IndraLab

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DAZAP1 binds USP34. 4 / 4
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"Subsequent RNA immunoprecipitation (RIP) assays confirmed the direct interaction between DAZAP1 and USP34 mRNA (Fig.  xref C)."
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"The precise structural basis of DAZAP1-USP34 mRNA interaction remains to be fully characterized, which would provide deeper insights into the RNA recognition mechanism."
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"Mechanistically, we demonstrate that DAZAP1 binds to and stabilizes USP34 mRNA, promoting USP34 protein expression, which in turn enhances PIN1 protein stability and activates the MAPK signaling pathway, ultimately driving GC progression and chemoresistance."
41331184
sparser
"Mechanistically, DAZAP1 bound and stabilized USP34 mRNA, leading to increased USP34 protein expression, which in turn mediated the deubiquitination and stabilization of the oncoprotein PIN1."
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