IndraLab

Statements


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"We present evidence that knockdown of Ubiquitin Specific Protease 34 (USP34) selectively enhanced NF-kappaB activation driven by TCR engagement, similarly to siRNA against the well characterized DUB cylindromatosis (CYLD)."

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"Hence, our results suggest that USP34 likely functions downstream of the CBM-IKK nexus to enhance NF-kappaB activation."

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"Combined, these results indicate that USP34 shares some functional similarities with CYLD and selectively targets the NF-kappaB signaling pathway."