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USP34 activates cell differentiation. 4 / 4
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"In addition, osteogenic differentiation was inhibited by USP34 depletion [40] and USP2 was also reported to be associated with osteogenesis [41]."
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"Indeed, USP34-deficient dental pulp cells (DPCs) inhibited odontogenic differentiation with downregulation of nuclear factor I/C (NFIC), and overexpression of NFIC partially restores the impaired odontogenic potential of DPCs, as reported by Jiang et al. (2021)."
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"Importantly, USP34 modulates osteogenic differentiation and bone formation by regulating BMP2 signaling gradients (Guo et al., 2018)."
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"Guo et al. found that USP34 accelerated osteogenic differentiation and bone formation through activation of BMP2 signalling [ 27 ]."
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