IndraLab

Statements

SOX2 binds USP34. 7 / 7
3 | 1 3
reach
"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."
32783291
biogrid
No evidence text available
23667531
sparser
"Moreover, in cisplatin-resistant laryngeal squamous cell carcinoma (LSCC) cells, USP34’s interaction with SOX2, a key CSC- and EMT-related transcription factor, decreases SOX2 polyubiquitination and augments LSCC cell sensitivity to cisplatin [ xref ] (Fig. xref A)."
38702734
sparser
"As shown in Figure xref ,B, the reciprocal Co‐IPs showed that USP34 could interact with SOX2 in LSCC cells."
32783291
biogrid
No evidence text available
32783291
biogrid
No evidence text available
32783291
sparser
"SOX2, a transcription factor, has been found to be one of the promoters for LSCC tumorigenesis and drug resistance. xref And in this study, we found that USP34 could interact with SOX2, and prevent SOX2 from degradation through ubiquitin‐proteasome pathway, which further explained one of the reasons why SOX2 was highly expressed in LSCC."
32783291