831
TCF4 affects USP34
1 |
TCF4 decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
TAGLN affects USP34
1 |
TAGLN binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37149635
SULT1A1 affects USP34
1 |
SULT1A1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
STAM affects USP34
1 |
STAM binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
SRXN1 affects USP34
1 |
SRXN1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
SRP9 affects USP34
1 |
SRP9 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35271311
SPDL1 affects USP34
1 |
SPDL1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
30258100
SPATA46 affects USP34
1 |
SPATA46 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
SOHLH1 affects USP34
1 |
SOHLH1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
SNRNP200 affects USP34
1 |
biogrid
No evidence text available
22863883
SMURF1 affects USP34
| 1
SMURF1 activates USP34. 1 / 1
| 1
reach
"Further experiments showed that depletion of Smurf1 rescued the osteogenic potential of Usp34-deficient MSCs [82]."
36077334
SIRT7 affects USP34
1 |
SIRT7 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22586326
SH2D3C affects USP34
1 |
SH2D3C binds USP34. 1 / 1
1 |
biogrid
No evidence text available
31980649
SEC24A affects USP34
1 |
SEC24A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
RPP21 affects USP34
1 |
RPP21 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
RPA4 affects USP34
1 |
RPA4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
RPA3 affects USP34
1 |
RPA3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
RPA2 affects USP34
1 |
RPA2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
RPA1 affects USP34
1 |
RPA1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37827155
RNF8 affects USP34
| 1
RNF8 binds USP34. 1 / 1
| 1
sparser
"As USP34 interacted with RNF168, but not RNF8 ( xref C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."
23863847
RNF4 affects USP34
1 |
RNF4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29180619
RIGI affects USP34
1 |
RIGI binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32513696
RECQL4 affects USP34
1 |
RECQL4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
29229926
RCOR1 affects USP34
1 |
RCOR1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34709266
RBM3 affects USP34
1 |
RBM3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26472337
Phthalic Acids affects USP34
1 |
Phthalic Acids increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
21061450
Pdfr affects USP34
| 1
USP34 binds Pdfr. 1 / 1
| 1
sparser
"USP34 gene polymorphisms (rs17008097 and rs17008940) may not be associated with PCOS in the Han Chinese women."
25975428
PUDP affects USP34
1 |
PUDP binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
PPARD affects USP34
1 |
PPARD binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
POU5F1 affects USP34
1 |
POU5F1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
PML affects USP34
1 |
PML binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36880596
PLEKHG7 affects USP34
1 |
PLEKHG7 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
PLEKHA4 affects USP34
1 |
PLEKHA4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
31091453
PLAGL2 affects USP34
| 1
PLAGL2 increases the amount of USP34. 1 / 1
| 1
reach
"PLAGL2 also activates the expression of USP34 deubiqutinase that in turn stabilizes Snail1 and promotes proliferation and migration of gastric cancer cells [63]."
35563824
PHF21A affects USP34
1 |
PHF21A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34709266
PCGF1 affects USP34
1 |
PCGF1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
OCIAD1 affects USP34
1 |
OCIAD1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
NUP43 affects USP34
1 |
NUP43 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37689310
NUP35 affects USP34
1 |
NUP35 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32344865
NR6A1 affects USP34
1 |
NR6A1 decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
NFkappaB affects USP34
| 1
USP34 binds NFkappaB. 1 / 1
| 1
sparser
"Given that USP34 does not bind to the NF-κB core components (our unpublished results), we favor a model in which USP34 impacts on the activity of a cytosolic co-activator to ensure IκBα fine-tuning [ xref , xref ]."
23590831
NFIX affects USP34
1 |
NFIX binds USP34. 1 / 1
1 |
biogrid
No evidence text available
39617063
NFIC affects 293T
| 1
USP34 binds NFIC and 293T. 1 / 1
| 1
reach
"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."
