IndraLab

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USP34 increases the amount of PIN1. 5 / 5
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"Disruption of the endogenous USP34 with lentiviral-mediated short hairpin RNAs (shRNAs) resulted in a remarkable reduction of Pin1 protein levels in GSCs, whereas Pin1 mRNA levels did not decrease (Fig. 1g, Supplementary Fig. 1d, e), indicating that USP34 regulated Pin1 expression at the protein level."
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"Disruption of USP34 severely reduced Pin1 protein levels (Fig. 1g), suggesting that USP34 inhibitors, although not available so far, would inhibit Pin1 expression."
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"Additionally, we found that USP34 could increase the expression of PIN1 via SUMOylation in cervical cancer cells."
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"This study confirmed that USP34 could upregulate PIN1 expression and SUMOylation, thereby inhibiting ferroptosis by suppressing the cGAS-STING pathway and in turn promoting the progression of cervical cancer."
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"The above data indicate that USP34 as a Pin1-interacting DUB may positively regulate Pin1 expression in GSCs and GBMs.Next, we investigated whether USP34 had the capacity to deubiquitinate and stabilize Pin1 proteins in GSCs."
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