IndraLab

Statements

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"PLAGL2 also activates the expression of USP34 deubiqutinase that in turn stabilizes Snail1 and promotes proliferation and migration of gastric cancer cells [63]."
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"Functional studies found that knockdown of USP34 inhibited HepG2 and HepG2/DDP cell proliferation and survival."
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"In addition, the level of USP34 was upregulated in pancreatic cancer, and USP34 promoted the proliferation and migration of pancreatic cancer cells, as well as inhibited cell apoptosis [17]."
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"Pancreatic cancer cell proliferation and migration are promoted by USP34 overexpression via upregulation of the Akt protein, and pancreatic cancer cell apoptosis induced by an Akt inhibitor is reversed by USP34 overexpression (35)."
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"In addition, USP34 overexpression promoted PANC-1 cell proliferation and migration via up-regulating the proteins of p-AKT and p-PKC."
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"USP34 can also promote the proliferation and migration of pancreatic cancer cells by upregulating p-AKT and p-PKC proteins (Gu et al., 2019)."
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