33686052
NFIB affects USP34
1 |
NFIB binds USP34. 1 / 1
1 |
biogrid
No evidence text available
39617063
NFIA affects USP34
1 |
NFIA binds USP34. 1 / 1
1 |
biogrid
No evidence text available
39617063
NFE2L1 affects USP34
1 |
NFE2L1 decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
NANOG affects USP34
1 |
NANOG binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
MYCN affects USP34
1 |
MYCN decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
MTNR1B affects USP34
1 |
MTNR1B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26514267
MTNR1A affects USP34
1 |
MTNR1A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26514267
MESP2 affects USP34
1 |
MESP2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
MAPK3 affects USP34
1 |
MAPK3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36736316
MAPK1 affects USP34
1 |
MAPK1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
36736316
MAFG affects USP34
1 |
MAFG decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
M affects USP34
1 |
USP34 binds M. 1 / 1
1 |
virhostnet
No evidence text available
26789921
LRRTM4 affects USP34
1 |
LRRTM4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
LOXL4 affects USP34
1 |
LOXL4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
LINC02694 affects USP34
1 |
biogrid
No evidence text available
33961781
LDHB affects USP34
| 1
LDHB increases the amount of USP34. 1 / 1
| 1
reach
"On the contrary, silencing of LDHA and LDHB decreased the mRNA and protein levels of USP34 (Fig. 4e, f), as well as Pan-Kla and H3K18la levels (Fig. 4f)."
40051889
LDHA affects USP34
| 1
LDHA increases the amount of USP34. 1 / 1
| 1
reach
"On the contrary, silencing of LDHA and LDHB decreased the mRNA and protein levels of USP34 (Fig. 4e, f), as well as Pan-Kla and H3K18la levels (Fig. 4f)."
40051889
LAGE3 affects USP34
1 |
LAGE3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
KDM1A affects USP34
1 |
KDM1A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34709266
INF2 affects USP34
1 |
INF2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
HUWE1 affects USP34
1 |
HUWE1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37167062
HSPB8 affects USP34
1 |
HSPB8 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
HSP90B1 affects USP34
| 1
HSP90B1 binds USP34 and HMGN2. 1 / 1
| 1
sparser
"The expressions of HSP90B1, USP34 and HMGN2 were significantly negatively associated with tumour grade (p<0.001)."
22363530
HSF1 affects USP34
1 |
HSF1 decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
HOXB1 affects USP34
1 |
HOXB1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
HMGN2 affects USP34
| 1
HSP90B1 binds USP34 and HMGN2. 1 / 1
| 1
sparser
"The expressions of HSP90B1, USP34 and HMGN2 were significantly negatively associated with tumour grade (p<0.001)."
22363530
HERC5 affects USP34
1 |
HERC5 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34147029
HAPSTR1 affects USP34
1 |
HAPSTR1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37167062
H1-6 affects USP34
1 |
H1-6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
24981860
GLUL affects USP34
1 |
GLUL binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35271311
GAB2 affects USP34
1 |
GAB2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
FZR1 affects USP34
1 |
FZR1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33306668
FTCD affects USP34
1 |
FTCD binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35914814
FOXF2 affects USP34
1 |
FOXF2 decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
FOXD4L6 affects USP34
1 |
FOXD4L6 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
FOXD1 affects USP34
1 |
FOXD1 decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
FGF14 affects USP34
1 |
FGF14 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
FAM83F affects USP34
1 |
FAM83F binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
ENTPD1 affects USP34
1 |
ENTPD1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
ELP2 affects USP34
1 |
ELP2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22863883
EGLN3 affects USP34
1 |
EGLN3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26972000
EGFR affects USP34
1 |
EGFR binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28065597
EEF1AKMT3 affects USP34
1 |
EEF1AKMT3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
E3_Ub_ligase affects USP34
| 1
reach
"In line with our observation, a previous study showed that USP34 binds and stabilizes RNF168, an E3 required for DNA DSB-associated ubiquitylation [ 25 ]."
30585151
Deubiquitinase affects USP34
| 1
USP34 binds Deubiquitinase. 1 / 1
| 1
isi
"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."
