IndraLab

Statements

ANT1 binds USP34. 7 / 7
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"We then reveal the USP34-ANT1 axis as an upstream regulator of Parkin-dependent mitophagy in osteoarthritic chondrocytes."
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"Additionally, the involvement of ANT1 in cell death regulation might influence the rate of chondrocyte loss. xref , xref Therefore, the protection conferred by the USP34-ANT1 axis may extend beyond quality control to include the preservation of mitochondrial bioenergetics."
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"The USP34-ANT1 axis emerges as both a critical determinant of disease progression and a promising target for therapeutic intervention for TMJ disorders."
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"Our results suggest that enhancing mitophagy via USP34-ANT1 axis may help manage symptoms and improve the life quality of TMJ OA patients, paralleling emerging approaches targeting mitophagy in neurodegenerative diseases. xref , xref These findings identify the regulation of mitochondrial homeostasis by ubiquitin signaling in chondrocytes as a core mechanism maintaining articular cartilage health, thereby refining the conceptual framework for TMJ OA pathogenesis."
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"Co-immunoprecipitation analysis confirmed a direct interaction between USP34 and ANT1 ( xref )."
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"Mechanistically, we define the USP34-ANT1 axis as a component upstream of the PINK1-Parkin pathway."
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"To definitively validate the protective function of the USP34-ANT1 axis, we co-activated both molecules in IL-1β-treated chondrocytes."
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