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PIN1 binds USP34. 7 / 7
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"The interaction between USP34 and Pin1 in GSCs were validated by co-immunoprecipitation (Fig. 1d)."
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"Given that USP34 interacts with and stabilizes Pin1, we sought to explore the mechanisms regulating the affinity of Pin1 to USP34."
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"These data suggest that Plk1 promotes serine phosphorylation of Pin1 to stabilize Pin1 proteins in GSCs.We then investigated whether Plk1-mediated phosphorylation of Pin1 affected the interaction between Pin1 and USP34."
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"Co-immunoprecipitation analyses showed that inhibition of Plk1 by SBE 13 attenuated the interaction between Pin1 and USP34 (Fig. 2e)."
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"In addition, interfering the binding of Pin1 to USP34 by inhibiting Pin1 phosphorylation with the Plk1 inhibitor SBE 13 downregulated Pin1 expression (Fig. 2c), indicating Plk1 as another target to promote Pin1 degradation."
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"Zhu et al.’s study revealed the interaction between Pin1 and ubiquitin specific peptidase 34 (USP34) in glioma stem cells."
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"Pin1 interacts with USP34, a deubiquitinase with preferential expression and oncogenic function in GSCs."
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