32783291
DYRK1A affects USP34
1 |
DYRK1A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35914814
DVL affects USP34
| 1
USP34 binds DVL. 1 / 1
| 1
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
32140262
DUSP15 affects USP34
1 |
DUSP15 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
28675297
DTX2 affects USP34
1 |
DTX2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35198878
DPPA4 affects USP34
1 |
DPPA4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
26687479
DNAJB8 affects USP34
1 |
DNAJB8 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
DNAJB2 affects USP34
1 |
DNAJB2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
DEHP exposure dose-dependent manner affects USP34
| 1
DEHP exposure dose-dependent manner inhibits USP34. 1 / 1
| 1
eidos
"The results showed that the mRNA levels of USP12 , COPS5 , ATXN3L , and USP49 were increased in A2780 cells ( Figure 1 and Figure S1 ) , and that the mRNA level of USP49 was increased and that of USP34 was decreased in OVCAR5 cells ( Figure 2 and Figure S2 ) by DEHP exposure in a dose-dependent manner ."
32143396
DCAF4 affects USP34
1 |
DCAF4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
37689310
CYBB affects USP34
1 |
CYBB binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
CUL4A affects USP34
1 |
CUL4A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
30945288
CUL3 affects USP34
1 |
CUL3 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35563538
CTAG1B affects USP34
1 |
CTAG1B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
CRX affects USP34
1 |
CRX decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
CD2AP affects USP34
1 |
CD2AP binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22863883
CCT6A affects USP34
1 |
CCT6A binds USP34. 1 / 1
1 |
biogrid
No evidence text available
34535262
C9orf163 affects USP34
1 |
biogrid
No evidence text available
33961781
C11orf71 affects USP34
1 |
biogrid
No evidence text available
33961781
BTNL9 affects USP34
1 |
BTNL9 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
BRD4 affects USP34
1 |
BRD4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
32416067
BRD1 affects USP34
1 |
BRD1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
31753913
BPTF affects USP34
1 |
BPTF decreases the amount of USP34. 1 / 1
1 |
biopax:msigdb
No evidence text available
BNIP5 affects USP34
1 |
BNIP5 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
BCL2L12 affects USP34
1 |
BCL2L12 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
BC1 affects USP34
| 1
BC1 activates USP34. 1 / 1
| 1
reach
"Supporting this notion, BL1 deletion abrogated the catalytic activity of USP34 toward Ub-AMC ( Figure 2 (B))."
35588869
B4GALT2 affects USP34
1 |
B4GALT2 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
Air Pollutants, Occupational increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
27809917
AXIN affects USP34
| 1
USP34 binds AXIN. 1 / 1
| 1
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
32140262
ATP6V1B2 affects USP34
1 |
USP34 binds ATP6V1B2. 1 / 1
1 |
biogrid
No evidence text available
22939629
ARL8B affects USP34
1 |
ARL8B binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35844135
ARL4D affects USP34
1 |
ARL4D binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35844135
ARL11 affects USP34
1 |
ARL11 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35844135
AR affects USP34
1 |
AR binds USP34. 1 / 1
1 |
biogrid
No evidence text available
35785414
AHCYL1 affects USP34
1 |
AHCYL1 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
22939629
AGO4 affects USP34
1 |
AGO4 binds USP34. 1 / 1
1 |
biogrid
No evidence text available
33961781
9c affects USP34
1 |
9c binds USP34. 1 / 1
1 |
biogrid
No evidence text available
| DOI
3-isobutyl-1-methyl-7H-xanthine decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
28628672
3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39786591
293T affects USP34
| 1
USP34 binds NFIC and 293T. 1 / 1
| 1
reach
"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."
33686052
2-hydroxypropanoic acid decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
30851411
2,4,6-tribromophenol decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
31675489
2,3,7,8-Tetrachlorodibenzofuran decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
32109520
17beta-estradiol affects USP34
1 |
17beta-estradiol increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
39298647
1,2-dimethylhydrazine decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
22206623
(-)-epigallocatechin 3-gallate decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
22079256
(-)-demecolcine affects USP34
1 |
(-)-demecolcine increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
23649840
3,3',5,5'-tetrabromobisphenol A decreases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
31675489
3,3',4,4',5-pentachlorobiphenyl increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
28973690
2,3',4,4',5-pentachlorobiphenyl increases the amount of USP34. 1 / 1
1 |
ctd
No evidence text available
31388691